Add Health Parent Study: Phase I

添加健康家长研究：第一阶段

• 批准号: 8506381
• 负责人: Kathleen Mullan Harris
• 金额: $ 128.18万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8506381
• 关键词: Address; Adolescent; Adult Children; Affect; Archives; Behavioral; Biological; Biological Markers; Blood; Blood Pressure Monitors; Child; Cognition; Cognitive; Collection; Communities; Computers; Coupled; DNA; Data; Data Collection; Data Quality; Data Set; Decision Making; Device or Instrument Development; Divorce; Economics; Employment; Environment; Environmental Risk Factor; Family; Family dynamics; Fathers; Funding; Future; Generations; Genetic; Genetic Markers; Genetic Predisposition to Disease; Geographic Locations; Goals; Health; Health behavior; Health education; Heritability; Household; Income; Individual; Interview; Life; Link; Location; Longitudinal Studies; Measurement; Measures; Monitor; Mothers; Parenting behavior; Parents; Pattern; Personality; Personality Traits; Persons; Phase; Play; Procedures; Protocols documentation; Recording of previous events; Remarriages; Research; Research Personnel; Resources; Respondent; Retirement; Risk; Role; Saliva; Sampling; Scientist; Shapes; Shock; Specimen; Spottings; Surveys; Testing; Time; Work; base; behavioral health; cognitive function; data management; design; early adolescence; field survey; grandchild; innovation; intergenerational; laptop; member; offspring; phase 1 study; population based; preference; psychologic; public health relevance; social; trait

DESCRIPTION (provided by applicant): This application launches the first phase of data collection on the Add Health Parent Study (Add Health-PS). The Add Health-PS is an innovative project in which an interdisciplinary team of scientists will gather and analyze social, behavioral, and biological data on the parents of the members of the National Longitudinal Study of Adolescent Health (Add Health). Add Health-PS will leverage the rich longitudinal data on the original Add Health respondents to capture, for the first time, biological, genetic and social data on two linked generations. These unique set of data will support the study intergenerational linkages in three substantive domains: (i) health, functionality, and health behaviors; (ii) cognitive functioning, personality traits and preferences; and (iii) family suppor, relationship quality and ties of obligation. To address this scientific objective, data collection n Add Health-PS begins with these four Specific Aims: 1) Sample Selection & Location: Select, trace and locate a total sample of 5,000 parents of Add Health respondents, consisting of a random sample of 3,125 parents (mainly mothers) who were interviewed 16 years ago with their adolescent child in the Wave I of Add Health and an anticipated 1,875 "2nd parents" (mainly fathers) who currently live with that Wave I parent, were present in the household Add Health household at Wave I, but were not interviewed at that time. 2) Design Survey & Biomarker Collection: Develop a 60-minute CAPI/CASI survey instrument to be administered on a laptop computer, protocols for a 30-minute collection of physical measurements and biological specimens, and procedures to record and geocode spatial data obtained at the interview. Instrument development and choice of biomarkers will be guided by a strong interdisciplinary Design Team that will produce needed measures to address the scientific objectives for research noted above. 3) Field Survey & Collect Biomarkers: Conduct a 90-minute in-person interview with each Add Health parent in our target sample during which the following data are collected: survey data, anthropometric data, biological data from blood spot and saliva specimens and a blood pressure monitor, genetic data from DNA, and geographic locations for spatial data. We plan to collect the same biomarkers, cognitive, personality and related assessments that were collected on their offspring in past and planned future waves of Add Health. This field work will be spread over the five years of the project. 4) Data Management, Dissemination & Specimen Archiving: Monitor data quality during fieldwork to trouble-shoot in real time, clean and document survey data and biomarker protocols, prepare and disseminate data to Add Health-PS investigators and the scientific community of Add Health users, and maintain a bio- logical specimen archive for future testing.

描述（由申请人提供）：本申请启动了添加健康父母研究（ADD HEALTH-PS）的数据收集的第一阶段。 Add Health-PS是一个创新的项目，一个跨学科的科学家团队将聚集并分析社会， 行为，以及有关青少年健康纵向研究成员父母的生物学数据（添加健康）。添加Health-Ps将利用原始添加健康受访者的丰富纵向数据来捕获两个链接的世代的生物学，遗传和社交数据。 这些独特的数据集将支持研究三个实质领域中的代际联系：（i）健康，功能和健康行为； （ii）认知功能，人格特质和偏好； （iii）家庭支持，关系质量和义务联系。为了解决这一科学目标，数据收集n添加健康PS始于这四个具体目的：1）样本选择和位置：选择，跟踪和定位5,000名父母的总样本，包括3,125个父母（主要是母亲）的随机样本，由16年前在16年前接受了与他们的青春期和预期的人的青春期一起接受采访的人，他们是1,875的浪潮，而这是一位预期的。父母在第一波的家庭添加健康家庭中出现，但当时尚未接受采访。 2）设计调查与生物标志物收集：开发一个60分钟的CAPI/CASI调查工具，将在笔记本计算机上管理，用于收集30分钟的物理测量和生物标本的协议，以及在访谈中获得的记录和地理位置空间数据的程序。仪器的开发和选择生物标志物的选择将由一个强大的跨学科设计团队指导，该团队将制定所需的措施来解决上述研究的科学目标。 3）现场调查和收集生物标志物：对我们的目标样本中每个添加健康父母进行90分钟的面对面访谈，在此收集以下数据：调查数据，人体测量数据，血液点和唾液样本的生物学数据以及血压监测器，DNA的遗传数据以及空间数据的地理位置。我们计划收集过去的生物标志物，认知，个性和相关评估，这些评估是在过去的后代中收集的，并计划了将来的增加健康浪潮。这项现场工作将分布在该项目的五年中。 4）数据管理，传播和标本归档：监视现场工作期间的数据质量，以实时进行故障，清理和记录调查数据和生物标志物协议，准备和传播数据以添加健康PS调查人员以及添加健康用户的科学界，并维护生物逻辑标本，以进行未来测试。