Midcareer Investigator Award in Patient-Oriented Research for Dr. Ryan Branski

Ryan Branski 博士荣获以患者为导向的研究中的职业生涯中期研究员奖

基本信息

批准号：
10363720
负责人：
Ryan Comfort Branski
金额：
$ 16.6万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10363720
关键词：
Acoustics Acute Address Aerodigestive Tract Affect Aftercare Age Anatomy Auditory Award Behavioral Bolus Infusion Botox Botulinum Toxins Classification Clinical Clinical Sciences Clinical assessments Communication Communication impairment Complex Data Deglutition Deglutition Disorders Discipline Disease Dystonia Essential Tremor Faculty Family Foundations Functional disorder Funding Goals Health Human Injections Institutes Laboratories Laboratory Research Limb Tremors Limb structure Location Measures Medical Mentors Mentorship Midcareer Investigator Award in Patient-Oriented Research Mission Movement Disorders National Institute on Deafness and Other Communication Disorders Neurologic Nomenclature Operative Surgical Procedures Oropharyngeal Outcome Parkinsonian Disorders Patient Care Patient Self-Report Patients Persons Pharmacological Treatment Pharmacology Phenotype Population Positioning Attribute Postdoctoral Fellow Primidone Process Propranolol Publications Recording of previous events Refractory Research Research Personnel Severities Standardization Structure Students Systemic Therapy Therapeutic Training Translational Research Tremor Update Upper Extremity Variant Voice Work base career career development clinical phenotype disability experience feeding improved insight kinematics medical schools multidisciplinary patient oriented research patient population programs translational impact treatment effect

项目摘要

PROJECT SUMMARY/ABSTRACT Tremor affects ~1% of the global population or nearly 80 million people. In spite of this staggering figure, both nomenclature and treatment approaches are inconsistent. Many patients present with tremor affecting the voice, either in isolation or in combination with tremor of the limbs. Isolated vocal tremor was historically considered a clinical variant of essential tremor (ET). Recently updated classification criteria, however, exclude isolated voice tremor from ET classification. This controversy provides an ideal platform for meaningful patient- oriented research with the potential to substantively address issues related to communication-related disability. In addition, this K24 midcareer award will allow me to enhance the quantity and quality of mentoring I provide to students, residents, fellows, and junior faculty. My research focus for this award will be on understanding differences in the clinical phenotypes between these two patient populations and the impact of voice tremor on structures of the upper aerodigestive tract and deglutition. In addition, foundational efficacy data regarding pharmacological therapy for patients with voice tremor will be collected. Both Career Goals and Research Aims, consistent with the mission of the National Institute on Deafness and Other Communication Disorders, are proposed for this K24 midcareer award. With regard to career development and mentorship, the following Career Goals are proposed: Career Goal 1. To evaluate the quality of my mentoring and implement a plan for improvement through a formalized training plan Career Goal 2. To mentor junior students, post-doctoral scholars, residents, fellows, and faculty in translational science to enhance patient care through scientific discovery In addition, a multi-disciplinary team has been assembled to address the following Research Aims: Aim 1. To characterize overlapping and/or distinguishing clinical phenotypes of patients with ETVT and iVT. Aim 2. To correlate VT severity with altered deglutition in ETVT and iVT. Aim 3 (Exploratory). To compare systemic and locally administered pharmacological treatment effects for ETVT and iVT.

项目概要/摘要震颤影响着全球约 1% 的人口，即近 8000 万人。尽管这个数字令人震惊，术语和治疗方法不一致。许多患者出现震颤，影响声音，无论是单独的还是与四肢颤抖相结合的。历史上孤立性声带震颤被认为是原发性震颤（ET）的临床变异。然而，最近更新的分类标准不包括 ET 分类中孤立的声音颤抖。这一争议为有意义的患者提供了一个理想的平台—— 有潜力实质性解决与沟通相关的残疾问题的定向研究。此外，这个 K24 职业中期奖将使我能够提高我提供的指导的数量和质量面向学生、住院医生、研究员和初级教师。我对这个奖项的研究重点是理解这两个患者群体之间临床表型的差异以及声音震颤对上呼吸消化道和吞咽的结构。此外，有关的基本功效数据将收集对声音震颤患者的药物治疗。职业目标和研究目标，与国家耳聋研究所的使命一致其他沟通障碍，被提议用于此 K24 职业中期奖。关于职业生涯发展和指导，提出以下职业目标：职业目标 1. 评估我的指导质量并通过以下方式实施改进计划正式培训计划职业目标 2. 指导大三学生、博士后学者、住院医师、研究员和教师进行转化通过科学发现加强患者护理的科学此外，还组建了一个多学科团队来实现以下研究目标：目标 1. 描述 ETVT 和 iVT 患者的重叠和/或区别临床表型。目标 2. 将 VT 严重程度与 ETVT 和 iVT 吞咽改变相关联。目标 3（探索性）。比较 ETVT 的全身和局部药物治疗效果和 iVT。