Gene-Environment Interplay and Development of Psychiatric Symptoms in Children

基因-环境相互作用与儿童精神症状的发展

• 批准号: 8150328
• 负责人: Leslie Diane Leve
• 金额: $ 62.74万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-28 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8150328
• 关键词: 6 year old; Adolescence; Adolescent; Adoption; Adult; Age; Age-Years; Aggressive behavior; Alcohol or Other Drugs use; Anxiety; Area; Behavior; Behavioral; Behavioral Symptoms; Birth; Child; Child Behavior; Child Rearing; Childhood; Collection; DNA; Data; Data Collection; Data Set; Development; Diagnostic; Disease; Economics; Emotional; Emotions; Environment; Event; Exposure to; Family; Genes; Genetic; Genetic Predisposition to Disease; Genetic Risk; Growth and Development function; Guide prevention; High Prevalence; Home environment; Individual; Life; Link; Marital Relationships; Measurement; Measures; Mediating; Mental Depression; Mental disorders; Parenting behavior; Parents; Participant; Pathway interactions; Pattern; Phase; Prevalence; Primary Schools; Productivity; Recruitment Activity; Resource Allocation; Resources; Risk; Role; Sampling; Societies; Stress; Substance abuse problem; Symptoms; Temperament; Time; Work; adopted child; anti social; cohort; cost; depressive symptoms; design; early childhood; externalizing behavior; genetic risk factor; infancy; insight; longitudinal design; postnatal; prenatal; prenatal experience; prenatal exposure; prenatal influence; prenatal risk factor; prenatal stress; prospective; public health relevance; resilience

DESCRIPTION (provided by applicant): This project utilizes an adoption design to examine the interplay between genetic, prenatal, and postnatal environmental influences on early pathways to conduct, anxiety, and depressive problems by (a) conducting a psychiatric assessment of adopted children between 6.0 and 7.5 years of age and (b) conducting a psychiatric assessment of adoptive parents. Psychiatric assessments of the birth parents have already been conducted and these data will be utilized in the proposed analyses. In addition, DNA is being collected on all participants and will be available for analysis in the present study. The present study builds on a longitudinal prospective adoption study conducted during early childhood: two cohorts of adopted children and their birth and adoptive parents were recruited and assessed across 3 - 6 waves from infancy through early childhood (Early Growth and Development Study; EGDS-Cohort I, R01 HD42608 and EGDS-Cohort II, R01 DA020585). Combined with the rich existing data, the proposed data will allow us to better characterize early emerging emotional and behavioral symptoms in children that have been shown to predict later psychiatric problems. Because we will have DNA samples and data from birth and adoptive parents, we will be able to disentangle how prenatal, genetic, and rearing environment factors are related to early emerging emotional and behavioral symptoms, as well as to later psychiatric symptoms. To our knowledge, no other existing dataset or resource exists that can disentangle and examine the interplay among genetic, prenatal, and postnatal environmental influences on the development of symptoms in young children. The proposed study will allow us to achieve the following specific aims: SA1: Identify early emerging behaviors and emotions in children that predict onset of psychiatric symptoms in young children; SA2: Examine prenatal exposure to substances and prenatal stress in exacerbating genetic risk for psychiatric symptoms; SA3: Consider the mediating and moderating role of the rearing environment on prenatal and genetic risk factors on psychiatric symptoms in childhood; SA4: Assess how adoptive parents' stress and their own psychiatric symptoms impact the rearing environment and mediate and/or moderate genetic and prenatal influences. PUBLIC HEALTH RELEVANCE: Individuals with psychiatric disorders place an enormous burden on society in economic, resource allocation, and productivity, as well as individual and family-level costs. This study advances the ability to identify early behaviors and contexts that predict the development of psychiatric symptoms in young children. Identifying such behaviors and contexts can guide prevention efforts, thereby reducing the prevalence rates of disorder.

描述（由申请人提供）：该项目利用收养设计来检查遗传、产前和产后环境对早期行为、焦虑和抑郁问题的影响之间的相互作用，方法是 (a) 对 6.0 岁之间的收养儿童进行精神病学评估7.5 岁，并且 (b) 对养父母进行精神病学评估。已经对亲生父母进行了精神病学评估，这些数据将用于拟议的分析。此外，正在收集所有参与者的 DNA，并将用于本研究中的分析。本研究建立在幼儿期进行的纵向前瞻性收养研究的基础上：招募了两组被收养儿童及其出生和养父母，并在从婴儿期到幼儿期的 3 - 6 波中进行评估（早期生长和发育研究；EGDS-Cohort） I，R01 HD42608 和 EGDS-队列 II，R01 DA020585）。结合丰富的现有数据，拟议的数据将使我们能够更好地描述儿童早期出现的情绪和行为症状，这些症状已被证明可以预测以后的精神问题。因为我们将拥有来自出生父母和养父母的 DNA 样本和数据，所以我们将能够理清产前、遗传和抚养环境因素如何与早期出现的情绪和行为症状以及后来的精神症状相关。据我们所知，没有其他现有的数据集或资源可以理清和检查遗传、产前和产后环境对幼儿症状发展的影响之间的相互作用。拟议的研究将使我们能够实现以下具体目标： SA1：识别儿童早期出现的行为和情绪，以预测幼儿精神症状的发生； SA2：检查产前接触物质和产前压力是否会加剧精神症状的遗传风险； SA3：考虑抚养环境对产前和遗传危险因素对儿童精神症状的中介和调节作用； SA4：评估养父母的压力和他们自己的精神症状如何影响抚养环境以及介导和/或调节遗传和产前影响。 公共卫生相关性：患有精神疾病的个体在经济、资源分配和生产力以及个人和家庭层面的成本方面给社会带来了巨大的负担。这项研究提高了识别预测幼儿精神症状发展的早期行为和背景的能力。识别此类行为和背景可以指导预防工作，从而降低疾病的患病率。