Cognitive and Affective Neuroscience of Atypical Empathy in Conduct Disorder

品行障碍中非典型同理心的认知和情感神经科学

基本信息

批准号：
8038459
负责人：
JEAN DECETY
金额：
$ 39.56万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8038459
关键词：
11 year old Address Adolescence Adolescent Adult Affect Affective Aggressive behavior Amygdaloid structure Anatomy Anisotropy Anterior Antisocial Personality Disorder Area Arousal Attention Autonomic nervous system Awareness Basic Science Behavior Brain Cessation of life Chicago Child Childhood Commit Complex Conduct Disorder Craniocerebral Trauma Crime Data Deceleration Deformity Detection Diagnostic Diffusion Diffusion Magnetic Resonance Imaging Distress Dorsal Emotional Emotions Empathy Environment Exhibits Female Fiber Foundations Functional Magnetic Resonance Imaging Future Goals Health Heart Rate Home environment Homicide Imprisonment Individual Differences Informal Social Control Injury Insula of Reil Lateral Laws Lead Learning Life Style Longevity Magnetic Resonance Imaging Measurement Measures Medial Mental Depression Mental Health Mental disorders Mind Modeling Molecular Motor National Institute of Mental Health Nature Neurobiology Pain Patient Self-Report Pattern Perception Persons Physical aggression Physiology Play Population Prevention Process Property Psychophysiology Public Health Reaction Regulation Research Research Personnel Resources Rest Rewards Risk Role Running Sampling Sensory Series Signal Transduction Social Interaction Somatosensory Cortex Staging Stimulus Structure Substance abuse problem Suicide Symptoms System Testing Theft Translating Translational Research Universities Ventral Striatum Violence Youth affective neuroscience anti social association cortex base behavior measurement brain behavior bullying cingulate cortex cognitive control cognitive neuroscience design emerging adult emotion regulation executive function experience genetic analysis gray matter heart rate variability hemodynamics high risk innovation interest male meetings midbrain central gray substance morphometry neural circuit neuroimaging novel strategies pleasure psychologic relating to nervous system response sex social stimulus processing theories translational study visual stimulus white matter

项目摘要

DESCRIPTION (provided by applicant): The proposed study will comparatively evaluate three hypotheses regarding biopsychological mechanisms underpinning atypical empathy in conduct disorder (CD). Significance: Antisocial behavior across the lifespan creates an enormous public health burden. Despite the indisputable importance of social factors, much remains to be learned about neurobiological factors involved in childhood CD. Empathic concern for others has been hypothesized to play a key role in inhibiting aggression and other forms of antisocial behavior and deficits in empathy lead to profound disturbances in social interaction. Therefore, studies of the role of atypical empathic concern in childhood CD are of great importance. Innovation: The proposed study would be the first neurobiological study of atypical empathy in pre-adolescent children with CD using functional magnetic resonance imaging. It will provide the empirical basis for a much-needed integrative biopsychological model of the basic brain-behavior processes involved in dysfunctional empathy in CD. Multiple levels of scientific analysis are fundamentally important when addressing complex phenomena such as CD. Too often, the assessment of empathy in both healthy and psychiatric populations has relied solely on self-report measures that provide only one kind of information. Approach: To achieve our scientific aims we will obtain from male and female 9-11 year old children who meet diagnostic criteria for CD (N = 60) and a group of non-CD control children (N = 60) a number of neurobiological and behavioral measures of responses to viewing others in pain. These measures include: (a) structural brain anatomy and functional connectivity (b) neuro-hemodynamic responses to visual stimuli that typically evoke empathic concern, (c) subjective ratings of the affect elicited by viewing others in pain, (d) behavioral measures of approach tendencies to stimuli depicting pain in others, and (e) measures of autonomic nervous system activity. We hypothesize that when viewing others in pain, children with CD will exhibit greater neuro-hemodynamic response in areas of the pain matrix involved in both the sensory-discriminative and affective aspects of the first-hand experience of pain. The behavioral measures will indicate that children with CD experience a more positive affective response to seeing others in pain than comparison children. Furthermore, children with CD will exhibit both less anatomical connection and functional connectivity between the PFC and the amygdala, which would be consistent with diminished self-regulation of emotional aspects of empathic concern for others in distress. Environment and Investigators: Our experienced team of investigators and consultants includes experts on CD, functional neuroimaging and cognitive neuroscience, especially in the area of empathy, and psychophysiological measurement. The University of Chicago provides a strong environment and resources for this project. PUBLIC HEALTH RELEVANCE: Because most crime is committed by juveniles, antisocial behavior in youth creates an enormous public health burden. Antisocial behavior not only harms victims in physical and psychological ways, but antisocial youth are at high risk for incarceration, injury and death from violence, substance abuse, and suicide. The proposed translational study will lead to an integrative understanding of basic brain-behavior processes involved in dysfunctional empathic concern in children with conduct disorder and suggest new approaches to treatment and prevention.

描述（由申请人提供）：拟议的研究将比较评估关于行为障碍（CD）中非典型同理心的生物心理学机制的三个假设。意义：整个生命周期的反社会行为造成了巨大的公共健康负担。尽管社会因素的重要性无可争议，但关于儿童 CD 所涉及的神经生物学因素仍有很多东西需要了解。据推测，对他人的同理心关注在抑制攻击性和其他形式的反社会行为方面发挥着关键作用，而同理心的缺陷会导致社交互动的严重障碍。因此，研究非典型共情关注在儿童CD中的作用具有重要意义。创新：拟议的研究将是第一个使用功能磁共振成像对患有 CD 的青春期前儿童的非典型共情进行的神经生物学研究。它将为 CD 中同理心功能障碍所涉及的基本大脑行为过程急需的综合生物心理学模型提供经验基础。在解决 CD 等复杂现象时，多层次的科学分析至关重要。通常，对健康人群和精神病人群的同理心评估仅依赖于仅提供一种信息的自我报告措施。方法：为了实现我们的科学目标，我们将从符合 CD 诊断标准的 9-11 岁男性和女性儿童 (N = 60) 和一组非 CD 对照儿童 (N = 60) 中获得一些神经生物学和观察他人痛苦时的反应的行为测量。这些措施包括：（a）大脑结构解剖学和功能连接性（b）对视觉刺激的神经血流动力学反应，通常会引起共情关注，（c）对观看他人痛苦所引起的影响的主观评价，（d）行为测量接近描述他人疼痛的刺激的倾向，以及（e）自主神经系统活动的测量。我们假设，当看到其他人遭受痛苦时，患有 CD 的儿童在涉及第一手疼痛体验的感觉辨别和情感方面的疼痛矩阵区域会表现出更大的神经血流动力学反应。行为测量表明，与对照儿童相比，患有克罗恩病的儿童在看到他人痛苦时会产生更积极的情感反应。此外，患有克罗恩病的儿童前额皮层和杏仁核之间的解剖学联系和功能联系都较少，这与对处于困境的他人的移情关心的情绪方面的自我调节能力减弱是一致的。环境和研究人员：我们经验丰富的研究人员和顾问团队包括 CD、功能神经影像和认知神经科学领域的专家，特别是同理心和心理生理测量领域的专家。芝加哥大学为本项目提供了强大的环境和资源。公共卫生相关性：由于大多数犯罪是青少年实施的，青少年的反社会行为造成了巨大的公共卫生负担。反社会行为不仅对受害者的身体和心理造成伤害，而且反社会青少年面临着因暴力、药物滥用和自杀而入狱、受伤和死亡的高风险。拟议的转化研究将导致对行为障碍儿童功能失调的共情关注所涉及的基本大脑行为过程的综合理解，并提出新的治疗和预防方法。