Biospecimen Processing and Storage Core

生物样本处理和存储核心

基本信息

批准号：
10289497
负责人：
Terzah M Horton
金额：
$ 18.71万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-20 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10289497
关键词：
Acute Lymphocytic Leukemia Acute Myelocytic Leukemia Acute leukemia Adolescent Adult Aliquot Applications Grants Biological Factors Biology Blood Blood specimen Bone Marrow Bone Marrow Cells Cancer Center Catalogs Cells Cerebrospinal Fluid Child Childhood Acute Lymphocytic Leukemia Clinical Clinical Trials Code Collection Comprehensive Cancer Center Core Facility DNA Data Databases Development Doctor of Philosophy Ensure Ethnic group Freezing Frequencies Future Genetic Goals Grant Health Hepatotoxicity Hodgkin Disease Information Storage Latino Leukocytes Liquid substance Location Malignant Neoplasms Medicine Methotrexate Mononuclear Patients Pediatric Oncology Group Pediatrics Peripheral Blood Mononuclear Cell Pilot Projects Plasma Population Sciences Postdoctoral Fellow Procedures Process Research Research Project Grants Research Support Resources Sampling Services Shipping Ships Site Specimen Texas Therapeutic Time Tissues Translational Research Treatment-related toxicity Tumor Biology Vulnerable Populations biobank cancer health disparity cancer prevention central database college ethnic disparity experience experimental study health disparity improved outcome insight leukemia/lymphoma member mid-career faculty neurotoxicity peripheral blood professor programs racial and ethnic recruit sample collection social health determinants tenure track translational research program translational study

项目摘要

PROJECT SUMMARY Biospecimen Processing and Storage Core (Core B) The proposed cancer health disparities translational research program in this P20 planning grant application relies on the submission of serial peripheral blood, bone marrow and cerebrospinal fluid (CSF) specimens from children and adolescents with acute lymphoblastic leukemia (ALL) across the participating clinical recruitment sites of the Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium. The Biospecimen Processing and Storage Core (BPSC) will serve as the central location where these samples will be processed into the materials needed for the specific studies in Research Projects 1 (treatment-associated hepatotoxicity) and 2 (methotrexate neurotoxicity), as well as determination of genetic ancestry for use across all projects, and biobanking of material that will be available for pilot projects through the Developmental Research Program (DRP). This Core will support the collection, shipping, processing, and storage of patient samples from each study site, as well as provide up-to-date and accurate sample annotation. The Core will follow previously developed standard operating procedures to ensure uniform collection and processing for optimal sample yield and quality. The Aims of the Core are to: 1) Receive and catalog blood, bone marrow and CSF provided by the Consortium sites; 2) Process all patient samples to isolate plasma, peripheral blood mononuclear cells, and bone marrow mononuclear cells, and separate blasts from non-blasts where appropriate; 3) Allocate and distribute samples to Projects; and 4) Maintain a biobank of samples for future research. The resulting biobank will become an extremely valuable resource for this and future translational studies examining ethnic disparities in childhood ALL.

项目摘要生物测量处理和存储核心（核心B）拟议的癌症健康差异转化研究计划中的P20计划赠款应用依赖于提交系列外周血，骨髓和脑脊液（CSF）来自儿童和青少年患有急性淋巴细胞白血病（全部）的标本参与急性白血病种族差异的临床招聘部位（REDIAIL）财团。生物循环处理和存储核心（BPSC）将作为中心位置这些样品将被处理成研究的特定研究所需的材料项目1（与治疗相关的肝毒性）和2（甲氨蝶呤神经毒性）以及确定遗传祖先用于在所有项目中使用，以及材料的生物群通过发展研究计划（DRP）可用于试点项目。这个核心将支持每个研究站点的患者样品的收集，运输，处理和存储以及提供最新和准确的样品注释。核心将遵循先前开发的标准操作程序以确保收集和处理统一，以获得最佳的样本收率和质量。核心的目的是：1）接收和分类血液，骨髓和CSF由财团地点； 2）处理所有患者样品以分离血浆，外周血单核细胞，和骨髓单核细胞，并在适当的情况下将爆炸与非爆炸分开； 3）分配并将样本分发给项目； 4）维护样本的生物库，以供将来研究。结果生物库将成为研究和将来的翻译研究的极其宝贵的资源童年时代的种族差异。