Human Energy and Body Weight Regulation Core

人体能量和体重调节核心

• 批准号: 8741646
• 负责人: Kong Chen
• 金额: $ 36.98万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8741646
• 关键词: Adipose tissue; Adult; Basal metabolic rate; Biomechanics; Body Composition; Body Temperature; Body Weight; Cannabis Smoking; Cell physiology; Child; Chronic; Clinical; Clinical Nutrition; Clinical Research; Cohort Studies; Collaborations; Cross-Over Studies; Data Analyses; Disease; Dose; Double-Blind Method; Dual-Energy X-Ray Absorptiometry; Energy Intake; Energy Metabolism; European; Exercise stress test; Fasting; Fatigue; Fatty Liver; Food; Gait; Gender; Glucose Intolerance; Heart Rate; Human; Hyperinsulinism; Iceland; Immunity; Inborn Errors of Metabolism; Infection; Inpatients; Insulin; Insulin Resistance; International; Journals; Leptin; Life; Limb structure; Lipodystrophy; Manuscripts; Measurement; Metabolic; Modification; National Heart, Lung, and Blood Institute; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Netherlands; Obesity; Older Population; Outpatients; Overweight; Pancreas; Paper; Patients; Pattern; Phase; Phenotype; Physical activity; Physiology; Placebo Control; Population; Protocols documentation; Randomized; Regulation; Research; Research Design; Research Personnel; Rest; Rewards; Services; Sex Characteristics; Skeletal Muscle; Speed; Surveys; Techniques; United States National Institutes of Health; Visceral; Vitamin E; Walking; Withdrawal; Woman; analytical method; behavior test; chronic liver disease; experience; fitness; instrument; metabolic abnormality assessment; muscle form; non-alcoholic fatty liver; nutrition; programs; respiratory

New protocols started in FY13: 1. 13-DK-0057: Short Term Effects of Leptin Withdrawal or Initiation in Lipodystrophy Independent of Energy Intake. PI Rebecca Brown, MD. ClinicalTrials.gov Identifier: NCT01778556. 2. 13-DK-0136: A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, 2-Period Crossover Study to Evaluate the Effect of RM-493 on Energy Expenditure in Obese Subjects. PI. Monica Skarulis, MD. ClinicalTrials.gov Identifier: NCT01867437. 3. 13-Dk-0013: Impact of Chronic Cold Exposure on Energy Metabolism in Humans. PI, Francesco Celi, MD. ClinicalTrials.gov Identifier: NCT01730105. 4. 13-DK-0002: Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E. PI, Yaron Rotman, MD. ClinicalTrials.gov identifier: NCT01792115. 5. 13-DK-0142: The Physiology of Fatigue in Patients With Chronic Liver Disease. PI, Yaron Rotman, MD. ClinicalTrials.gov identifier: NCT01867385. 6. 13-HG-0053: The NIH Mini Study: Metabolism, Infection and Immunity in Inborn Errors of Metabolism. PI, Peter McGuire, MD. ClinicalTrials.gov Identifier: NCT01780168 Research highlights: 1. Our clinical support services include routine measurements of resting metabolic rate in patients that ranges from young children (12 months) in the Undiagnosed Disease Program (UDP) to severely obese patients. The experiences led to an invited review manuscript (European Journal of Clinical Nutrition) that I coauthored with Dr. Tricia Psato from the Clinical Center Department of Nutrition. We highlighted the advancements, rewards and challenges of the technique, and the precautions and interpretations that are often difficult in such clinical populations. 2. A long-term collaboration with Dr. Richard Cannon (NHLBI) in the Keep-the-Beat II Study led to one manuscript in the International Journal of Obesity, where we found that hyperinsulinemia in overweight or obese women was associated with increased extremity muscle mass, which was partially reversible with reduction in fasting insulin concentration, suggesting the stimulatory effects of insulin on skeletal muscle in the overweight and obese. 3. In a collaboration with researchers at NIDA and NIAAA in a sub-study nested in the protocol Study of the Phenotype of Overweight and Obese Adults (07-DK-0077), we found that, when compared to BMI-matched normal controls, chronic cannabis smoking was associated with visceral adiposity and adipose tissue insulin resistance but not with hepatic steatosis, insulin insensitivity, impaired pancreatic β-cell function, or glucose intolerance. 4. We have been collaborating with investigators inside and outside of the NIH in field research using accelerometers. It continues to result in manuscripts. The Iceland study cohort revealed that there were gender differences in accelerometer-associated physical activity, even after adjusting for the difference in walking speed, which suggests that there were biomechanical differences in gait patterns between genders in the older populations. The other paper, we used the objective accelerometer to validate a subjective physical activity survey in an older population in the Netherlands. Services rendered: energy expenditure by whole-room respiratory chambers (444), resting energy expenditure by metabolic carts (290), graded exercise tests (102), experimental food behavior tests (103), and body composition (274 DXA, 204 Bod Pod), all of which were significantly increased from FY12.

新协议始于13财年： 1。13-DK-0057：瘦素戒断或脂肪营养不良的短期影响与能量摄入无关。 Pi Rebecca Brown，医学博士。临床标识符：NCT01778556。 2。13-DK-0136：1B期，随机，双盲，安慰剂对照，多剂量，2周期跨界研究，以评估RM-493对肥胖受试者能量消耗的影响。 pi。莫妮卡·斯卡卢斯（Monica Skarulis），医学博士。临床标识符：NCT01867437。 3。13-DK-0013：慢性冷暴露对人类能量代谢的影响。 PI，Francesco Celi，医学博士。临床标识符：NCT01730105。 4。13-DK-0002：用不同剂量的维生素E. Pi，Yaron Rotman，MD的非酒精性脂肪肝的治疗。临床标识符：NCT01792115。 5。13-DK-0142：慢性肝病患者疲劳的生理。 PI，Yaron Rotman，医学博士。临床标识符：NCT01867385。 6。13-HG-0053：NIH迷你研究：代谢的新陈代谢，感染和免疫力。 PI，彼得·麦奎尔（Peter McGuire），医学博士。 临床标识符：NCT01780168 研究重点： 1。我们的临床支持服务包括常规测量静息代谢率的常规测量，包括未诊断疾病计划（UDP）到严重肥胖患者的年幼儿童（12个月）。这些经验导致了我与临床中心营养部的Tricia Psato博士合着的邀请的评论手稿（欧洲临床营养杂志）。我们强调了该技术的进步，奖励和挑战，以及在这种临床人群中通常很难的预防措施和解释。 2。与理查德·坎农博士（NHLBI）的长期合作，在国际肥胖杂志上导致了一个手稿，我们发现超重或肥胖女性的高胰岛素血症与肢性肌肉质量的增加相关，这在禁食胰岛素浓度中降低了胰岛素浓度的刺激效果，这是可逆性的，这是可逆的，这是刺激性的效果。 3. In a collaboration with researchers at NIDA and NIAAA in a sub-study nested in the protocol Study of the Phenotype of Overweight and Obese Adults (07-DK-0077), we found that, when compared to BMI-matched normal controls, chronic cannabis smoking was associated with visceral adiposity and adipose tissue insulin resistance but not with hepatic steatosis, insulin insensitivity,受损的胰腺β细胞功能或葡萄糖不耐症。 4。我们一直在使用加速度计与NIH内外的研究人员合作。它继续导致手稿。冰岛研究队列表明，即使调整了步行速度差异，与加速度计相关的体育活动之间存在性别差异，这表明较旧人群的性别之间的步态模式存在生物力学差异。另一篇论文，我们使用客观加速度计在荷兰老年人群中验证主观体育活动调查。 提供的服务：全室呼吸室的能量消耗（444），代谢推车的静息能量消耗（290），分级运动测试（102），实验性食品行为测试（103）和身体组成（274 DXA，204 BOD POD），所有这些都大大增加了FY12的范围。