The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception

精神分裂症妄想的神经基础：情绪感知的研究

基本信息

批准号：
8032848
负责人：
DAPHNE J HOLT
金额：
$ 5.4万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-01 至 2011-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8032848
关键词：
Address Affective Affective Symptoms Amygdaloid structure Animals Behavior Behavioral Brain Brain region Clinical Clinical Research Cognitive Cognitive deficits Corpus striatum structure Daphne plant Data Delusions Detection Early Diagnosis Eating Emotional Ethics Evaluation Event Exhibits Face Facial Expression Functional Magnetic Resonance Imaging Goals Hippocampus (Brain)Human Individual Instruction Intervention K-Series Research Career Programs Lead Learning Link Magnetic Resonance Imaging Measures Medial Mentors Methods Modeling National Institute of Mental Health Patients Perception Pharmaceutical Preparations Play Prefrontal Cortex Psychotic Disorders Relative (related person)Research Research Personnel Rest Role Schizophrenia Severities Signal Detection Analysis Spin Labels Stimulus Structure Symptoms Techniques Temporal Lobe Testing Training abstracting affective neuroscience base blood oxygen level dependent cognitive neuroscience design emotional stimulus experience hemodynamics interest method development neuroimaging patient oriented research prevent programs psychologic relating to nervous system research study response therapy design tool

项目摘要

DESCRIPTION (provided by applicant): This is an application for an NIMH Patient-Oriented Research Career Development Award (K-23) entitled "The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception." The candidate's interest is in the study of the neural correlates of psychotic symptoms in schizophrenia, with a specific focus on delusions. Previous studies indicate that patients with schizophrenia with active delusions exhibit abnormalities in emotional perception. A network of brain regions, which includes the amygdala, hippocampus, medial prefrontal cortex, and striatum, is active during emotional perception in healthy individuals. The candidate will test two hypotheses: 1) delusions arise from an increased tendency to attribute emotional significance to emotionally neutral or ambiguous information, and 2) this tendency results from abnormal neural activity within the network of brain regions involved in emotional perception. To address the research questions arising from this model, the candidate seeks training in cognitive and affective neuroscience, functional neuroimaging techniques, the statistical analyses of clinical, psychological and neuroimaging data, and the ethical conduct of clinical research. The proposed research plan, didactic courses, and individual instruction from mentors, advisors and consultants will help the candidate develop into an independent clinical researcher in the functional neuroimaging of emotional perception in schizophrenia. The candidate proposes to identify the specific abnormality in emotional perception in delusional schizophrenia patients using signal detection analyses to quantify a delusion-associated bias towards attributing emotional significance to neutral or ambiguous information. Experiments using two types of functional magnetic resonance imaging (blood oxygenation level dependent and arterial spin labeling) will be conducted to identify the changes in brain responses and resting neural activity associated with emotional perception abnormalities in delusional patients. Thus, the proposed experiments will test the candidate's model of delusions using the complementary techniques of cognitive neuroscience and functional magnetic resonance imaging. It is hoped that, by identifying perceptual and neural markers of delusions, these studies will lead to the development of methods for the detection of early, evolving psychosis. Such early detection methods would provide critical tools for the design of treatment interventions aimed at reducing the severity or preventing the onset of schizophrenia and other psychotic disorders.

描述（由申请人提供）：这是NIMH以患者为导向的研究职业发展奖（K-23）的申请，题为“精神分裂症的妄想的神经基础：情感知觉研究”。候选人的兴趣是研究精神分裂症中精神病症状的神经相关性，特别关注妄想。先前的研究表明，具有活性妄想的精神分裂症患者在情绪感知中表现出异常。包括杏仁核，海马，内侧前额叶皮层和纹状体在内的大脑区域网络在健康个体的情绪感知期间活跃。候选人将检验两个假设：1）妄想是由于将情绪意义归因于情绪中性或模棱两可的信息而增加的趋势，以及2）这种趋势是由于在情感感知中涉及的大脑区域网络中异常的神经活动引起的趋势。为了解决该模型引起的研究问题，候选人寻求培训认知和情感神经科学，功能性神经影像学技术，临床，心理和神经成像数据的统计分析以及临床研究的道德行为。拟议的研究计划，教学课程以及导师，顾问和顾问的个人指导将帮助候选人发展成为精神分裂症情感感知功能神经影像学的独立临床研究人员。候选人建议使用信号检测分析来确定妄想精神分裂症患者情绪感知中的特定异常，以量化与妄想相关的偏见，以将情绪意义归因于中性或模棱两可的信息。将进行两种类型的功能磁共振成像（血液氧合水平和动脉自旋标记）的实验，以确定妄想患者中与情绪感知异常相关的脑反应和静止神经活动的变化。因此，提出的实验将使用认知神经科学和功能磁共振成像的互补技术测试候选人的妄想模型。希望通过识别妄想的感知和神经标记，这些研究将导致开发检测早期，不断发展的精神病的方法。这种早期检测方法将为设计干预措施的设计提供关键的工具，以减轻严重程度或防止精神分裂症和其他精神病性疾病的发作。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia.

DOI：
10.1001/jamapsychiatry.2014.3176
发表时间：
2015-06
期刊：
JAMA psychiatry
影响因子：
25.8
作者：
Mueller S;Wang D;Pan R;Holt DJ;Liu H
通讯作者：
Liu H

Neural responses during social reflection in relatives of schizophrenia patients: relationship to subclinical delusions.

DOI：
10.1016/j.schres.2014.05.033
发表时间：
2014-08
期刊：
SCHIZOPHRENIA RESEARCH
影响因子：
4.5
作者：
Brent, Benjamin K.;Seidman, Larry J.;Coombs, Garth, III;Keshavan, Matcheri S.;Moran, Joseph M.;Holt, Daphne J.
通讯作者：
Holt, Daphne J.

Lack of insula reactivity to aversive stimuli in schizophrenia.