Inflammation and Fibrosis of the Vocal Folds

声带炎症和纤维化

• 批准号: 8209045
• 负责人: Ryan Comfort Branski
• 金额: $ 16.36万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-09 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8209045
• 关键词: Address; Agonist; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Autocrine Communication; Beds; Bilateral; Biochemical Process; Cell Line; Cells; Cicatrix; Complex; Coxibs; Cyclic AMP Receptors; Data; Dinoprostone; Dose; Dysphonia; Fetus; Fibroblasts; Fibrosis; Healed; Human; Inflammation; Inflammatory; Inflammatory Response; Injury; Interleukins; Investigation; Laboratories; Lamina Propria; Larynx; Lesion; Literature; Measures; Mediating; Modeling; Molecular; Morbidity - disease rate; Nature; Nuclear Translocation; Outcome; Paracrine Communication; Pathway interactions; Patients; Phase; Phenotype; Principal Investigator; Production; Rattus; Reporting; Role; Severities; Signal Pathway; Signal Transduction; Structure; Techniques; Time; Tissues; Transcriptional Regulation; Transforming Growth Factors; Up-Regulation; Wound Healing; autocrine; base; clinical application; cyclooxygenase 2; cytokine; healing; injured; injury and repair; insight; novel; patient population; programs; public health relevance; regenerative; repaired; response; vocal cord; wound

项目成果

Cyclooxygenase-2 signaling in vocal fold fibroblasts.

声带成纤维细胞中的环加氧酶 2 信号传导。

• 发表时间: 2010-09
• 作者: Branski, Ryan C;Zhou, Hang;Sandulache, Vlad C;Chen, Jie;Felsen, Diane;Kraus, Dennis H
• 通讯作者: Kraus, Dennis H

Prostaglandin (PG)E2 exhibits antifibrotic activity in vocal fold fibroblasts.

前列腺素 (PG)E2 在声带成纤维细胞中表现出抗纤维化活性。

• 发表时间: 2011-06
• 作者: Zhou, Hang;Felsen, Diane;Sandulache, Vlad C;Amin, Milan R;Kraus, Dennis H;Branski, Ryan C
• 通讯作者: Branski, Ryan C

Glucocorticoids regulate extracellular matrix metabolism in human vocal fold fibroblasts.

糖皮质激素调节人声带成纤维细胞的细胞外基质代谢。

• 发表时间: 2011-09
• 作者: Zhou, Hang;Sivasankar, Mahalakshmi;Kraus, Dennis H;Sandulache, Vlad C;Amin, Milan;Branski, Ryan C
• 通讯作者: Branski, Ryan C

The effects of cigarette smoke condensate on vocal fold transepithelial resistance and inflammatory signaling in vocal fold fibroblasts.

香烟烟雾冷凝物对声带成纤维细胞声带跨上皮阻力和炎症信号的影响。

• 发表时间: 2011-03
• 作者: Branski, Ryan C.;Zhou, Hang;Kraus, Dennis H.;Sivasankar, Mahalakshmi
• 通讯作者: Sivasankar, Mahalakshmi