Brain Networks Modulating Affect Self-Regulation in Pediatric Mania

大脑网络调节影响小儿躁狂症的自我调节

基本信息

批准号：
8429362
负责人：
Mani N Pavuluri
金额：
$ 4.62万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-02-16 至 2013-08-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8429362
关键词：
14 year old Address Affect Affective Anisotropy Anterior Area Automobile Driving Award Behavioral Paradigm Biological Markers Biological Neural Networks Bipolar Disorder Brain Brain region Child Child Psychiatry Childhood Clinical Clinical Research Clip Cognitive Commit Consultations Data Development Diffusion Dimensions Disease Early Intervention Early identification Educational process of instructing Emotional Event Failure Fiber Film Functional Magnetic Resonance Imaging Functional disorder Funding Future Goals Grant Gray unit of radiation dose Hand Healthcare Home environment Impaired cognition Inferior Informal Social Control Internal Capsule Intervention Knowledge Leadership Learning Link Maintenance Manic Maps Mentors Methodology Methods Mid-Career Clinical Scientist Award (K24)Multimodal Imaging National Institute of Mental Health Neurobiology Parietal Patient Care Patients Phenotype Physicians Population Postdoctoral Fellow Preventive Process Recruitment Activity Regulation Relative (related person)Reporting Research Research Methodology Research Personnel Sampling Sampling Studies School-Age Population Schools Science Scientist Stimulus Techniques Technology Time Training Translational Research Treatment outcome Underachievement United States National Institutes of Health Work Youth affective neuroscience age group base brain research career childhood bipolar disorder clinical application cognitive control comparison group experience falls graduate student hemodynamics imaging modality indexing innovation middle school next generation patient oriented patient oriented research programs prototype research study response skills suicidal behavior white matter

项目摘要

DESCRIPTION (provided by applicant): Dr. Pavuluri has spent the majority of the last 10 years in brain research and intervention in bipolar disorder, mentoring researchers, caring for patients and providing consultation to physicians and health care leaders in Child Psychiatry. She is committed to continuing her work in the area of patient-oriented research, mentoring, leadership and patient care for the remainder of her academic career. Dr. Pavuluri is specifically committed to addressing the critical shortage of physician scientists conducting research in affective neuroscience in child psychiatry. Goal of K24 application: The goal of this application is to provide the PI with 30% time to mentor junior patient-oriented investigators and expand her research program into defining a dimensional approach to brain function through functional network analyses and fusion analyses of functional and white matter networks in PBD. If the K24 is awarded in June 2011, she would be funded 70% time by three NIMH funded grants (RO1, RO1, and K24). She will be completing one of her NIMH grants in the fall of 2011 (NIMH 1RC1MH088462 -01). Proposed mentoring activities: The K24 award will allow her to expand her research mentoring activities in affective neuroscience by including new post-doctoral fellows and graduate students. It would allow her to spend more time on the methods required to advance science through the proposed proof of concept study of affect self-regulation that combines the neuroscientific and technical skills that will definitively advance the methodological sophistication also required for her recently funded RO1 grants. Towards this goal, she plans to develop 1-2 new graduate courses on how to conduct multimodal imaging research in developmental affective neuroscience in the clinical population with a focus on research methodology and analytic strategies. Significance: The proposed K24 addresses the current NIH Roadmap Initiatives that seek focus on clinical application, neurobiology, development, dimensional focus, training new physician scientists, and driving the capacity to conduct translational research.

描述（由申请人提供）：Pavuluri 博士在过去 10 年的大部分时间里从事双相情感障碍的脑研究和干预、指导研究人员、照顾患者以及为儿童精神病学领域的医生和医疗保健领导者提供咨询。她致力于在余下的学术生涯中继续从事以患者为中心的研究、指导、领导和患者护理领域的工作。 Pavuluri 博士特别致力于解决从事儿童精神病学情感神经科学研究的医师科学家的严重短缺问题。 K24 应用程序的目标：该应用程序的目标是为 PI 提供 30% 的时间来指导以患者为导向的初级研究人员，并将其研究计划扩展为通过功能网络分析以及功能和白细胞的融合分析来定义大脑功能的维度方法。 PBD 中的物质网络。如果 K24 于 2011 年 6 月获得，她的 70% 时间将由 NIMH 资助的三项拨款（RO1、RO1 和 K24）获得资助。她将于 2011 年秋季完成其中一项 NIMH 拨款（NIMH 1RC1MH088462 -01）。拟议的指导活动：K24 奖将使她能够通过吸收新的博士后研究员和研究生来扩大她在情感神经科学领域的研究指导活动。这将使她能够花更多的时间在通过拟议的情感自我调节概念验证研究来推进科学发展所需的方法上，该研究结合了神经科学和技术技能，最终将提高她最近资助的 RO1 拨款所需的方法论复杂性。为了实现这一目标，她计划开发 1-2 个新的研究生课程，介绍如何在临床人群中进行发育情感神经科学的多模态成像研究，重点是研究方法和分析策略。意义：拟议的 K24 解决了当前 NIH 路线图倡议，该倡议寻求关注临床应用、神经生物学、发展、维度焦点、培训新的医师科学家以及提高进行转化研究的能力。