UDEL Subproject 3

UDEL子项目3

基本信息

批准号：
8727231
负责人：
Tania Lynn Roth
金额：
$ 17.3万
依托单位：
DELAWARE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8727231
关键词：
Adaptive Behaviors Animals Area Basic Science Behavior Behavioral Brain Brain region Centers of Research Excellence Cognitive Communication Complex Delaware Diagnosis Discrimination Disease Foundations Future Goals Hippocampus (Brain)Impairment Individual Investments Laboratories Lead Lesion Link Literature Medial Mediating Memory Memory impairment Methods Motor Nature Neurons Neurosciences Research Patients Pattern Performance Phase Play Population Post-Traumatic Stress Disorders Prefrontal Cortex Process Property Rattus Research Research Project Grants Role Sampling Schizophrenia Sensory Short-Term Memory Structure Symptoms Tactile Testing Theta Rhythm Time Training Visual base design environmental change executive function experience flexibility nervous system disorder neural circuit neurophysiology neuropsychiatry operation relating to nervous system research study response therapeutic development time interval

项目摘要

Making adaptive changes in behavior in response to environmental change is essential to survival and therefore is likely to be mediated by complex interactions within a network of distributed neural circuits. One brain region that has been implicated in behavioral flexibility is the medial prefrontal cortex (mPFC). Damage to this region causes impairments in executive function, planning, and working memory, which are all important components of behavioral flexibility. Recording studies have shown that single mPFC neurons show elevated firing rates during the delay period of tasks that require the retention of information over a temporal gap, such as delayed-match/nonmatch-to-sample, suggesting that mPFC neurons are involved in working memory. Other studies have shown that mPFC activity shows anticipatory increases in firing rate prior to the execution of a response, suggesting its role in planning imminent actions. The goal ofthe current proposal is to dissociate mPFC involvement in working memory from other functions by comparing the effects of mPFC lesions and the firing patterns of mPFC single neurons between two similar tasks: one that requires working memory and one that does not. Additionally, reversal of these tasks will reveal the role of the mPFC in behavioral flexibility. Finally, we will investigate the interaction between the hippocampus and mPFC by inactivating the hippocampus and concurrently recording mPFC single neurons during task acquisition, performance and reversal. The results will aid in developing a better understanding ofthe role of the mPFC in adaptive behavior, both alone and in conjunction with the hippocampus.

为了应对环境变化而做出适应性行为改变对于生存至关重要，因此可能是通过分布式神经回路网络内复杂的相互作用来介导的。与行为灵活性有关的一个大脑区域是内侧前额叶皮层（mPFC）。该区域的损伤会导致执行功能、计划和工作记忆受损，而这些都是行为灵活性的重要组成部分。记录研究表明，单个 mPFC 神经元在需要在时间间隔内保留信息的任务延迟期间表现出较高的放电率，例如延迟匹配/不匹配样本，这表明 mPFC 神经元参与工作记忆。其他研究表明，mPFC 活动在执行响应之前显示出预期的放电率增加，这表明它在计划即将采取的行动中的作用。当前提案的目标是通过比较两个相似任务（一项需要工作记忆和一项不需要工作记忆）之间 mPFC 损伤和 mPFC 单个神经元的放电模式的影响，将 mPFC 参与工作记忆与其他功能分离。此外，逆转这些任务将揭示 mPFC 在行为灵活性中的作用。最后，我们将通过灭活海马体并同时记录任务获取、执行和逆转过程中 mPFC 单个神经元来研究海马体和 mPFC 之间的相互作用。这些结果将有助于更好地理解 mPFC 在适应性行为中的作用，无论是单独的还是与海马体的结合。