Childhood health disparities: exploration of prenatal exposures in primary teeth

儿童期健康差异：乳牙产前暴露的探索

• 批准号: 8429805
• 负责人: Andrea E Cassidy-Bushrow
• 金额: $ 25.36万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8429805
• 关键词: 2 year old; Ablation; Accounting; Adult; Age; Allergic; Allergic Disease; Area; Arsenic; Asthma; Barker Hypothesis; Birth; Birth Weight; Cadmium; Child; Child health care; Childhood; Chronic Disease; County; Coupled; Data; Development; Early identification; Early treatment; Environment; Fetal Development; Fetus; Future; Geographic Locations; Gestational Age; Goals; Health; Health Policy; Health system; Human; Hypersensitivity; Image; Immune system; Industry; Lasers; Lead; Life; Longitudinal Studies; Manganese; Maps; Mass Spectrum Analysis; Measures; Mercury; Metal exposure; Metals; Methods; Minority; Outcome; Participant; Phenotype; Plant Roots; Plasma; Pollution; Predisposition; Premature Birth; Prevention strategy; Public Health; Race; Recruitment Activity; Reliance; Research Personnel; Role; Sampling; Socioeconomic Status; Source; Time; Tooth structure; Toxic Environmental Substances; Toxicant exposure; Woman; atopy; body system; cohort; deciduous tooth; early childhood; early life exposure; fetal; fetal lead exposure; health disparity; high risk; improved; interest; metropolitan; novel; novel strategies; postnatal; prenatal; prenatal exposure; prenatal risk factor; public health relevance; racial difference; segregation; social; socioeconomics; suburb; theories; toxicant; trait; 2 year old; Ablation; Accounting; Adult; Age; Allergic; Allergic Disease; Area; Arsenic; Asthma; Barker Hypothesis; Birth; Birth Weight; Cadmium; Child; Child health care; Childhood; Chronic Disease; County; Coupled; Data; Development; Early identification; Early treatment; Environment; Fetal Development; Fetus; Future; Geographic Locations; Gestational Age; Goals; Health; Health Policy; Health system; Human; Hypersensitivity; Image; Immune system; Industry; Lasers; Lead; Life; Longitudinal Studies; Manganese; Maps; Mass Spectrum Analysis; Measures; Mercury; Metal exposure; Metals; Methods; Minority; Outcome; Participant; Phenotype; Plant Roots; Plasma; Pollution; Predisposition; Premature Birth; Prevention strategy; Public Health; Race; Recruitment Activity; Reliance; Research Personnel; Role; Sampling; Socioeconomic Status; Source; Time; Tooth structure; Toxic Environmental Substances; Toxicant exposure; Woman; atopy; body system; cohort; deciduous tooth; early childhood; early life exposure; fetal; fetal lead exposure; health disparity; high risk; improved; interest; metropolitan; novel; novel strategies; postnatal; prenatal; prenatal exposure; prenatal risk factor; public health relevance; racial difference; segregation; social; socioeconomics; suburb; theories; toxicant; trait

DESCRIPTION (provided by investigator): Differences in prenatal exposures may account for some of the racial disparities observed in health outcomes; however, studies have been hampered by a lack of a reliable means of examining such retrospective exposures. A novel method, elemental bio-imaging of human primary teeth with laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), will be used to measure metal exposures in naturally sheed teeth of an established birth cohort. This approach not only quantifies exposure but also estimates the timing of the exposure (i.e. within trimester). We hypothesize there are identifiable critical windows of exposure aligned with gestational development of key organ systems that are specific for different child health outcomes. The proposed project builds on extant data collected through the racially and socioeconomically diverse Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS) birth cohort conducted between 2003 and 2007 in Detroit, MI and the surrounding suburban regions. From a subset of active WHEALS participants, 250 naturally shed primary teeth (230 unique children) will be collected and 5 metals (lead, cadmium, manganese, mercury, arsenic) will be measured with LA-ICP-MS. Our outcomes of interest are two traits demonstrating substantial racial disparities: birth weight and allergic disease measures at age 2 years. Our aims are to (1) examine if there are racial differences in early-life metal toxicant exposures; (2) examine if trimester-specific exposures to metal toxicants are associated with birth weight; and (3) examine if early-life exposures to metal toxicants are associated with allergic disease at age 2. Information gained by the proposed study may guide public health policy, improve prevention strategies, and lead to earlier identification and treatment of high-risk children with the overall goal to reduce health disparitis and improve the publics' heath.

描述（调查人员提供）：产前暴露的差异可能解释了健康结果中观察到的一些种族差异；但是，由于缺乏可靠的检查这种回顾性暴露的方法，研究受到了阻碍。一种新型的方法，即用激光消融诱导耦合等离子体质量光谱法（LA-ICP-MS）的人类原发性牙齿的元素生物形象，将用于测量既定出生同胞的自然染上牙齿中的金属暴露。这种方法不仅可以量化暴露量，而且还估计了暴露的时间（即孕期）。我们假设有可识别的 接触的关键窗口与关键器官系统的妊娠开发一致，这些系统特定于不同的儿童健康结果。拟议的项目建立在韦恩县卫生，环境，过敏和哮喘纵向研究（WHEALS）出生队列中通过种族和社会经济多样的数据收集的现有数据，该数据在2003年至2007年之间在底特律，密歇根州和周围的郊区进行了。将从一部分活跃的惠尔斯参与者的子集中，将收集250个自然脱落的牙齿（230个独特的儿童），并使用LA-ICP-MS测量5种金属（铅，镉，锰，汞，砷）。我们感兴趣的结果是两个特征，表明种族差异很大：2岁时出生体重和过敏性疾病措施。我们的目的是（1）检查早期金属有毒物质暴露的种族差异； （2）检查三个月对金属毒物的暴露是否与出生体重有关； （3）检查对金属有毒物质的早期暴露是否与2岁时的过敏性疾病有关。拟议的研究获得的信息可能指导公共卫生政策，改善预防策略，并导致对高危儿童的早期鉴定和治疗，其总体目标是减少健康疾病炎症并改善公众的heath。