Physiology of Inflammatory Arthritis in High Resolution

高分辨率炎症性关节炎的生理学

• 批准号: 8513127
• 负责人: XUEDING WANG
• 金额: $ 46.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-06 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8513127
• 关键词: Acute; Affect; Animals; Antirheumatic Agents; Arthritis; Biochemical; Biological Markers; Blood; Blood Volume; Bone Tissue; Cadaver; Chronic; Clinical; Clinical Management; Collaborations; Contrast Media; Development; Devices; Diagnosis; Digit structure; Disease; Early identification; Elements; Functional disorder; Gadolinium; Genetic; Goals; Gold; Human; Hyperemia; Hypoxia; Image; Imaging technology; Inflammatory; Intervention; Joints; Lasers; Lead; Length; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Medical; Modality; Modeling; Molecular; Monitor; Onset of illness; Optics; Organ; Patients; Performance; Peripheral; Pharmacologic Substance; Physicians; Physiological; Physiology; Property; Protocols documentation; Rattus; Real-Time Systems; Research; Research Personnel; Resolution; Resources; Rheumatoid Arthritis; Scanning; Sensitivity and Specificity; Signal Transduction; Specimen; Speed; Structure; Swelling; Synovial Membrane; Synovitis; System; Techniques; Technology; Therapeutic; Three-Dimensional Imaging; Time; Tissues; Transducers; Treatment Efficacy; Ultrasonic Transducer; Ultrasonics; Ultrasonography; United States National Institutes of Health; Validation; arthropathies; base; bone; clinical practice; cost; cost effective; design; gadolinium oxide; hemodynamics; imaging modality; improved; in vivo; innovation; instrument; interest; nanoparticle; novel; photoacoustic imaging; research study; response; soft tissue; spectroscopic imaging; technology development; tomography; uptake; volunteer

DESCRIPTION (provided by applicant): Development and application of new imaging technologies for the discovery of biomarkers of inflammatory arthritic disease onset, progression, and response to therapy are of broad interest and are common goals of physicians, medical researchers and scientific entities such as the NIH. Presenting high resolution optical information in soft tissues with imaging depth up to several centimeters, innovative spectroscopic photoacoustic tomography (SPAT) offers significant benefits to the diagnosis and treatment of inflammatory arthritis, particularly in combination with more established ultrasound imaging (US). SPAT, in addition to capturing peripheral bone and soft tissue images, has the unique capability to quantify tissue hemodynamic properties including regional blood oxygenation and blood volume, both abnormal in synovial tissue associated with inflammatory arthritis. Therefore, findings from SPAT should lead to creation of new direct and sensitive tissue-specific biomarkers, and may have revolutionary impact on clinical management of arthritis. Based on our past validation in animals and human cadaver joints, this physiological imaging modality will be adapted to human inflammatory arthritis for the first time in the proposed research. Through collaboration with the NIH Ultrasonic Transducer Resource Center, we will develop a specially designed SPAT and US dual-modality system employing the state-of-the-art ultrasonic imaging and transducer development technologies. This system will enable simultaneous SPAT and US imaging of human peripheral joints in real-time. Moreover, it can present physicians with both optical and ultrasonic contrast as well as tissue physiological information. Through the experiments on normal volunteers and rheumatoid arthritis patients, we will examine the performance of SPAT and US in imaging the articular tissue structures of peripheral joints and their ability in visualizing morphological biomarkers of rheumatoid arthritis. More interestingly, we will explore the potential of SPAT in assessing new physiological biomarkers of synovitis including hyperemia and hypoxia. We expect that, with sensitivity and specificity comparable to MRI but without using a contrast agent, this cost-effective imaging may provide unique opportunities for arthritis, including pre-diagnosis, identification of initial natural disease sequelae and progression, along with monitoring of non-pharmaceutical and pharmaceutical based interventions.

描述（由申请人提供）：开发和应用新成像技术在发现炎症性关节炎发作，进展和对治疗的反应的生物标志物中具有广泛的兴趣，并且是医师，医学研究人员和科学实体（例如NIH）的共同目标。创新的光谱光声断层扫描（SPAT）在软组织中提供高分辨率的光学信息，可为炎症性关节炎的诊断和治疗带来重大好处，尤其是与更具成熟的超声影像（美国）相结合（美国）。除了捕获外周骨和软组织图像外，吐口水具有量化组织血液动力学特性在内的独特能力，包括区域血氧和血容量，这两者在与炎症性关节炎相关的滑膜组织异常。因此，吐口水的发现应导致创建新的直接和敏感的组织特异性生物标志物，并可能对关节炎的临床管理产生革命性的影响。基于我们过去在动物和人尸体关节中的验证，这种生理成像方式将在拟议的研究中首次适应人类炎症性关节炎。通过与NIH超声波传感器资源中心的合作，我们将使用最先进的超声成像和传感器开发技术开发专门设计的吐痰和美国双模式系统。该系统将实时同时吐口水和我们对人类外围关节的成像。此外，它可以向医生提供光学和超声对比度以及组织生理信息。通过对正常志愿者和类风湿关节炎患者的实验，我们将研究Spat和我们在成像外周关节的关节组织结构中的性能，以及它们可视化类风湿关节炎的形态生物标志物的能力。更有趣的是，我们将探讨吐口水在评估滑膜炎的新生理生物标志物（包括充血和缺氧）中的潜力。我们预计，通过与MRI相当的敏感性和特异性，但不使用造影剂，这种具有成本效益的成像可能会为关节炎提供独特的机会，包括诊断前，鉴定初始自然疾病后遗症和进展，以及监测非药物的基于非药物和基于药物的干预措施。