BRAIN LIPID METABOLISM, DENDRITES AND SYNAPSES IN AGING AND ALZHEIMER'S DISEASE

衰老和阿尔茨海默病中的脑脂质代谢、树突和突触

• 批准号: 8206522
• 负责人: GUOJUN BU
• 金额: $ 30.54万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8206522
• 关键词: Age; Age-Months; Aging; Alleles; Alzheimer' s Disease; Amyloid; Amyloid beta-Protein; Apolipoprotein E; Astrocytes; Biogenesis; Brain; Breeding; Cerebrosides; Cholesterol; Cholesterol Homeostasis; Coculture Techniques; Complement; Defect; Dendrites; Dendritic Spines; Dependovirus; Down-Regulation; Exhibits; Family; Glial Fibrillary Acidic Protein; Goals; Health; Homeostasis; Human; Impairment; Inferior; Knockout Mice; Knowledge; LDL-Receptor Related Protein 1; Late Onset Alzheimer Disease; Lipids; Lipoproteins; Low Density Lipoprotein Receptor; Measures; Mediating; Membrane; Memory impairment; Metabolic Pathway; Metabolism; Methods; Molecular; Movement Disorders; Mus; Neurites; Neuroglia; Neurons; Pathogenesis; Pathology; Pathway interactions; Peptides; Play; Process; Production; Prosencephalon; Protein Isoforms; Proteins; Public Health; Reagent; Risk; Risk Factors; Role; Signal Transduction; Staging; Synapses; System; Testing; Transgenic Mice; Vertebral column; abstracting; age related; aging brain; apolipoprotein E-3; apolipoprotein E-4; base; cholesterol sulfatide; density; lipid metabolism; lipid transport; nervous system disorder; novel; novel strategies; overexpression; particle; receptor; receptor expression; receptor function; small hairpin RNA; synaptic function; synaptogenesis