Support for Human Specimen Banking in NCI-Sponsored Clinical Trials-(CGB)

对 NCI 资助的临床试验中的人体样本库的支持 - (CGB)

• 批准号: 8533991
• 负责人: NILSA DEL CARMEN RAMIREZ MILAN
• 金额: $ 49.99万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-03 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8533991
• 关键词: Acute Lymphocytic Leukemia; Acute Myelocytic Leukemia; Adolescent; Basic Science; Biological; Cancer Patient; Cancer Therapy Evaluation Program; Child; Childhood; Childhood Cancer Survivor Study; Children' s Oncology Group; Client; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Collection; Conduct Clinical Trials; Cooperative Human Tissue Network; Data; Emerging Technologies; Enrollment; Ensure; Fred Hutchinson Cancer Research Center; Funding; Grant; Gynecologic Oncology Group; Housing; Human; Laboratories; Link; Malignant Childhood Neoplasm; Malignant Neoplasms; Molecular; Molecular Profiling; Neuroblastoma; Ohio; Patients; Pediatric Hospitals; Play; Procedures; Protocols documentation; Quality Control; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Role; Rosa; Solid; Specimen; Survival Rate; Testing; Therapeutic; Tissue Banking; Tissue Banks; Translational Research; Treatment outcome; United States; Washington; Work; biobank; improved; mortality; patient population; population based; racial and ethnic; research clinical testing; research study; success; treatment trial

DESCRIPTION (provided by applicant): Over 90% of United States and Canadian children and adolescents with cancer are enrolled in Children's Oncology Group (COG) clinical trials with no racial, ethnic or geographic bias to registration, allowing for near- population-based clinical, translational and basic research. Clinical trials conducted by COG and its antecedent organizations have played a major role in these advances and will continue to drive the improvements projected to come in the next decade. The biospecimens collected during these clinical treatment trials are crucial to their success. These biospecimens are sent to centralized laboratories for clinical testing and banking for future research use. The Biopathology Center (BPC) is part of the Research Institute at Nationwide Children's Hospital in Columbus, Ohio and houses the COG Solid Tissue Bank as well as the COG ALL Molecular Reference Laboratory and Bank. The COG AML Reference Laboratory and Bank is located at the Fred Hutchinson Cancer Research Center Seattle, Washington. Currently, the BPC is federally funded to serve several clients (including the Pediatric Division of the Cooperative Human Tissue Network [pCHTN], and the biobanking efforts of the Gynecologic Oncology Group [GOG], the Childhood Cancer Survivor Study [CCSS], and the Cancer Therapy Evaluation Program [CTEP]). To accomplish this, the banks continue to work with the aims of the original grant submission in 2004. 1. Establish collection, storage and quality control procedures for tissue banking in pediatric cancer patients that are near-population-based. 2. Ensure proper storage and quality control procedures for pediatric tissue bank biospecimens that promote outstanding retrospective translational research. 3. Ensure proper administration of tissue bank resources to facilitate investigator access to biospecimens. 4. Promote linkage of tissue bank resources to existing demographic, clinical, and biological, treatment and outcome data. 5. Optimize utilization of finite tissue bank resources utilizing emerging technologies.

描述（由申请人提供）：超过90％的美国和加拿大儿童和青少年患有癌症的儿童肿瘤学小组（COG）临床试验，没有种族，种族或地理偏见，可以进行注册，从而允许近人群的临床，转换，转化和基础研究。 COG及其先例组织进行的临床试验在这些进步中发挥了重要作用，并将继续推动预计将在未来十年内进行的改进。在这些临床治疗试验期间收集的生物测量对于它们的成功至关重要。这些生物测量被送往集中实验室进行临床测试和银行业务，以供未来的研究使用。生物病理学中心（BPC）是俄亥俄州哥伦布市全国儿童医院研究所的一部分，并设有COG固体组织库以及COG所有分子参考实验室和银行。 COG AML参考实验室和银行位于华盛顿西雅图的弗雷德·哈钦森癌症研究中心。目前，BPC旨在为几个客户提供服务（包括合作人组织网络[PCHTN]的儿科划分，以及妇科肿瘤学小组[GOG]的生物群体工作[GOG]，儿童癌症幸存者研究[CCSS]和癌症治疗评估计划[CTEP]）。为此，银行继续与2004年原始赠款提交的目标合作。1。为小儿癌症患者的组织库建立收集，存储和质量控制程序，这些程序几乎是基于人口的。 2.确保针对小儿组织库生物测量的适当存储和质量控制程序，以促进出色的回顾性转化研究。 3.确保适当地管理组织库资源，以促进研究人员获得生物测量。 4。促进组织库资源与现有人口，临床和生物学，治疗和结果数据的联系。 5。优化利用新兴技术的有限组织库资源。