A Self-Assembling Gel with Antimicrobial and Antioxidant Properties for the Treat

具有抗菌和抗氧化特性的自组装凝胶，用于治疗

基本信息

批准号：
8597978
负责人：
DAVID J VACHON
金额：
$ 34.92万
依托单位：
NOVION TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-20 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8597978
关键词：
Accounting Acetates Animal Model Antibiotics Antioxidants Bacteria Burn injury Cessation of life Characteristics Complex Complication Cream Dermal Development Dose Drug Formulations Effectiveness Environment Erythema Evaluation Fibroblasts Free Radicals Gel Glutathione Goals Granulation Tissue Healed Histocompatibility Hydrogels Imagery In Vitro Individual Infection Inflammation Light Lipid Peroxidation Lipids Liquid substance Maintenance Measurement Methicillin Resistance Microbial Biofilms Modeling Nature Ointments Oxidative Stress Patients Performance Peroxidases Phase Preparation Process Production Property Pseudomonas aeruginosa Rattus Reactive Oxygen Species Reduced Glutathione Research Resolution Running Sepsis Silver Solubility Solutions Staphylococcus aureus Sterile coverings Sulfadiazine TNF gene Technology Testing Therapeutic Thick Tissues Topical Antibiotic Topical agent Toxic effect Toxin Treatment outcome Work Wound Healing antimicrobial antimicrobial drug base biomaterial compatibility carbene design healing improved in vivo innovation leukocyte activation microbial microbicide novel pathogen programs protein complex public health relevance resistant strain scale up wound

项目摘要

DESCRIPTION (provided by applicant): Three novel uncharged silver microbicides have been shown to be effective against a wide variety of pathogens have been shown to spontaneously form amorphous hydrogels when combined with glutathione will be formulated into two different ointment formulations and tested in an infected burn wound model in the rat. Formulation of the silver microbicides will be conducted at different concentrations for evaluation. The major specific aims of the proposed research involve the preparation & formulation/processing of the silver microbicides, determination of antimicrobial capacity, cyto-compatability, and evaluation in an infected burn wound model in the rat. The primary objectives of the proposed therapy are: 1) resolution of infection, 2) improvement of healing, and 3. reduction in overall oxidative stress. This innovative and rational approach to a topical antimicrobial therapy is founded on the basis of several different studies that have revealed promising bioapplicable attributes of these silver microbicide complexes. The end-goal of this project is to enable the next phase of development of one or more of these novel microbicidal formulations that will be targeted for the treatment of burn wounds while developing a greater understanding of the mechanisms by which these compounds work.

描述（由申请人提供）：已证明三种新型的未加成的银色微生物剂对多种病原体有效，当与谷胱甘肽结合使用时，已证明将自发形成无定形水凝胶，将被配合为两种不同的油膏配方，并在大鼠中受感染的烧伤模型中测试。银色霉素的配方将以不同的浓度进行评估。提出的研究的主要具体目的涉及银色生体的制备和配方/加工，确定抗菌剂能力，细胞兼容性以及评估大鼠感染的烧伤伤口模型。拟议治疗的主要目标是：1）感染的分辨率，2）改善愈合，3。总体氧化应激减少。这种对局部抗微生物治疗的创新和合理方法是基于几项不同的研究，这些研究揭示了这些银色杀菌剂复合物的有希望的生物涂抹属性。该项目的最终目标是使这些新型杀生型制剂的一个或多个开发的下一阶段能够用于治疗烧伤伤口，同时对这些化合物起作用的机制有更深入的了解。