MIND Institute Intellectual and Developmental Disabilities Research Center

MIND 研究所智力与发育障碍研究中心

• 批准号: 10430105
• 负责人: LEONARD J. ABBEDUTO
• 金额: $ 125.2万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10430105
• 关键词: 22q; Address; Affect; Angelman Syndrome; Antibodies; Area; Attention deficit hyperactivity disorder; Autoantibodies; Basic Science; Behavior; Behavior Therapy; Behavioral; Bioinformatics; Biological; Biological Assay; Biological Markers; Biological Models; Biological Response Modifier Therapy; Biometry; California; Child; Chromosomes; Clinical; Clinical Data; Clinical Sciences; Communication; Communities; Complex; Data; Development; DiGeorge Syndrome; Diagnosis; Discipline; Down Syndrome; Education; Ensure; Environmental Exposure; Epigenetic Process; Exposure to; FMR1; Faculty; Family; Fostering; Fragile X Syndrome; Funding; Genetic; Genetic Predisposition to Disease; Heterogeneity; Home; Human; Immune System Diseases; Individual; Institutes; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; International; Intervention; Leadership; Measures; Medical center; Modeling; Molecular Analysis; Mothers; Mus; National Institute of Child Health and Human Development; Nature; Neuroimmune; Outcome; Outcome Measure; Participant; Pathway interactions; Peer Review; Persons; Phenotype; Policy Maker; Preclinical Drug Evaluation; Pregnancy; Prevention approach; Process; Rattus; Reduce health disparities; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Rodent; Rodent Model; Role; Route; Sampling; Schools; Science; Services; Site; Source; Statistical Data Interpretation; Systems Analysis; Technology; Teratogens; Testing; Training; Translational Research; Treatment Efficacy; United States National Institutes of Health; Universities; associated symptom; autism spectrum disorder; biobehavior; biomarker development; brain abnormalities; catalyst; cellular imaging; clinical care; cohort; college; cost effective; digital; disorder risk; drug efficacy; electronic data; evidence base; gene environment interaction; health care disparity; high risk; immune function; improved; innovation; insight; interdisciplinary collaboration; medication safety; molecular imaging; multidimensional data; mutant; neurodevelopment; operation; outreach; prevent; programs; recruit; social disparities

PROJECT SUMMARY – OVERALL The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The MIND Institute IDDRC will address four specific aims. Aim 1 is to conduct interdisciplinary translational research that yields insights into the nature, causes, and consequences of IDD and leads to innovative evidence-based approaches to prevention and treatment. To this end, we propose 81 externally funded projects that reflect the themes of Integrated Biobehavioral Characterization of IDD, Genetic and Environmental Contributions to IDD, and Treatment of IDD. These projects are led by 43 investigators from 16 academic departments and 5 schools/colleges. 68 projects are funded by the NIH, including 16 by NICHD. Aim 2 is to accelerate the pace of interdisciplinary translational research via the operation of cost-effective, innovative, and widely used scientific cores. In addition to an Administrative Core, we propose four scientific cores. The Clinical Translational Core will facilitate recruitment of diverse samples of human participants, provide specialized clinical expertise to diagnose and characterize participants, support complex phenotyping, collect and store biospecimens, and integrate digital technologies into treatment studies. The Biological and Molecular Analysis Core will provide access to expertise and technologies in the areas of immune function, cellular and molecular imaging, epigenetics, and environmental exposures as they relate to neural development. The Rodent Behavior Core will provide assays of mouse and rat behavior, guidance in the development of mutant rodent models, and support for preclinical evaluations of drug safety and efficacy. The Biostatistics, Bioinformatics, and Research Design Core will provide support for study design, creation of electronic data capture and management systems, and statistical analysis of complex multidimensional datasets. Aim 3 is to improve the lives of people with IDD and reduce health and social disparities in care by developing a robust plan for disseminating and implementing scientific discoveries. The plan will involve multiple paths of communication to target professionals and policy makers, reach diverse communities, while being informed by the perspectives of people with IDD and their families. Aim 4 is to conduct a signature research project that examines the heterogeneity of outcomes and mechanisms underlying those outcomes in maternal autoantibody related (MAR) autism spectrum disorder (ASD), which may account for as much as 20% of ASD cases. The project will make use of existing human clinical data to inform the creation of rat model systems to test hypotheses about causal mechanisms. The signature project addresses three RFA themes: Preventing and mitigating the impact of exposures that can cause IDD, Outcome measures or biomarkers for interventions or treatments, and Development of biomarkers or assessment measures in more than one IDD condition.

项目摘要 - 总体 本申请寻求资金来继续思维学院的知识和发展 加州大学戴维斯分校的残疾研究中心（IDDRC）。 IDDRC于2013年启动 并且是网络中14个IDDRC中的最新一个。 Mind Institute IDDRC将解决四个具体目标。 目的1是进行跨学科的翻译研究，以产生对性质，原因和 IDD的后果并导致创新的基于证据的预防和治疗方法。对此 最后，我们提出了81个由外部资助的项目，这些项目反映了综合生物行为的主题 IDD的表征，对IDD的遗传和环境贡献以及IDD的治疗。这些项目 由来自16个学术部门和5所学校/学院的43位调查人员领导。 68个项目由 NIH，包括NICHD的16。目标2是通过 具有成本效益，创新和广泛使用的科学核心的操作。除了管理核心，我们 提案四个科学核心。临床翻译核心将有助于招募潜水员样本 人类参与者，提供专业的临床专业知识来诊断和表征参与者，支持 复杂的表型，收集和储存生物测量，并将数字技术集成到治疗研究中。 生物学和分子分析核心将在该领域提供专业知识和技术的访问 免疫功能，细胞和分子成像，表观遗传学和环境暴露与与之相关的环境暴露 神经发展。啮齿动物行为核心将提供小鼠和大鼠行为的暗示，指导 开发突变啮齿动物模型，并支持对药物安全和效率的临床前评估。这 生物统计学，生物信息学和研究设计核心将为研究设计提供支持 电子数据捕获和管理系统，以及复杂多维数据集的统计分析。 目标3是通过发展来改善IDD患者的生活，并通过发展来减少健康和社会差异 一个强大的计划，用于传播和实施科学发现。该计划将涉及多个路径 与目标专业人士和政策制定者的沟通，接触潜水员社区，同时被告知 IDD及其家人的人的观点。 AIM 4是进行一个签名研究项目， 检查孕产妇自身抗体的结果和机制的异质性和机制的异质性 相关（MAR）自闭症谱系障碍（ASD），可能占ASD病例的20％。这 项目将利用现有的人类临床数据来告知创建大鼠模型系统以测试 关于因果机制的假设。签名项目涉及三个RFA主题：预防和 减轻可能导致IDD，结果指标或生物标志物的暴露影响，或 在多个IDD条件下的生物标志物或评估措施的治疗和开发。