Effects of Sertraline on Brain Connectivity in Adolescents with OCD

舍曲林对强迫症青少年大脑连接的影响

基本信息

批准号：
8567352
负责人：
GAIL A. BERNSTEIN
金额：
$ 22.8万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-12 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8567352
关键词：
Address Adolescent Adult Age Anterior Anxiety Disorders Brain Brain imaging Child Childhood Cognitive Corpus striatum structure Data Development Diffusion Dimensions Disease Drops Failure Fiber Functional Magnetic Resonance Imaging Functional disorder Funding Goals Human Image Imaging Device Imaging Techniques Investigation Link Maps Measures Minnesota National Institute of Mental Health Neurobiology Obsession Obsessive-Compulsive Disorder Participant Patients Pattern Pharmaceutical Preparations Pharmacological Treatment Pilot Projects Research Resolution Rest Sampling Scanning Selective Serotonin Reuptake Inhibitor Sertraline Severities Signal Transduction Site Symptoms Thalamic structure Thinking United States National Institutes of Health Universities Youth base cingulate cortex data acquisition disorder control effective therapy frontal lobe interest neuroimaging neuromechanism public health relevance putamen response treatment response white matter

项目摘要

DESCRIPTION (provided by applicant): Obsessive-compulsive disorder (OCD) is a debilitating disorder that afflicts 1% to 3% of youth worldwide. Previous research suggests that dysfunction of the frontal-striatal-thalamic circuitry (FSTC) underlies OCD symptoms. Our pilot study demonstrates that 15 adolescents with OCD (mostly medicated) in comparison with 12 controls show significantly lower functional connectivity (associated with higher OCD severity) in multiple FSTC segments. To build on these findings, 25 medication-free adolescents with OCD (ages 12-17) and 25 matched healthy controls will be evaluated using resting-state functional magnetic resonance imaging (R-fMRI) ('functional connectivity") and high angular resolution diffusion imaging (HARDI) ("structural connectivity") using advanced data acquisition strategies that are being developed at the University of Minnesota for the NIH-funded Human Connectome Project. All OCD and control participants will undergo R-fMRI and HARDI scans at baseline and 12 weeks later. OCD participants will receive 12 weeks of sertraline, a selective serotonin reuptake inhibitor (SSRI), to treat OCD symptoms. This approach will allow us to examine sertraline effects on FSTC in adolescents with OCD. We hope to identify specific connections in the FSTC that normalize with SSRI treatment. We will also investigate the relations between functional and structural connectivity in each segment of FSTC and correlate OCD dimensions and functional connectivity measures.

描述（由申请人提供）：强迫症（OCD）是一种使人衰弱的疾病，损害了全球青年1％至3％。先前的研究表明，额 - 纹状体 - 丘脑回路（FSTC）的功能障碍是强迫症症状的基础。我们的试点研究表明，与12个对照相比，有15名OCD（主要是药用）的青少年在多个FSTC段中表明功能连接性明显较低（与OCD较高的严重性相关）。为了建立这些发现，将使用静息状态功能磁共振成像（R-FMRI）（'功能连接性）和高角度分辨率评估25名无OCD（12-17岁）和25种匹配健康对照的无药物的青少年（年龄在12-17岁）和匹配的健康对照组中在明尼苏达州大学NIH资助的人类连接项目中，使用高级数据采集策略的扩散成像（HARDI）（“结构连接”）。 12周后，OCD参与者将获得12周的塞特拉林，一种选择性的血清素再摄取抑制剂（SSRI），以治疗OCD症状。与SSRI处理的FSTC，我们还将研究FSTC每个段的功能和结构连通性之间的关系，并将OCD维度和功能连接度量相关联。