Definition of Angular Dependence of 1H-15N Coupling Constants in Amino Sugars

氨基糖中 1H-15N 偶联常数的角度依赖性的定义

• 批准号: 8149328
• 负责人: Rachel Schneerson
• 金额: $ 0.35万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8149328
• 关键词: Amino Sugars; Coupling; Dependence

Complete NMR characterization data have been measured for a series of fortimicin antibiotics, including the diamino-inositol component fortamine, fortimicins A, B, E, and isofortimicin. The data are comprised of 1D H-1 and C-13 NMR spectra, 1D H-1/N-15 HSQMBC, and 2D COSY, TOCSY, HSQC, and HMBC spectra. These data sets are under analysis. The 2D COSY and TOCSY are homonuclear H-1/H-1 data sets and are expected to confirm the H-1 NMR assignments. The 2D HSQC and HMBC spectra are heteronuclear H-1/C-13 data sets for confirmation of the C-13 assignments, while the 1D H-1/N-15 HSQMBC heteronuclear spectra contain information on the H-1/N-15 coupling constants.

已经测量了一系列Fortimicin抗生素的完整NMR表征数据，包括Diamino-氨基醇成分Fortamine，Fortimicins A，B，E和同二吡啶。数据由1D H-1和C-13 NMR光谱，1D H-1/N-15 HSQMBC以及2D COZY，TOCSY，HSQC和HMBC光谱。这些数据集正在分析中。 2D COZY和TOCSY是同核H-1/H-1数据集，并有望确认H-1 NMR分配。 2D HSQC和HMBC光谱是用于确认C-13分配的异核H-1/C-13数据集，而1D H-1/N-15 HSQMBC异核光谱包含有关H-1/N-15偶联常数的信息。

项目成果

Laurance David Hall.

劳伦斯·大卫·霍尔。

• DOI: 10.1016/b978-0-12-385520-6.00002-9
• 发表时间: 2011
• 期刊: Advances in carbohydrate chemistry and biochemistry
• 作者: Coxon,Bruce

Developments in the Karplus equation as they relate to the NMR coupling constants of carbohydrates.

• DOI: 10.1016/s0065-2318(09)00003-1
• 发表时间: 2009
• 期刊: ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY
• 作者: Coxon, Bruce