Relation Between In-utero Vitamin D and Immune Function in Early Childhood

宫内维生素 D 与幼儿期免疫功能的关系

• 批准号: 8465523
• 负责人: Diane Ihn Ae Gilbert-Diamond
• 金额: $ 18.13万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8465523
• 关键词: 25-hydroxyvitamin D; Adult; Affect; Allergic; Allergic rhinitis; American; Antibiotics; Asthma; Atopic Dermatitis; Biological; Biological Markers; Birth; Breast Feeding; Bronchiolitis; CD4 Positive T Lymphocytes; Characteristics; Child; Child health care; Childhood; Chronic; Classification; Cohort Studies; Confounding Factors (Epidemiology); Data; Data Collection; Diagnosis; Diet; Dose; Enrollment; Environmental Risk Factor; Epidemiology; Family health status; Food Hypersensitivity; Frequencies; Genetic; Genetic Polymorphism; Genetic Status; Genotype; Gestational Age; Goals; Health; Health Care Costs; Helper-Inducer T-Lymphocyte; Hospitalization; Hypersensitivity; Immune; Immune system; Immunity; Incidence; Infant; Infection; Inflammation; Institute of Medicine (U.S.); Intake; International Unit; Interview; Lead; Life; Measures; Medical; Medical Records; Molecular Epidemiology; Morbidity - disease rate; Mothers; Multivitamin; New Hampshire; Nutritional; Obesity; Otitis Media; Outcome; Phenotype; Plasma; Play; Pneumonia; Population; Pregnant Women; Prospective Studies; Questionnaires; Recommendation; Reporting; Research Infrastructure; Resources; Respiratory Tract Infections; Risk; Role; Schools; Socioeconomic Status; Specimen; Supplementation; Systems Development; Time; Umbilical Cord Blood; Vitamin D; Vitamin D3 Receptor; Vitamins; Wheezing; Work; allergic response; atopy; cell type; ear infection; early childhood; environmental allergy; feeding; follow-up; gastrointestinal infection; genetic profiling; high risk; immune function; in utero; instrument; mental development; middle ear; population based; prenatal; prospective

Early childhood infection and allergies lead to substantial morbidity and health costs. Accumulating evidence suggests an important role of vitamin D in immunity. However, the studies relating vitamin D status to risk of atopy/allergy and infection in childhood are inconsistent; there are reports of both increased and decreased health risks according to vitamin D status. Moreover, there are few studies that explore the potential interaction between Vitamin D Receptor {VDR) genotypes, vitamin D status, and childhood immune outcomes. We aim to study how maternal and cord blood vitamin D concentration and infant VDR genetic profile are associated with immunity in the first three years of life within a large prospective birth cohort study. One thousand mother-child pairs are currently being enrolled in the New Hampshire Birth Cohort Study (NHBCS), a study that collects extensive data on nutritional, medical, environmental, and sociodemographic factors, as well as several biological specimens before and after delivery. The NHBCS will serve as a resource for biospecimen and data collection through questionnaires, follow-up interviews and medical record reviews. As part of the proposed study, we will measure maternal and cord blood concentrations of 25-hydroxyvitamin D (25(OH)D) and infant VDR genotypes in the NHBCS. First, we will study the associations between 25(OH)D concentrations with immune outcomes during the first 3 years of life. Atopy/allergy outcomes will include all diagnoses of atopy/allergy and specifically: atopic dermatitis, food and environmental allergies, allergic rhinitis, wheeze and asthma. Infection outcomes will include all infection diagnoses, and specifically respiratory and gastrointestinal infections. Analyses will evaluate potential confounding by factors such as gestational age at delivery, adiposity, and breast-feeding/formula feeding. Next, we will explore whether VDR polymorphisms are independently associated with the atopy/allergy and infection outcomes and whether they modify the association between maternal and cord blood 25(OH)D concentration and those outcomes. The goal of this work is to clarify the association between vitamin D status, a factor that is highly modifiable through supplementation of mothers and/or infants, with child health outcomes in the context of relevant environmental and genetic factors.

幼儿感染和过敏会导致大量的发病率和健康成本。积累证据 提出维生素D在免疫中的重要作用。但是，将维生素D状况与风险有关的研究 儿童时期的特应性/过敏和感染是不一致的。有报告增加和减少 健康风险根据维生素D状态。而且，很少有研究探索潜力 维生素D受体（VDR）基因型，维生素D状态和儿童免疫之间的相互作用 结果。我们旨在研究母体和脐带血维生素D浓度和婴儿VDR遗传 在大型前瞻性出生队列中，概况与生命的头三年有关 学习。目前正在新罕布什尔州出生队列中注册一千个母子双子 研究（NHBC），一项研究，该研究收集了有关营养，医学，环境和 社会人口统计学因素以及分娩前后的几个生物标本。 NHBC会 通过问卷调查，后续访谈和数据收集数据的资源 病历评论。作为拟议研究的一部分，我们将测量母亲和脐带血 NHBC中25-羟基维生素D（25（OH）D）和婴儿VDR基因型的浓度。首先，我们会的 研究在25（OH）D浓度之间与免疫结果之间的关联 生活。特应性/过敏结果将包括所有特应性/过敏的所有诊断：特应性皮炎，食物 和环境过敏，过敏性鼻炎，喘息和哮喘。感染结果将包括所有感染 诊断，特别是呼吸和胃肠道感染。分析将评估潜力 诸如胎龄，肥胖和母乳喂养/配方奶粉等因素混淆。 接下来，我们将探讨VDR多态性是否与特应性/过敏和 感染结果以及它们是否改变了母体和脐带血25（OH）D之间的关联 集中度和这些结果。这项工作的目的是阐明维生素D之间的关联 身份，这是通过补充母亲和/或婴儿的高度修改的因素，儿童健康 在相关的环境和遗传因素的背景下的结果。