In Vivo Ultrasound Imaging System (VEVO 2100, VisualSonics)

体内超声成像系统（VEVO 2100，VisualSonics）

• 批准号: 8448036
• 负责人: Nipavan Chiamvimonvat
• 金额: $ 39.71万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8448036
• 关键词: Adult; Agriculture; Anatomy; Animal Model; Biological; Biological Sciences; Blood Vessels; Canada; Cardiovascular Diseases; Cardiovascular system; Disease; Disease model; Ecology; Embryo; Engineering; Faculty; Fostering; Funding; Genes; Goals; Image; Injection of therapeutic agent; Kidney; Lung; Lung diseases; Malignant Neoplasms; Medicine; MicroRNAs; Modeling; Neuraxis; Organ; Physiological; Physiology; Reagent; Research; Research Personnel; Research Project Grants; Resolution; Schools; Secure; Small Interfering RNA; Staging; Stem cells; System; Technology; Time; Time Study; Translational Research; Ultrasonography; United States National Institutes of Health; Vascular Diseases; Veterinary Medicine; Visual; career; college; design; human disease; in vivo; knowledge translation; medical schools; member; multidisciplinary; nervous system disorder; particle; preclinical study; systems research

DESCRIPTION (provided by applicant): The goal of this proposal is to secure funding for an in vivo ultrasound imaging system for small animal models (VEVO 2100, Visual Sonics, Toronto, Canada). This is a high-resolution in vivo ultrasound micro- imaging system designed specifically for non-invasive real-time studies of integrated anatomy and physiology in small animal models. The system offers spatial resolutions from 100 ¿m to 30 ¿m with depths from 36 mm down to 12 mm respectively, which represents the highest resolution available today. Moreover, the real-time imaging system allows for ultrasound-guided injections for delivery of biological reagents (micro particles, genes, siRNA, microRNA, and stem cells) to different organs in small animal models. This technology is not currently available at UC Davis. The proposed system will serve a large group of NIH-funded investigators. A unique feature of our research team is the diversity of its faculty. Our team members are at various stages of their careers and are members of multiple departments from five different schools/colleges (School of Medicine, School of Veterinary Medicine, School of Engineering, College of Agricultural and Environmental Sciences, and College of Biological Sciences). This group of investigators is involved in several multidisciplinary collaborative projects that include cardiovascular, vascular, pulmonary, renal, and central nervous systems research. The uses of small animal models, including genetically targeted models, have paved the way for major advances in Medicine during recent years. Indeed, these small animal models are critical for the preclinical studies of diverse classes of diseases including cardiovascular and vascular diseases, pulmonary diseases, cancers, and neurological diseases. The ability to directly quantify the anatomical and physiologic information at a high resolution from embryos to adulthood as well as the use of ultrasound-guided delivery of biological reagents will greatly advance our knowledge and translation of these models to the treatment of human diseases. This proposal will enable the application of non-invasive in vivo high-resolution assessment of disease models that will foster further collaborative translational research projects.

描述（由适用提供）：该提案的目的是为小动物模型的体内超声成像系统获得资金（VEVO 2100，Visual Sonics，加拿大多伦多）。这是一个高分辨率超声微型成像系统，专门针对小动物模型中综合解剖学和生理学的非侵入性实时研究。该系统提供的空间分辨率从100€至30€m，深度分别从36毫米向下至12毫米，这代表了当今可用的最高分辨率。此外，实时成像系统允许对小动物模型中不同器官的生物试剂（微粒，基因，siRNA，microRNA和干细胞）的生物试剂（微粒，基因，siRNA，microRNA和干细胞）的超声注射。加州大学戴维斯分校目前尚未提供这项技术。拟议的系统将为一大批由NIH资助的调查人员提供服务。我们的研究团队的一个独特功能是其教职员工的多样性。我们的团队成员处于职业生涯的各个阶段，并且是来自五个不同学校/学院的多个部门的成员（医学院，兽医学院，工程学院，农业与环境科学学院，生物科学学院）。这组研究人员参与了几个多学科合作项目，包括心血管，血管， 肺，肾脏和中枢神经系统研究。近年来，小动物模型（包括一般针对性的模型）的使用已为医学上的重大进展铺平了道路。实际上，这些小动物模型对于临床前研究的临床前研究至关重要，包括心血管疾病，肺部疾病，癌症和神经系统疾病，包括心血管和血管疾病。从胚胎到成年的高分辨率以及使用超声引导的生物学剂的使用，可以直接量化解剖学和生理信息的能力，这将大大提高我们将这些模型的知识和转化为治疗人类疾病的治疗。该提案将使非侵入性在体内高分辨率评估疾病模型的应用，这将促进进一步的协作转化研究项目。