Spatial and reward coding in the primate amygdala

灵长类杏仁核的空间和奖励编码

• 批准号: 8544200
• 负责人: ELLEN PECK
• 金额: $ 4.72万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8544200
• 关键词: Address; Affect; Amygdaloid structure; Area; Attention; Autistic Disorder; Behavioral; Brain; Cell Nucleus; Code; Cognitive; Cues; Data; Disease; Emotional; Functional disorder; Future; Goals; Grant; Laboratories; Left; Limbic System; Literature; Location; Monkeys; Nature; Neurons; Outcome; Patients; Play; Primates; Process; Property; Psychological reinforcement; Research; Research Personnel; Rewards; Role; Schizophrenia; Signal Transduction; Stimulus; Training; Universities; Ursidae Family; Visual; Work; conditioning; emotional reaction; fighting; neurophysiology; neuropsychiatry; research study; response; visual stimulus

DESCRIPTION (provided by applicant): The amygdala is a cluster of nuclei in the brain that is often associated with the "fight-or-flight" response and emotional reactions. It is part of the limbic system, and is known to be involved in assigning value, both positive and negative, to stimuli; additionally, it has more recently been implicated in attention. Much of the work regarding the role of the amygdala in assigning motivational significance to stimuli was completed in the laboratory of Daniel Salzman at Columbia University. Recent experiments in the lab have used tasks in which multiple motivationally significant cues are shown simultaneously, with one cue being associated with a more valuable outcome than the other, in order to bias spatial attention to the location of the more valuable cue. Although it is not surprising that behavioral data show that atention is biased to the more valuable cue, neurophysiological data recorded from the amygdala during this task also show that not only does the amygdala encode motivational significance, but it also encodes a spatial signal. These data were unexpected, as the amygdala has not been thought of as a spatial area, and they raise fundamental questions about the role of amygdala neurons in spatial processing. This proposal seks to address these questions, such as under what circumstances amygdala neurons become spatially selective!

描述（由申请人提供）：杏仁核是大脑中的一个核簇，通常与“战斗或飞行”的反应和情感反应有关。它是边缘系统的一部分，众所周知，它参与了为刺激分配正值和负面的价值。此外，它最近涉及注意力。哥伦比亚大学的丹尼尔·萨尔茨曼（Daniel Salzman）实验室完成了有关杏仁核在为刺激分配动机意义方面的作用的许多工作。实验室中的最新实验使用了任务，在这些任务中，同时显示了多个具有动力意义的线索，一种提示与另一个提示相比，与另一个提示相关，以使空间的关注偏向更有价值的提示的位置。尽管行为数据表明，在这项任务中，从杏仁核记录的神经生理数据偏向于更有价值的提示也就不足为奇了，但它不仅表明杏仁核编码动机意义，而且还编码了空间信号。这些数据是出乎意料的，因为杏仁核并未被认为是空间区域，并且它们提出了有关杏仁核神经元在空间处理中的作用的基本问题。该提案旨在解决这些问题，例如在什么情况下，杏仁核神经元在空间上具有选择性！