RACIAL VARIATION IN FOOD ALLERGY: MECHANISMS AND RISK

食物过敏的种族差异：机制和风险

基本信息

批准号：
8044140
负责人：
Christine LM Joseph
金额：
$ 21.9万
依托单位：
HENRY FORD HEALTH SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-15 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8044140
关键词：
2 year old Affect African American Age Age-Months Allergens Allergic Allergy to eggs Allergy to peanuts American Asthma Atopic Dermatitis Behavior Birth Breast Feeding Canis familiaris Caregivers Case-Control Studies Child Childhood Clinical Data Concentration measurement County Data Development Diagnosis Disease Endotoxins Environment Environmental Risk Factor Etiology Exposure to Extrinsic asthma Family history of Felis catus Food Food Hypersensitivity Funding Goals Grant Health House Dust Human Milk Hypersensitivity IgE Immune system Infant Inhalant dose form Interleukin-10 Intervention Interview Knowledge Lead Longitudinal Studies Measures Mediating Medical Milk Milk Hypersensitivity Morbidity - disease rate Mothers National Institute of Allergy and Infectious Disease Outcome Peanuts - dietary Population Population Heterogeneity Population Study Predisposition Prevalence Race Research Risk Risk Factors Sampling Serum Solid Subgroup Supplementation Tobacco smoke Transforming Growth Factor beta Variant atopy base cockroach allergen cohort cytokine disorder risk egg feeding food allergen genetic risk factor high risk modifiable risk population based prevent sex skin prick test therapy development

项目摘要

DESCRIPTION (provided by applicant): Research on risk factors for IgE-mediated food allergy is limited. Given that food allergy is often the first manifestation of atopy, it is not only important to increase our knowledge of food allergy etiology and progression, but to identify risk factors for transient vs. persistent IgE-mediated food allergy, and ultimately use this information to develop interventions to prevent what amounts to an onset of the allergic march. The overall goal of this project is to use an existing birth cohort to explore potential risk factors for milk, egg, or peanut allergy, by age 24 months. Central to this proposal is the risk of food allergy associated with infant feeding practices, including age at introduction of solid or complementary foods and factors related to breastfeeding and duration of breastfeeding. We propose using data from the Wayne County Health, Environment & Atopy Longitudinal Study, or WHEALS birth cohort, established with NIAID funding in 2002. To this data, the proposed study will add (1) a panel of allergists who will make a determination of IgE-mediated food allergy by review of data from interviews with caregivers of infants in the cohort as well as available clinical data, including serum total and specific IgE measured from birth - 2 years and skin prick tests conducted at 2 years; (2) a medical chart review of the infant record, which will also be available to the panel of allergists for determination of IgE-FA; and (3) measurement of concentrations of transforming growth factor beta (TGF¿) and interleukin 10 (IL10) in mature breast milk. These activities are not included under funding of the current WHEALS grant, and neither food allergy nor food sensitization is an outcome for the aims of the previously funded WHEALS grant. Aim 1 of the proposed application is to estimate the prevalence of IgE-mediated food allergy at age 2 years. Aim 2 is to examine the relationship of infant feeding practices to prevalence of food allergy, adjusting for family history of allergy, exposure to tobacco smoke, indoor allergens and endotoxin measured in house dust. An exploratory Aim 3 is to use a case-control study to examine the relationship between prevalence of IgE-mediated food allergy and concentrations of transforming growth factor beta (TGF¿) and interleukin 10 (IL10) in mature breast milk. We will take advantage of the diversity in the WHEALS cohort to describe these relationships by race. The identification of modifiable risk factors for food allergy may lead to development of interventions that can delay progression of the allergic march, thereby reducing risk of asthma or other atopic diseases. This exploratory proposal should result in new paradigms of disease risk that can be applied to an increasingly diverse population, and represents a unique opportunity to gain a more comprehensive picture of how inherited and environmental factors can interact with behavior to influence risk of IgE-mediated allergy to milk, egg, and peanut. Research on risk factors for IgE-mediated food allergy is limited. It is important to increase our knowledge of the causes of food allergy and how it progresses. In this study, we will use an existing birth cohort to explore how infant feeding practices can influence development of IgE-mediated food allergy to egg, milk, or peanut. We will take advantage of the racial diversity in this study population to explore these relationships by race.

描述（由申请人提供）：对 IgE 介导的食物过敏的危险因素的研究有限。鉴于食物过敏通常是特应性的首发表现，因此增加我们对食物过敏病因和进展的了解不仅很重要，而且还很重要。确定短暂性与持续性 IgE 介导的食物过敏的危险因素，并最终利用这些信息制定干预措施，以预防过敏发生。该项目的总体目标是利用现有的出生情况。该研究的核心是与婴儿喂养方式相关的食物过敏风险，包括引入固体或补充食品的年龄以及与母乳喂养相关的因素。我们建议使用 2002 年由 NIAID 资助建立的韦恩县健康、环境和特应性纵向研究或 WHEALS 出生队列的数据。对于这些数据，拟议的研究将添加 (1) 一组数据过敏症专家将通过审查对队列中婴儿护理人员的访谈数据以及可用的临床数据来确定 IgE 介导的食物过敏，包括从出生起 - 2 年测量的血清总 IgE 和特异性 IgE 以及在 2017 年进行的皮肤点刺测试2 年；(2) 婴儿记录的医学图表审查，过敏症专科医生小组也可用于测定 IgE-FA；(3) 测量转化生长因子 β (TGF¿ ）和成熟母乳中的白细胞介素 10 (IL10) 这些活动不包括在当前 WHEALS 拨款的资助范围内，并且食物过敏和食物过敏都不是先前资助的 WHEALS 拨款目标 1 的结果。应用是估计 2 岁时 IgE 介导的食物过敏的患病率目的 2 是检查婴儿喂养方式与食物过敏患病率的关系，了解以下家族史。探索性目标 3 是利用病例对照研究来检查 IgE 介导的食物过敏患病率与转化生长因子 β (TGF¿) 浓度之间的关系。）和白细胞介素 10（IL10）在成熟母乳中的作用可能会导致开发出能够延缓过敏进展的干预措施，从而降低哮喘或其他特应性疾病的风险。这一探索性提议应该会产生新的疾病风险范式，可以应用于日益多样化的人群，并代表了一种独特的方法。有机会更全面地了解遗传因素和环境因素如何与行为相互作用，从而影响 IgE 介导的牛奶、鸡蛋和花生过敏风险。对 IgE 介导的食物过敏的危险因素的研究有限，增加我们对食物过敏的原因及其进展的了解非常重要。在这项研究中，我们将利用现有的出生队列来探讨婴儿喂养方式如何影响。 IgE 介导的对鸡蛋、牛奶或花生的食物过敏的发生我们将利用本研究人群的种族多样性来按种族探索这些关系。