Effects of Sertraline on Brain Connectivity in Adolescents with OCD

舍曲林对强迫症青少年大脑连接的影响

• 批准号: 8719178
• 负责人: GAIL A. BERNSTEIN
• 金额: $ 19万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-12 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8719178
• 关键词: Address; Adolescent; Adult; Age; Anterior; Anxiety Disorders; Brain; Brain imaging; Child; Childhood; Cognitive; Compulsive Hoarding; Corpus striatum structure; Data; Development; Diffusion; Dimensions; Disease; Drops; Failure; Fiber; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Goals; Human; Image; Imaging Device; Imaging Techniques; Investigation; Link; Maps; Measures; Minnesota; National Institute of Mental Health; Neurobiology; Obsession; Obsessive-Compulsive Disorder; Participant; Patients; Pattern; Pharmaceutical Preparations; Pharmacological Treatment; Pilot Projects; Research; Resolution; Rest; Sampling; Scanning; Selective Serotonin Reuptake Inhibitor; Sertraline; Severities; Signal Transduction; Site; Symptoms; Thalamic structure; Thinking; United States National Institutes of Health; Universities; Youth; base; cingulate cortex; data acquisition; disorder control; effective therapy; frontal lobe; interest; neuroimaging; neuromechanism; public health relevance; putamen; response; treatment response; white matter

DESCRIPTION (provided by applicant): Obsessive-compulsive disorder (OCD) is a debilitating disorder that afflicts 1% to 3% of youth worldwide. Previous research suggests that dysfunction of the frontal-striatal-thalamic circuitry (FSTC) underlies OCD symptoms. Our pilot study demonstrates that 15 adolescents with OCD (mostly medicated) in comparison with 12 controls show significantly lower functional connectivity (associated with higher OCD severity) in multiple FSTC segments. To build on these findings, 25 medication-free adolescents with OCD (ages 12-17) and 25 matched healthy controls will be evaluated using resting-state functional magnetic resonance imaging (R-fMRI) ('functional connectivity") and high angular resolution diffusion imaging (HARDI) ("structural connectivity") using advanced data acquisition strategies that are being developed at the University of Minnesota for the NIH-funded Human Connectome Project. All OCD and control participants will undergo R-fMRI and HARDI scans at baseline and 12 weeks later. OCD participants will receive 12 weeks of sertraline, a selective serotonin reuptake inhibitor (SSRI), to treat OCD symptoms. This approach will allow us to examine sertraline effects on FSTC in adolescents with OCD. We hope to identify specific connections in the FSTC that normalize with SSRI treatment. We will also investigate the relations between functional and structural connectivity in each segment of FSTC and correlate OCD dimensions and functional connectivity measures.

描述（由申请人提供）：强迫症（OCD）是一种使人衰弱的疾病，损害了全球青年1％至3％。先前的研究表明，额 - 纹状体 - 丘脑回路（FSTC）的功能障碍是强迫症症状的基础。我们的试点研究表明，与12个对照相比，有15名OCD（主要是药用）的青少年在多个FSTC段中表明功能连接性明显较低（与OCD较高的严重性相关）。为了基于这些发现，将使用静止状态功能性磁共振成像（R-FMRI）（'功能连接性'）（'功能连接性'）和高角度分辨率分辨率扩散成像（HADII）（HADDI）（“结构性连接）（“结构性连接”策略，使用高级数据纳入Uncepta n n Cilesta n y countion n s nimenties nivectiation n n n n Cilesta，将使用静止状态功能性磁共振成像（R-FMRI）（'功能连接）（“功能连接”）评估25种无药物（12-17岁）和25个匹配的健康对照的青少年使用高级数据的策略来评估。项目。我们还将研究FSTC每个段的功能和结构连接性之间的关系，并将OCD维度与功能连接度量相关联。