Effects of Sertraline on Brain Connectivity in Adolescents with OCD

舍曲林对强迫症青少年大脑连接的影响

基本信息

批准号：
8719178
负责人：
GAIL A. BERNSTEIN
金额：
$ 19万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-12 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8719178
关键词：
Address Adolescent Adult Age Anterior Anxiety Disorders Brain Brain imaging Child Childhood Cognitive Compulsive Hoarding Corpus striatum structure Data Development Diffusion Dimensions Disease Drops Failure Fiber Functional Magnetic Resonance Imaging Functional disorder Funding Goals Human Image Imaging Device Imaging Techniques Investigation Link Maps Measures Minnesota National Institute of Mental Health Neurobiology Obsession Obsessive-Compulsive Disorder Participant Patients Pattern Pharmaceutical Preparations Pharmacological Treatment Pilot Projects Research Resolution Rest Sampling Scanning Selective Serotonin Reuptake Inhibitor Sertraline Severities Signal Transduction Site Symptoms Thalamic structure Thinking United States National Institutes of Health Universities Youth base cingulate cortex data acquisition disorder control effective therapy frontal lobe interest neuroimaging neuromechanism public health relevance putamen response treatment response white matter

项目摘要

DESCRIPTION (provided by applicant): Obsessive-compulsive disorder (OCD) is a debilitating disorder that afflicts 1% to 3% of youth worldwide. Previous research suggests that dysfunction of the frontal-striatal-thalamic circuitry (FSTC) underlies OCD symptoms. Our pilot study demonstrates that 15 adolescents with OCD (mostly medicated) in comparison with 12 controls show significantly lower functional connectivity (associated with higher OCD severity) in multiple FSTC segments. To build on these findings, 25 medication-free adolescents with OCD (ages 12-17) and 25 matched healthy controls will be evaluated using resting-state functional magnetic resonance imaging (R-fMRI) ('functional connectivity") and high angular resolution diffusion imaging (HARDI) ("structural connectivity") using advanced data acquisition strategies that are being developed at the University of Minnesota for the NIH-funded Human Connectome Project. All OCD and control participants will undergo R-fMRI and HARDI scans at baseline and 12 weeks later. OCD participants will receive 12 weeks of sertraline, a selective serotonin reuptake inhibitor (SSRI), to treat OCD symptoms. This approach will allow us to examine sertraline effects on FSTC in adolescents with OCD. We hope to identify specific connections in the FSTC that normalize with SSRI treatment. We will also investigate the relations between functional and structural connectivity in each segment of FSTC and correlate OCD dimensions and functional connectivity measures.

描述（由申请人提供）：强迫症 (OCD) 是一种使人衰弱的疾病，困扰着全世界 1% 至 3% 的青少年。先前的研究表明，额叶-纹状体-丘脑回路（FSTC）功能障碍是强迫症症状的根源。我们的试点研究表明，与 12 名对照组相比，15 名患有强迫症的青少年（大部分是接受药物治疗的）在多个 FSTC 片段中表现出明显较低的功能连接（与较高的强迫症严重程度相关）。为了在这些发现的基础上，将使用静息态功能磁共振成像 (R-fMRI)（“功能连接”）和高角分辨率对 25 名未接受药物治疗的强迫症青少年（12-17 岁）和 25 名匹配的健康对照进行评估使用明尼苏达大学为 NIH 资助的人类连接组项目开发的先进数据采集策略进行扩散成像 (HARDI)（“结构连接”）。所有 OCD 和对照参与者都将接受 R-fMRI。基线和 12 周后进行 HARDI 扫描，强迫症参与者将接受 12 周的舍曲林（一种选择性血清素再摄取抑制剂 (SSRI)）治疗，以治疗强迫症症状。我们希望找出 FSTC 中与 SSRI 治疗正常化的具体联系，我们还将研究 FSTC 每个部分的功能和结构连接之间的关系，并与强迫症维度相关。和功能连接措施。