Synthesis and Processing of Sulfonated Block Copolymer Biomaterials

磺化嵌段共聚物生物材料的合成与加工

• 批准号: 7109992
• 负责人: DAVID J VACHON
• 金额: $ 9.85万
• 依托单位: AEGIS BIOSCIENCES, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2007-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7109992
• 关键词: biomaterial development /preparation; combinatorial chemistry; hydropathy; molecular polarity; polymerization; polymers; solvolysis; sulfation; sulfur oxides; wound healing

DESCRIPTION (provided by applicant): Aegis BioSciences has developed a new and versatile class of anionic, nanostructured hydrogel materials with promising applications in wound care, anti-thrombogenic coatings, and drug delivery. These multi-phase block copolymers are derived from inexpensive, commercially available materials which are subsequently sulfonated. Indeed, growing interest in these materials demands attention to larger-scale and efficient synthesis and processing which is the focus of this proposal. Potential technological innovations include (1) new and efficient methods of sulfonation to achieve biomaterials with broad functionality and low overall manufacturing cost, (2) new solvent combinations of for processing of these materials into films and coatings, and (3) the potential for the development of water-based dispersions for processing. We believe that each of these innovations are realizable given the resources of a Phase I effort. A real commercial application of materials resulting from these improved manufacturing processes is a drug-eluting stent coating, and potential applications include dressings for wound management and matrices for mucosal delivery of drugs. There is an urgent need for biomaterials with a broad range of functionality (e.g., drug delivery, low tendency to induce clotting, facilitation of wound healing) that have low raw materials costs. Aegis' biomaterials meets this need, and increased commercial interest is driving a desire to focus on manufacturing issues with attention to economical processes for material preparation and fabrication. This Phase I proposal addresses key needs for the expansion of Aegis' materials into a growing healthcare marketplace.

描述（由申请人提供）：AEGIS Biosciences开发了一种新的且多功能的阴离子，纳米结构的水凝胶材料，具有有希望的伤口护理，抗直联涂层和药物输送。这些多相块共聚物来自廉价的，可商购的材料，后来被磺化。确实，对这些材料的兴趣日益增加，需要注意大规模，有效的综合和加工，这是该提案的重点。潜在的技术创新包括（1）新的有效的硫化方法，以实现具有广泛功能和整体制造成本较低的生物材料，（2）将这些材料加工成薄膜和涂料加工的新溶剂组合，以及（3）用于处理水基分散的潜力。我们认为，鉴于I阶段的资源，这些创新都可以实现。这些改进的制造过程产生的材料的真正商业应用是一种洗脱的支架涂料，潜在的应用包括伤口管理的敷料和用于药物粘膜输送的矩阵。迫切需要具有广泛功能性的生物材料（例如，药物输送，诱导凝结的低趋势，伤口愈合的促进），原材料成本较低。宙斯盾的生物材料满足了这一需求，而商业兴趣的提高正在促使人们渴望专注于对经济过程进行材料制备和制造的经济过程的制造问题。该阶段的提案解决了将宙斯盾材料扩展到不断增长的医疗保健市场的关键需求。