Multilevel Analysis of Self-regulation and Substance Abuse

自我调节和药物滥用的多层次分析

• 批准号: 8448219
• 负责人: TIFFANY A ITO
• 金额: $ 43.24万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8448219
• 关键词: Accounting; Address; Alcohol or Other Drugs use; American; Attention; Attitude; Awareness; Behavior; Behavioral; Behavioral Genetics; Belief; Cannabis; Cannabis Abuse; Chronic; Decision Making; Development; Drug usage; Failure; Gene Expression; Genes; Genetic; Goals; Growth; Health; Health behavior; Illicit Drugs; Individual; Informal Social Control; Intervention; Knowledge; Maintenance; Marijuana Dependence; Marijuana Smoking; Measures; Mediating; Modeling; Nature; Neurobiology; Neurosciences; Outcome; Pattern; Phenotype; Prefrontal Cortex; Prevalence; Process; Psychological Factors; Psychopathology; Public Health; Punishment; Receptor Gene; Research; Rewards; Risk Behaviors; Risk Factors; Schools; Self Assessment; Shapes; Short-Term Memory; Single Nucleotide Polymorphism; Source; Substance abuse problem; Thinking; Time; Translating; Work; base; behavior influence; cannabinoid receptor; cigarette smoking; design; effective intervention; executive function; expectation; high risk sexual behavior; innovation; longitudinal design; marijuana user; meetings; multilevel analysis; neuromechanism; operation; prototype; psychologic; relating to nervous system; response; social; social neuroscience; statistics; substance use prevention; therapy development

DESCRIPTION (provided by applicant): Awareness of the growing prevalence and deleterious effects of cannabis use has greatly increased over the past decade, making salient the need to better understand the mechanisms that underlie its initiation and progression of use. Self-regulation provides the means through which we control our thoughts and behavior to be in line with desired outcomes. As such, it is a fundamental component in substance use behavior. The purpose of the proposed research is to better understand marijuana use through a systematic assessment of self-regulatory processes related to marijuana use. It takes a multilevel approach, examining genetic, neural, and social/ behavioral influences on marijuana use. In particular, we hypothesize that genetic variability influences neurobiological and social psychological aspects of self-regulation involved in decision making regarding substance use. These neurobiological and social/behavioral deficits are then implicated in failures of self-regulation that are associated with the initiation, maintenance, and/or escalation of substance use. These processes will be explored by examining neural mechanisms associated with self-regulation (including sensitivity to rewards and punishments, response inhibition, and attention and working memory) as well as social psychological factors implicated in self-regulation (such as normative beliefs and prototypes of substance users) among three groups of cannabis users: (1) individuals exposed to marijuana use who have never initiated use, (2) individuals who have initiated use but not as heavy users, and (3) daily users. The association of specific genetic factors with neurobiological and social aspects of self-regulation and drug use will also be examined.

描述（由申请人提供）：在过去十年中，人们对大麻使用日益流行和有害影响的认识大大提高，因此迫切需要更好地了解其开始和发展的机制。自我调节提供了我们控制自己的思想和行为以符合预期结果的手段。因此，它是物质使用行为的基本组成部分。拟议研究的目的是通过对与大麻使用相关的自我监管过程进行系统评估，更好地了解大麻的使用。它采用多层次的方法，检查遗传、神经和社会/行为对大麻使用的影响。特别是，我们假设遗传变异影响物质使用决策中涉及的自我调节的神经生物学和社会心理学方面。这些神经生物学和社会/行为缺陷与自我调节失败有关，而自我调节与物质使用的开始、维持和/或升级有关。这些过程将通过检查与自我调节相关的神经机制（包括对奖励和惩罚的敏感性、反应抑制、注意力和工作记忆）以及与自我调节有关的社会心理因素（例如规范信念和原型）来探索。三类大麻使用者中的物质使用者）：（1）接触大麻但从未开始使用的个人，（2）已开始使用但不是重度使用者的个人，以及（3）日常使用者。还将检查特定遗传因素与自我调节和药物使用的神经生物学和社会方面的关联。

项目成果

Complementarity in daily marijuana and alcohol among emerging adults.

• DOI: 10.1037/adb0000771
• 发表时间: 2021-09
• 期刊: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
• 作者: Ito TA;Cordova KA;Skrzynski CJ;Bryan A
• 通讯作者: Bryan A

Can marijuana make it better? Prospective effects of marijuana and temperament on risk for anxiety and depression.

• DOI: 10.1037/adb0000109
• 发表时间: 2015-09
• 期刊: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
• 作者: Grunberg VA;Cordova KA;Bidwell LC;Ito TA
• 通讯作者: Ito TA

Anxiety increases sensitivity to errors and negative feedback over time.

• DOI: 10.1016/j.biopsycho.2021.108092
• 发表时间: 2021-05
• 期刊: Biological psychology
• 影响因子: 2.6
• 作者: Tobias MR;Ito TA
• 通讯作者: Ito TA