Magnetic Particle Imaging Angiography for Chronic Kidney Disease Patients

慢性肾病患者的磁粒子成像血管造影

• 批准号: 8163028
• 负责人: STEVEN M CONOLLY
• 金额: $ 43.4万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8163028
• 关键词: Acceleration; American; Anemia; Angiography; Caliber; Chronic Kidney Failure; Computer software; Contrast Media; Custom; FDA approved; Fibrosis; Gadolinium; Human; Image; Injection of therapeutic agent; Intravenous; Iodine; Ionizing radiation; Kidney Diseases; Magnetic Resonance Imaging; Magnetism; Measures; Medical; Methods; Mus; Patients; Physiologic pulse; Relaxation; Renal function; Research; Resolution; Roentgen Rays; Scanning; Speed; Staging; Testing; Time; Tissues; Venous; X-Ray Computed Tomography; abdominal aorta; design; ferumoxtran; gadolinium oxide; high risk; imaging modality; improved; in vivo; innovation; instrument; iron oxide; mouse model; nanoparticle; novel; particle

DESCRIPTION (provided by applicant): We will develop hardware, software and novel contrast agents for a new angiographic imaging modality called Magnetic Particle Imaging, which is completely different from X-ray, CT and MRI. Currently available angiographic contrast agents (iodine for X-ray and gadolinium for MRI) are dangerous for Chronic Kidney Disease patients. Magnetic Particle Imaging offers excellent image quality and the contrast agents are completely safe for Chronic Kidney Disease patients. This research will remove the final obstacles to a major medical breakthrough for Chronic Kidney Disease patients. PUBLIC HEALTH RELEVANCE: We will develop hardware, software and novel contrast agents for a new angiographic imaging modality called Magnetic Particle Imaging, which is completely different from X-ray, CT and MRI. Currently available angiographic contrast agents (iodine for X-ray and gadolinium for MRI) are dangerous for Chronic Kidney Disease patients; Magnetic Particle Imaging offers excellent image quality and the contrast agents are completely safe for Chronic Kidney Disease patients. This research will remove the final obstacles to a major medical breakthrough for Chronic Kidney Disease patients.

描述（由申请人提供）：我们将为一种称为磁粒子成像的新型血管造影成像方式开发硬件、软件和新型造影剂，该方式与 X 射线、CT 和 MRI 完全不同。目前可用的血管造影造影剂（用于 X 射线的碘和用于 MRI 的钆）对慢性肾病患者来说是危险的。磁粒子成像可提供出色的图像质量，并且造影剂对于慢性肾脏病患者来说是完全安全的。这项研究将为慢性肾脏病患者的重大医学突破扫除最后的障碍。 公共健康相关性：我们将为称为磁粒子成像的新型血管造影成像方式开发硬件、软件和新型造影剂，该成像方式与 X 射线、CT 和 MRI 完全不同。目前可用的血管造影造影剂（用于 X 射线的碘和用于 MRI 的钆）对慢性肾病患者来说是危险的；磁粒子成像可提供出色的图像质量，并且造影剂对于慢性肾脏病患者来说是完全安全的。这项研究将为慢性肾脏病患者的重大医学突破扫除最后的障碍。