Lifestyle Interventions in Overweight and Obese Pregnant Women

超重和肥胖孕妇的生活方式干预

基本信息

批准号：
8734502
负责人：
DYMPNA GALLAGHER
金额：
$ 6.88万
依托单位：
ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-19 至 2017-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8734502
关键词：
Adipose tissue Adult Age Anthropometry Behavior Behavioral Biological Process Birth Blood Body Weight CCL2 gene Catchment Area Child Cost Analysis Counseling Data Dietary intake Dropout Enrollment Environment Fatty acid glycerol esters Funding Future Generations Glucose Guidelines High Density Lipoprotein Cholesterol Hospitals Infant Inflammatory Institute of Medicine (U.S.)Insulin Internet Intervention Intramuscular Knowledge Lead Leptin Life Lipids Magnetic Resonance Imaging Measurement Measures Metabolic Mothers Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Overweight Participant Physical activity Physicians Plasma Plasminogen Activator Inhibitor 1 Pregnancy Pregnant Women Prevalence Professional counselor Public Health Quality of life Questionnaires Randomized Controlled Trials Recommendation Risk Risk Factors Secondary to Socioeconomic Status Telephone Visceral Visit Weight Weight Gain Whole Body Plethysmography Woman adiponectin arm cohort cost effective group counseling improved in utero infant monitoring inflammatory marker lifestyle intervention low density lipoprotein triglyceride nutrition offspring pregnant prevent primary outcome reproductive subcutaneous treatment as usual

项目摘要

DESCRIPTION (provided by applicant): A randomized controlled trial is proposed to study the effect, in a cohort of racially and ethnically diverse group of overweight and obese pregnant women, of an Intensive Lifestyle Intervention (ILI) compared to Usual Care (UC) on gestational weight gain (GWG), infant fatness, and mothers' post-delivery weight retention. Women in the ILI arm will receive intensive counseling during pregnancy and group counseling after delivery regarding behavior, nutrition, and physical activity change. Visits to counselors will be weekly and additional telephone and internet contacts will occur. The mothers' will be assessed at 14 and 36 weeks of pregnancy and at 12 weeks and 52 weeks post-delivery. The measurements will be anthropometry, whole body MRI, EchoMRI, and whole body plethysmography (BodPod). The infants' measurements will be anthropometry, whole body MRI, EchoMRI, and whole body plethysmography (PeaPod) for fatness 12 weeks and 52 weeks. Mothers and children will have cardio-metabolic risk factors measured in plasma. Data will be collected regarding mothers' dietary intake and physical activity (questionnaires and accelerometry) to assist in counseling. Other data to be collected include questionnaires on quality of life, socio-economic status. Careful record will be kept of expenses in providing the ILI, so that cost analysis of the intervention can be calculated. The study is powered on the primary outcome, fatness of the infants at birth. We require 180 participants to attain appropriate power. We will enroll 210 so as to allow for some dropouts along the way. Each mother will be followed during pregnancy and for a year post delivery. Each infant will be followed for a year after birth. We have the ability o continue to follow these participants if further funding is forthcoming, as they are all local to or hospital's catchment area and our own physicians. If aims are achieved, namely that both children and mothers profit from the intervention, there should be a paradigm shift in how overweight pregnant women are treated. At present, there is a dearth of behavioral advice and intervention relating to GWG and physical activity provided to these women. Positive results from our study would provide evidence for ILI preventative intervention.

描述（由申请人提供）：提出了一项随机对照试验，以研究种族和种族多样化的超重和肥胖孕妇的群体，与妊娠体重（GWG）（GWG）相比，强烈的生活方式干预（ILI）（ILI）相比，进行了严格的生活方式干预（ILI），婴儿（GWG），婴儿肥胖，母亲的肥胖和母亲的重量。 ILI部门的妇女在怀孕期间将获得有关行为，营养和体育锻炼变化后的小组咨询的强化咨询。访问辅导员将每周访问，并将发生其他电话和互联网联系。母亲将在怀孕的14周和36周以及交付后12周和52周评估。测量值将是人体测量法，全身MRI，Echomri和全身杂质学（BODPOD）。婴儿的测量值将是人体测量法，全身MRI，Echomri和全身杂质学（PEAPOD），用于脂肪12周零52周。母亲和儿童将在血浆中测量的心脏代谢危险因素。将收集有关母亲的饮食摄入和体育锻炼（问卷和加速度计）的数据，以协助咨询。要收集的其他数据包括有关生活质量，社会经济地位的问卷。仔细记录提供ILI的费用，以便可以计算干预的成本分析。这项研究是主要结果，婴儿出生时的肥胖。我们要求180名参与者获得适当的权力。我们将注册210 允许一路上一些辍学。怀孕期间和分娩后一年都会遵循每个母亲。每个婴儿出生后一年。如果即将获得进一步的资金，我们有能力继续跟随这些参与者，因为他们都是本地或医院的集水区和我们自己的医生。如果实现目标，即儿童和母亲都从干预措施中获利，那么对超重孕妇的治疗方式应该会发生范式转变。目前，缺乏与GWG有关的行为建议和干预措施以及提供给这些妇女的体育锻炼。我们研究的积极结果将为ILI预防干预提供证据。