Task-free Presurgical Evaluation of Lateral, Eloquent Cortex & Epileptic Foci

外侧口才皮层的无任务术前评估

• 批准号: 8233306
• 负责人: Hesheng Liu
• 金额: $ 17.91万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2016-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8233306
• 关键词: Address; Anatomy; Area; Barbiturates; Brain; Brain Diseases; Brain Mapping; Brain imaging; Cerebral hemisphere; Clinical; Clinical effectiveness; Epilepsy; Evaluation; Event; Excision; Foundations; Foxes; Functional Magnetic Resonance Imaging; Goals; Gold; Handedness; Image; Imaging Techniques; Individual; Language; Language Disorders; Lateral; Lesion; Link; Location; MRI Scans; Magnetic Resonance; Magnetic Resonance Imaging; Magnetoencephalography; Maps; Measurement; Measures; Memory; Methods; Motor; Neurosciences Research; Operating Rooms; Operative Surgical Procedures; Participant; Patient Participation; Patients; Postoperative Period; Procedures; Research; Research Personnel; Research Project Grants; Rest; Risk; Series; System; Techniques; Testing; Time; Tissues; Validity and Reliability; barbituric acid salt; base; career; clinical application; design; improved; indexing; insight; neuroimaging; new technology; novel; novel strategies; programs; public health relevance; tumor

DESCRIPTION (provided by applicant): Pre-surgical evaluation benefits from information about the location of functional brain systems and dysfunctional tissue. Recently, methods based on analysis of spontaneous activity measured by functional MRI have shown promise for identifying brain systems in subjects resting and while asleep. Here we will develop and evaluate a novel method using rest-state intrinsic activity to map multiple systems within the brain including language, memory, and motor systems. Specifically, this project aims to address three critical challenges in pre-surgical mapping. First, this project will seek to develop a new language and memory lateralization technique as a candidate to replace the traditional invasive Wada test. Second, we hypothesize that essential areas of cortex can be mapped using intrinsic functional connectivity linked to specific brain systems. Finally, by assessing the disruption of functional connectivity, we will seek to localize brain lesions and epileptogenic cortex. This project proposes a new approach for pre-surgical mapping for patients with brain lesions and has the potential to significantly improve surgical planning. PUBLIC HEALTH RELEVANCE: This project aims to replace the traditional pre-surgical mapping by providing a means to determine functional laterality, eloquent cortex and epileptic foci simultaneously and with minimal task requirements.

描述（由申请人提供）：手术前评估的益处来自有关功能性脑系统和功能失调组织的位置的信息。最近，基于功能性MRI测量的自发活性的分析的方法显示了识别静止和入睡时脑系统的有望。在这里，我们将使用REST状态固有活动来开发和评估一种新颖的方法，以绘制大脑中的多个系统，包括语言，记忆和运动系统。具体而言，该项目旨在应对手术前映射中的三个关键挑战。首先，该项目将寻求开发一种新的语言和记忆横向技术，以替代传统的侵入性WADA测试的候选人。其次，我们假设可以使用与特定大脑系统相关的固有功能连通性来映射皮层的重要区域。最后，通过评估功能连通性的破坏，我们将寻求定位脑病变和癫痫发作。该项目提出了一种针对患有脑病变患者的手术前映射的新方法，并有可能显着改善手术计划。 公共卫生相关性：该项目旨在通过提供一种手段来确定功能性横向性，雄辩的皮层和癫痫病焦点，并具有最小的任务要求，以取代传统的外科术前映射。