Studies on the Prevalence, Risk Factors and Outcomes of Cancers in HIV in India

印度艾滋病毒感染者癌症患病率、危险因素和结果的研究

• 批准号: 8539193
• 负责人: RONALD T. MITSUYASU
• 金额: $ 16.51万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8539193
• 关键词: AIDS Malignancy Consortium; Acquired Immunodeficiency Syndrome; Affect; Awareness; Blood specimen; Breast; CD4 Lymphocyte Count; Cancer Center; Cancer Hospital; Cancer Patient; Cancer Prevention Trial; Cervical; Clinic; Clinical; Clinical Treatment; Clinical Trials; Collaborations; Comorbidity; Cross-Sectional Studies; Data; Databases; Development; Early Diagnosis; Educational process of instructing; Enrollment; Environmental Exposure; Epidemiology; Frequencies; Funding; Future; Goals; Grant; HIV; HIV Infections; HIV risk; Health; Hospital Referrals; Incidence; India; Individual; Infection; Institutes; Institution; Investigation; Laboratories; Malignant Neoplasms; Medical; Monitor; Morbidity - disease rate; Oncogenic Viruses; Outcome; Patients; Peripheral Blood Mononuclear Cell; Persons; Plasma; Population; Prevalence; Prevention strategy; Preventive Intervention; Prostate; Regional Cancer; Registries; Research; Research Personnel; Resources; Risk; Risk Factors; Science; Screening for cancer; Services; Source; Specimen; Staging; Surveys; Therapeutic; Therapeutic Intervention; Tissue Banking; Tissue Banks; Treatment outcome; Viral; Viral Epidemiology; Viral Load result; base; cancer risk; cancer therapy; cancer type; cohort; demographics; follow-up; improved; mortality; neoplasm registry; professor; prospective; public health relevance; repository; residence; sample collection; tumor; tumorigenesis

DESCRIPTION (provided by applicant): Globally, India has one of the largest populations of HIV-infected people, estimated at 2.40 million individuals. Malignancy is a known co-morbidity of HIV infection and is growing in proportion in many parts of the world. The incidence and manifestations of cancer in HIV-infected individuals in India has not yet been well characterized, and the proportion of patients with undiagnosed HIV infection who may be presenting with cancer as their first manifestation of HIV infection is not known. The goal of this proposal is to obtain information on the prevalence of HIV in the cancer population seen over a 1-2 year period at a major cancer treatment and referral center in Northern India. We will similarly assess the HIV prevalence of patients presenting to cancer screening clinics at the same institution (e.g. breast, cervical and prostate). Another goal is to collect information; demographics, HIV and clinical status at presentation, HIV and cancer risk factors, as well as information on incidence of cancer, cancer types, stage, treatments and treatment outcomes in patients with HIV and cancer. In addition we will similarly assess various cancer risk factors and the prevalence of various oncogenic viruses in patients with incident cancers (compared to concurrent control HIV+ individuals from the same HIV clinic at the same institution that do not develop cancer in the timeframe of this study. This will allow assessment of HIV prevalence in various cancers types as well as provide information on the short- term cancer incident and various risk factors and co-factors for cancer development among HIV-infected persons. Identified cancer and HIV individuals from this study will be enrolled in a cancer and HIV registry and specimen/tissue bank, which we will help establish, for prospective follow-up and specimen collection to obtain data on cancer and HIV treatments and clinical outcomes and to provide a cohort for future research studies, including epidemiologic, laboratory and possible clinical trial. Establishment of the HIV and cancer registry with collected tumor and blood specimens will provide our Indian investigator colleagues with a valuable resource for further research (with additional future Indian outside funding). This study will involve a collaboration between investigators at UCLA, the All India Institute for Medical Sciences (AIIMS) in New Delhi and the Dr. B.R. Ambedkar Institute and Rotary Cancer Hospital (DR BRAIRCH) at AIIMS The overall goal is to better characterize the important association of HIV and cancer in India and to identify risk factors and potential viral co-factors which may ultimately service as the basis for future therapeutic and prevention interventions for this important co-morbidity in HIV.

描述（由申请人提供）：印度在全球范围内拥有最大的艾滋病毒感染者人群之一，估计为240万人。恶性肿瘤是艾滋病毒感染的已知合并症，在世界许多地方正在成比例。印度艾滋病毒感染者中癌症的发病率和表现尚未得到很好的特征，并且尚不清楚可能患有癌症作为其首次表现为HIV感染的HIV感染的患者比例。该提案的目的是获取有关在印度北部的主要癌症治疗和转诊中心1 - 2年期间，在1 - 2年期间观察到的HIV患病率的信息。我们将类似地评估同一机构（例如乳房，宫颈和前列腺）向癌症筛查诊所出现的患者的HIV患病率。另一个目标是收集信息；艾滋病毒和癌症患者的癌症，癌症类型，阶段，治疗和治疗结果的信息，艾滋病毒和癌症危险因素的人口统计学，艾滋病毒和临床状况，以及有关HIV和癌症患者的发生率的信息。此外，我们将类似地评估出现癌症患者的各种癌症危险因素以及各种致癌病毒的普遍性（与同一机构的同一机构的同时对照HIV+个体相比，在本研究的时间内不发展癌症的同一机构。这将允许在各种癌症类型中评估艾滋病毒普遍性以及对短期癌症的癌症和癌症的疾病范围内的信息，并允许对癌症的癌症造成癌症和癌症的疾病。从这项研究中确定的癌症和艾滋病毒个体将入学 和标本/组织库，我们将帮助建立前瞻性的随访和标本收集，以获取有关癌症，HIV治疗和临床结果的数据，并为未来的研究提供了同类研究，包括流行病学，实验室和可能的临床试验。通过收集的肿瘤和血液标本建立艾滋病毒和癌症登记处，将为我们的印度调查员同事提供进一步研究的宝贵资源（还有未来的印度外部资金）。这项研究将涉及加州大学洛杉矶分校，新德里的全印度医学科学研究所（AIIMS）与B.R.博士之间的合作。 AIIMS的Ambedkar Institute and Rotary Cancer Hospital（Brairch博士）的总体目标是更好地描述印度的艾滋病毒和癌症的重要联系，并确定 危险因素和潜在的病毒共同因素最终可能作为对艾滋病毒中这种重要的同胞的未来治疗和预防干预措施的基础。