2013 Neurofibromatosis (NF) Conference

2013年神经纤维瘤病（NF）会议

基本信息

批准号：
8595702
负责人：
Scott R Plotkin
金额：
$ 1.3万
依托单位：
CHILDREN'S TUMOR FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-08 至 2014-06-06
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8595702
关键词：
Address Affect American Area Award Basic Science Benign Birth Blindness Books Brain California Cellular biology Child Child Support Clinic Clinical Clinical Sciences Clinical Trials Cognitive Collaborations Communities Congenital Heart Defects Consensus Continuing Education Critiques Defect Disease Doctor of Medicine Doctor of Philosophy Educational workshop Ensure Evaluation Family history of Film Fostering Foundations Funding Genes Genetic Genomics Germ Lines Goals Growth Hereditary Disease Histologic Individual International Interview Journals Learning Learning Disabilities Link Malignant - descriptor Malignant Neoplasms Marketing Medical Genetics Medical Research Molecular Molecular Biology Morbidity - disease rate Mutation NF1 gene Nervous system structure Neurofibromatoses Neurofibromatosis 2 Neurofibromin 2 Neuropathy Neurosciences Newsletter Nurses Operative Surgical Procedures Outcome Pain Pathway interactions Peer Review Persons Pharmaceutical Preparations Pharmacotherapy Phase Physicians Plant Roots Play Professional counselor Publications Publishing Reporting Request for Applications Research Research Personnel Role SMARCB1 gene Schwannomatosis Scientist Signal Pathway Signal Transduction Source Summary Reports Syndrome Therapeutic Time Translational Research Tumor Suppressor Proteins United States National Institutes of Health Update Vertebral column Work abstracting anticancer research bench to bedside bone cancer cell clinical phenotype design gene cloning improved interest lectures medical specialties meetings mortality nervous system disorder posters pre-clinical programs public health relevance response symposium therapy development tumor web site working group

项目摘要

DESCRIPTION (provided by applicant): The Neurofibromatosis (NF) Conference has been organized by the Children's Tumor Foundation (CTF) annually since 1985. With its roots in a small workshop-style gathering of a group called the "NF Consortium" dedicated to cloning the genes underlying the Neurofibromatoses, the NF Conference has grown to a gathering of well over 350 NF researchers and clinicians from around the world. This meeting is recognized as the premier annual gathering of international NF researchers and physicians. Major contributors to this growth are the significant advances made in NF research in recent years and, particularly, recent advances into clinical trials and drug therapy development. In addition, state of-the-art genomic approaches have identified mutations in the NF genes as contributors to numerous types of sporadic cancers. Signaling pathways including the Hippo and Ras cascades are implicated in NF, and it is now recognized that mutations in genes along the Ras pathway result in a set of disorders, including NF1, called the "Rasopathies". Traditionally a forum for research information exchange and consensus building, in recent years the NF Conference is also the principal international forum for reporting on the neurofibromatosis preclinical therapeutic pipeline and the expanding arena of neurofibromatosis clinical trials. Children's Tumor Foundation: 2013 NF Conference PI: Plotkin, Scott, M.D. 1

描述（由申请人提供）：自 1985 年以来，神经纤维瘤病 (NF) 会议每年由儿童肿瘤基金会 (CTF) 举办。其根源在于一个名为“NF 联盟”的致力于克隆的团体的小型研讨会式聚会神经纤维瘤病背后的基因，神经纤维瘤会议已发展到聚集了来自世界各地的 350 多名神经纤维瘤研究人员和临床医生。这次会议被认为是国际神经纤维瘤研究人员和医生的首要年度聚会。这一增长的主要贡献者是近年来 NF 研究取得的重大进展，特别是临床试验和药物治疗开发的最新进展。此外，声明最先进的基因组方法已确定 NF 基因突变是多种散发性癌症的诱因。包括 Hippo 和 Ras 级联在内的信号通路与 NF 相关，现在人们认识到 Ras 通路上的基因突变会导致一系列疾病，包括 NF1，称为“Rasopathies”。传统上，NF 会议是研究信息交流和建立共识的论坛，近年来，它也是报告神经纤维瘤病临床前治疗管道和不断扩大的神经纤维瘤病临床试验领域的主要国际论坛。儿童肿瘤基金会：2013 NF 会议 PI：Plotkin, Scott, M.D. 1