Ohio State Neuroscience Centr Core

俄亥俄州立神经科学中心核心

• 批准号: 8374600
• 负责人: KARL H OBRIETAN
• 金额: $ 20.05万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8374600
• 关键词: Animal Model; Aquaculture; Basic Science; Biological Models; Development; Disease; Etiology; Faculty; Funding; Generations; Genetic; Genome; Grant; Knock-in Mouse; Knock-out; Knockout Mice; Modeling; Mus; National Institute of Neurological Disorders and Stroke; Neurobiology; Neurosciences; Ohio; Paper; Phase; Qualifying; Research; Research Personnel; Research Project Grants; Services; Transgenic Mice; Transgenic Mouse Facility; Transgenic Organisms; Zebrafish; cost; innovation; mouse model; nervous system disorder; novel

CORE B: GENETICS CORE The purpose of this Core is to provide support for transgenic mouse and zebrafish research. This Core will facilitate current NINDS-funded research and stimulate synergistic Interactions between diverse Investigators using different animal model systems. This support will benefit all investigators by subsidizing costs and providing advanced genome editing services and aquaculture services. The Genetics Core has two components, each with its own faculty Director. I. Transgenic Mice Core Overview The aim of this Core is to support the development of novel mouse models that will facilitate NINDS-funded researchers and stimulate synergistic interactions between Pis in the OSU Neuroscience Center. Because the Core will subsidize the cost of making transgenic and knockout mice, it will support new investigators to develop mouse models which otherwise could be cost prohibitive. This support will be provided by subsidizing costs of generating transgenic and knockout mouse lines and subsidizing the per diems during the initial expansion and characterization phase of the mouse line. Over the 4.5 years of the grant 43 transgenic mice were generated using Core Support benefiting four Pis (Oberdick, Burghes, Obrietan, Yoon). This Core component was cited in twelve papers and led to two new R01s. The projected need for the renewal is forty two transgenics and ten knock outs benefiting ten Pis. Thus, this is a valued, productive Core.

核心B：遗传学核心 该核心的目的是为转基因小鼠和斑马鱼研究提供支持。该核心将促进当前的NINDS资助研究，并使用不同的动物模型系统刺激不同研究者之间的协同相互作用。这种支持将通过补贴成本并提供高级基因组编辑服务和水产养殖服务来使所有研究人员受益。遗传学核心有两个组成部分，每个组成部分都有自己的教师主任。 I.转基因小鼠核心 概述 该核心的目的是支持新型小鼠模型的发展，这些模型将促进NINDS资助的研究人员并刺激OSU神经科学中心中PI之间的协同相互作用。由于核心将补贴制造转基因和基因敲除小鼠的成本，因此它将支持新的研究人员开发鼠标模型，否则这些模型可能是成本较高的。通过补贴将提供此支持 在小鼠线的初始扩展和表征阶段，生成转基因和敲除小鼠线以及补贴每个Diem的成本。在43年的43年赠款中，使用了受益于四个PI（Oberdick，Burghes，Obrietan，Yoon）的核心支持产生的43只转基因小鼠。该核心组件在十二篇论文中引用，并导致了两个新的R01。预计续订的需求是42 转基因和十幅敲门局受益于十个PI。因此，这是一个有价值的，有效的核心。