Center for Transdisciplinary ELSI Research in Translational Genomics

ELSI 转化基因组学跨学科研究中心

• 批准号: 8513527
• 负责人: Barbara A. Koenig
• 金额: $ 26.55万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-16 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8513527
• 关键词: Address; Adult; Advisory Committees; Affect; Aging; California; Clinical; Clinical Medicine; Clinical Research; Collaborations; Collection; Communities; Community Outreach; Computerized Medical Record; Conflict (Psychology); DNA; Data; Databases; Development; Discipline; Discipline of Nursing; Disease; Education; Ensure; Environment; Environmental Risk Factor; Epidemiologic Studies; Ethnic Origin; Faculty; Failure; Fellowship; Fellowship Program; Focus Groups; Fostering; Funding; Gender; Gender Role; Genes; Genetic; Genetic Counseling; Genetic Translation; Genome; Genomics; Geographic Information Systems; Goals; Harvest; Health; Health Policy; Health Surveys; Health system; Human Genome; Incidental Findings; Individual; Informed Consent; Integrated Delivery of Health Care; Intervention; Joints; Laws; Learning; Legal; Length; Link; Maps; Measures; Medicine; Modeling; Outcome; Participant; Patients; Pharmacy facility; Pilot Projects; Policies; Policy Analysis; Prevention; Public Health; Race; Research; Research Design; Research Subjects; Research Training; Resources; Sampling; San Francisco; Science Policy; Scientist; Series; Social Policies; Societies; Structure; Students; System; Testing; Training; Translating; Translational Research; Translations; Uncertainty; Underrepresented Minority; Universities; Voice; Woman; Work; base; biobank; clinical application; clinical care; clinically significant; cohort; college; design; doctoral student; ethical legal social implication; genetic epidemiology; genetic variant; genome analysis; genome-wide; health disparity; human subject protection; improved; interdisciplinary collaboration; medical specialties; men; novel; pre-doctoral; programs; public health relevance; research clinical testing; research in practice; sex; social; symposium; telomere; web site; working group

DESCRIPTION (provided by applicant): Harvesting the benefits of genomics requires a new kind of transdisciplinary cooperation. Over the next three years, we will create the Center for Transdisciplinary ELSl Research in Translational Genomics (CT2G) to address key ELSl questions in translational research. The proposed Center brings together the unique resources of Kaiser Permanente Northern California (KPNC), including its Division of Research, and the University of California, San Francisco (UCSF), including the Hastings College of the Law Consortium on Law, Science & Health Policy. A key CT2G resource for training, research, deliberation, and policy analysis is the Kaiser Permanente "Research Program on Genes, Environment, and Health" (RPGEH), designed to foster epidemiological studies. The RPGEH links together participants' data from electronic medical records, biospecimens, health surveys and geographic information systems. The RPGEH includes genome-wide genetic data and measures of telomere length from a sample of over 110,000 men and women, who constitute the Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort. Deepening the existing collaborations between scientists and clinicians at KPNC and UCSF, and utilizing the unique structure of KPNC's integrated health care delivery system, we aim to: 1) Create CT2G and nurture its development as a novel resource for ELSl research in translational genomics. * Implement a management plan and form a Steering Committee and External Advisory Panel * Develop a strong intellectual community through a website, seminar series, and annual conferences * Fund small pilot projects to elucidate barriers to effective genomics translation 2) Convene joint KPNC/UCSF working groups to address critical issues in translational genomics. Focusing on projects with tangible outcomes, we will bring together scholars who have not yet collaborated, creating a blueprint for long-term transdisciplinary work that joins empirical and normative approaches. 3) Plan and initiate a program in ELSl education focused on pre-doctoral students and clinicians. * To expand the pool of under-represented minority ELSl scholars, we will plan and gain approval for a pre-doctoral fellowship program for students from a range of disciplines. * To enhance transdisciplinary collaboration, we will develop a one year ELSl fellowship for clinicians from multiple fields, including nursing, pharmacy, genetic counseling, and clinical medicine.

描述（由申请人提供）：收获基因组学的好处需要一种新型的跨学科合作。在接下来的三年中，我们将创建转化基因组学（CT2G）跨学科ELSL研究中心，以解决转化研究中的关键ELSL问题。拟议的中心汇集了北加州北加州的独特资源（KPNC），包括其研究部以及加利福尼亚大学旧金山大学（UCSF），包括黑斯廷斯法律法律联盟，科学与健康政策。用于培训，研究，审议和政策分析的关键CT2G资源是Kaiser Permanente“基因，环境和健康研究计划”（RPGEH），旨在促进流行病学研究。 RPGEH将参与者的数据链接在一起，来自电子病历，生物测量，健康调查和地理信息系统。 RPGEH包括全基因组遗传数据和端粒长度的测量，这些样本来自110,000多名男女，这些样本构成了成人健康与衰老的遗传流行病学研究（GERA）同类。 加深了KPNC和UCSF科学家与临床医生之间的现有合作，并利用KPNC综合医疗保健提供系统的独特结构，我们的目标是： 1）创建CT2G并培养其发展为ELSL转化基因组学研究的新资源。 *实施管理计划并组成指导委员会和外部咨询小组 *通过网站，研讨会系列和年度会议建立强大的知识分子社区 *资助小型试点项目，以阐明有效基因组学翻译的障碍 2）召集KPNC/UCSF联合工作组解决转化基因组学的关键问题。 为了关注具有切实成果的项目，我们将汇集尚未合作的学者，为长期跨学科工作创造蓝图，加入经验和规范方法。 3）计划并启动一项针对博士前学生和临床医生的ELSL教育计划。 *为了扩大代表性不足的少数民族ELSL学者的库，我们将为来自各个学科的学生计划并获得批准，并获得一项博士前奖学金计划。 *为了增强跨学科合作，我们将为来自多个领域的临床医生建立一年的ELSL奖学金，包括护理，药房，遗传咨询和临床医学。