MIND Institute Intellectual and Developmental Disabilities Research Center

MIND 研究所智力与发育障碍研究中心

基本信息

批准号：
8650425
负责人：
LEONARD J. ABBEDUTO
金额：
$ 130万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-24 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8650425
关键词：
22q11.2 Address Animals Area Attention deficit hyperactivity disorder Basic Science Behavior Behavior Therapy Behavioral Bioinformatics Biological Biological Assay Biological Markers Biology Biometry Brain California Child Child Behavior Chromosomes Clinical Clinical Sciences Clinical Trials Combined Modality Therapy Complex Data Diagnostic Discipline Down Syndrome Educational process of instructing Environment Environmental Pollution Exposure to FMR1 Family Fostering Fragile X Syndrome Funding Genes Genetic Predisposition to Disease Heterogeneity Human Immune System Diseases Individual Individual Differences Institutes Intervention Investigation Language Leadership Lovastatin MEKs Measures Medical Mental Retardation and Developmental Disabilities Research Centers Molecular and Cellular Biology National Institute of Child Health and Human Development Nature Neurodevelopmental Disorder Outcome Outcome Measure Parents Participant Pathway interactions Pharmaceutical Preparations Pharmacological Treatment Phenotype Placebos Preclinical Drug Evaluation Prevention Prevention strategy Randomized Randomized Controlled Trials Research Research Design Research Infrastructure Research Project Grants Resources Risk Rodent Rodent Model Role Safety Services Signal Pathway Source Symptoms Syndrome Teratogens Translational Research Treatment Efficacy United States National Institutes of Health Universities Variant autism spectrum disorder biobehavior cost effective design disorder risk endophenotype gene interaction immune function innovation insight intellectual and developmental disability interdisciplinary collaboration molecular imaging mutant neurobehavioral novel prevent programs relating to nervous system response social telehealth

项目摘要

DESCRIPTION (provided by applicant): The present application seeks funding to establish an Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, which will be fully integrated into, and benefit from, the existing resources of the UC Davis MIND Institute and its campus partners. The MIND Institute is an integrated program that is internationally recognized for ground-breaking studies of autism, fragile X syndrome, and other IDD conditions. The proposed IDDRC includes three components. First, we propose a research component that addresses the focus area of Multi-Modal Treatment Approaches. This component includes a clinical trial targeting children with fragile X syndrome that combines a drug (lovastatin) with a parent-implemented intervention. Novel outcome measures focusing on language and challenging behavior will evaluate efficacy. The clinical trial will be accompanied by studies focused on FMRI-related signaling pathways so as to illuminate the mechanisms by which treatment achieves its effects and to identify biomarkers that indicate treatment efficacy and individual differences in response to treatment. Second, we propose for inclusion 56 IDD-related projects funded by NIH and other federal and private sources. Ten of the projects are funded by NICHD. These projects address three scientific themes: Integrated Biobehavioral Characterization of IDD, Environmental Contributions to IDD, and Treatments for IDD. Third, we propose core components to facilitate interdisciplinary, translational research in IDD. The cores include an Administrative Core and a Clinical Translational Core, with the latter focused on recruitment and diagnostic characterization of human participants. The remaining cores will provide assays of immune function, cellular and molecular biology and imaging, and environmental contaminants (Biological Analysis Core); measures of complex human behavior, particularly for establishing endophenotypes (Neurobehavioral Analysis Core); assays of rodent behavior for evaluating mutant rodent models and supporting preclinical evaluations of drug safety and efficacy (Rodent Behavior Core); and the management and analysis of complex multidimensional data derived from human and animal studies (Biostatistics, Bioinformatics, and Research Design).

描述（由申请人提供）：本申请寻求资金来建立加利福尼亚大学的智力和发育障碍研究中心（IDDRC），该研究中心将完全融入并从UC的现有资源中受益戴维斯·思维学院及其校园合作伙伴。 Mind Institute是一项综合计划，在自闭症，脆弱X综合征和其他IDD条件的开创性研究中被国际认可。提出的IDDRC包括三个组件。首先，我们提出了一个研究组件，以解决多模式治疗方法的重点领域。该成分包括针对患有脆弱X综合征的儿童的临床试验，该试验将药物（lovastatin）与父母实施干预结合在一起。专注于语言和挑战行为的新颖结果措施将评估功效。临床试验将伴随着针对fMRI相关的信号通路的研究，以阐明治疗实现其作用的机制，并鉴定出表明治疗功效和对治疗响应的个体差异的生物标志物。其次，我们提议包含56个由NIH和其他联邦和私人资源资助的IDD相关项目。十个项目由NICHD资助。这些项目涉及三个科学主题：IDD的综合生物行为特征，对IDD的环境贡献以及IDD治疗的综合表征。第三，我们提出核心组成部分，以促进IDD中的跨学科，翻译研究。核心包括行政核心和临床翻译核心，后者的重点是人类参与者的招聘和诊断表征。其余核心将提供免疫功能，细胞和分子生物学和成像以及环境污染物（生物分析核心）的测定；复杂人类行为的衡量标准，特别是用于建立内型型（神经行为分析核心）；用于评估突变啮齿动物模型的啮齿动物行为的测定和支持药物安全和功效的临床前评估（啮齿动物行为核心）；以及从人类和动物研究（生物统计学，生物信息学和研究设计）得出的复杂多维数据的管理和分析。