Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered

口服药效调节的生物物理机制研究

基本信息

批准号：
8564198
负责人：
NICHOLAS A PEPPAS
金额：
$ 22.24万
依托单位：
METHODIST HOSPITAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-28 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8564198
关键词：
Academy Animal Model Animals Biocompatible Materials Bioinformatics Biomedical Engineering Blood Circulation Calcitonin Cell Proliferation Cells Characteristics Chemicals Chitosan Collaborations Colorectal Cancer Colorectal Neoplasms Diffusion Disease Drug Delivery Systems Drug Kinetics Electrical Resistance Engineering Enhancers Environment Epithelial Epithelial Cells Evaluation Face Gastrointestinal tract structure Growth In Vitro Institute of Medicine (U.S.)Insulin Intestines Intraocular lens implant device Kinetics Label Legal patent Measurement Measures Medical Device Membrane Modeling Oral Oral Administration Osteoporosis Pharmaceutical Preparations Pharmacy (field)Pharmacy facility Physics Plasma Postmenopause Process Property Reaction Research Signal Transduction Staging Stimulus Structure System Testing Tight Junctions Toxic effect Tumor Tissue United States National Academy of Sciences Woman absorption bile salts carrier mediated transport chemical property chemotherapeutic agent design diabetic patient gastrointestinal gastrointestinal epithelium hydrophilicity in vivo intestinal epithelium ionization meetings member metastatic colorectal molecular recognition monolayer nanobiotechnology nanodevice nanoparticle pH gradient particle prevent professor research study response restoration tool transcytosis tumor type I diabetic vocal cord

项目摘要

Project 4 is dealing with various physical barriers that chemotherapeutical agent administered orally meets on its way to be systemically absorbed and to reach the target tumor tissue. These barriers include for example: changes in pH across the gastrointestinal (Gl) tract, enzymatic degradation, epithelial transport through different mechanisms. To study and tackle these barriers we will use our engineered polymeric carriers. This project is led by Dr. Nicholas Peppas using animal models of Dr. Fidler as described in Project 1. Dr. Nicholas Peppas is a Professor in the Departments of Chemical, Biomedical Engineering and Pharmaceutics and Fletcher S. Pratt Chair of Engineering at UTA. Dr. Peppas is a world leader in the fields of bionanotechnology and molecular recognition processes, nanodevices for controlled drug delivery, and intelligent biomaterials. Among other medical devices, he has developed, patented and/or commercialized intraocular lenses, materials for vocal cord restoration, nanodelivery systems for oral administration of insulin to type I diabetic patients, and systems for oral delivery of calcitonin for treatment of postmenopausal women suffering from osteoporosis. Dr. Peppas is a member of the National Academy of Engineering, a member of the Institute of Medicine of the National Academy of Sciences and the French Academy of Pharmacy.

项目4正在解决口服化疗药物在被全身吸收并到达目标肿瘤组织过程中遇到的各种物理障碍。这些障碍包括例如：胃肠道(GI)的pH变化、酶促降解、通过不同机制的上皮转运。为了研究和解决这些障碍，我们将使用我们的工程聚合物载体。该项目由 Nicholas Peppas 博士领导，使用项目 1 中所述的 Fidler 博士的动物模型。Nicholas Peppas 博士是 UTA 化学、生物医学工程和制药系的教授，也是 Fletcher S. Pratt 工程系主任。 Peppas 博士是生物纳米技术和分子识别过程、受控药物输送纳米设备以及智能生物材料领域的世界领先者。除其他医疗设备外，他还开发了人工晶状体、声带修复材料、用于向 I 型糖尿病患者口服胰岛素的纳米递送系统、以及用于治疗患有以下疾病的绝经后妇女的降钙素口服递送系统，并获得专利和/或商业化：骨质疏松症。佩帕斯博士是美国国家工程院院士、美国国家科学院医学研究所和法国药学院院士。