Cognitive and Affective Neuroscience of Atypical Empathy in Conduct Disorder

品行障碍中非典型同理心的认知和情感神经科学

基本信息

批准号：
8243471
负责人：
JEAN DECETY
金额：
$ 36.29万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8243471
关键词：
11 year old Address Adolescence Adolescent Adult Affect Affective Aggressive behavior Amygdaloid structure Anatomy Anisotropy Anterior Antisocial Personality Disorder Area Arousal Attention Autonomic nervous system Awareness Basic Science Behavior Brain Cessation of life Chicago Child Childhood Commit Complex Conduct Disorder Craniocerebral Trauma Crime Data Deceleration Deformity Detection Diagnostic Diffusion Diffusion Magnetic Resonance Imaging Distress Dorsal Emotional Emotions Empathy Environment Exhibits Female Fiber Foundations Functional Magnetic Resonance Imaging Future Goals Heart Rate Home environment Homicide Imprisonment Individual Differences Informal Social Control Injury Insula of Reil Lateral Laws Lead Learning Life Style Longevity Magnetic Resonance Imaging Measurement Measures Medial Mental Depression Mental Health Mental disorders Mind Modeling Molecular Motor National Institute of Mental Health Nature Neurobiology Pain Patient Self-Report Pattern Perception Persons Physical aggression Physiology Play Population Prevention Process Property Psychophysiology Public Health Reaction Regulation Research Research Personnel Resources Rest Rewards Risk Role Running Sampling Sensory Series Signal Transduction Social Interaction Somatosensory Cortex Staging Stimulus Structure Substance abuse problem Suicide Symptoms System Testing Theft Translating Translational Research Universities Ventral Striatum Violence Youth affective neuroscience anti social association cortex base behavior measurement brain behavior bullying cingulate cortex cognitive control cognitive neuroscience design emerging adult emotion regulation executive function experience genetic analysis gray matter heart rate variability hemodynamics high risk innovation interest male meetings midbrain central gray substance morphometry neural circuit neuroimaging novel strategies pleasure psychologic relating to nervous system response sex social stimulus processing theories translational study visual stimulus white matter

项目摘要

Project Summary The proposed study will comparatively evaluate three hypotheses regarding biopsychological mechanisms underpinning atypical empathy in conduct disorder (CD). Significance: Antisocial behavior across the lifespan creates an enormous public health burden. Despite the indisputable importance of social factors, much remains to be learned about neurobiological factors involved in childhood CD. Empathic concern for others has been hypothesized to play a key role in inhibiting aggression and other forms of antisocial behavior and deficits in empathy lead to profound disturbances in social interaction. Therefore, studies of the role of atypical empathic concern in childhood CD are of great importance. Innovation: The proposed study would be the first neurobiological study of atypical empathy in pre-adolescent children with CD using functional magnetic resonance imaging. It will provide the empirical basis for a much-needed integrative biopsychological model of the basic brain-behavior processes involved in dysfunctional empathy in CD. Multiple levels of scientific analysis are fundamentally important when addressing complex phenomena such as CD. Too often, the assessment of empathy in both healthy and psychiatric populations has relied solely on self-report measures that provide only one kind of information. Approach: To achieve our scientific aims we will obtain from male and female 9-11 year old children who meet diagnostic criteria for CD (N = 60) and a group of non-CD control children (N = 60) a number of neurobiological and behavioral measures of responses to viewing others in pain. These measures include: (a) structural brain anatomy and functional connectivity (b) neuro-hemodynamic responses to visual stimuli that typically evoke empathic concern, (c) subjective ratings of the affect elicited by viewing others in pain, (d) behavioral measures of approach tendencies to stimuli depicting pain in others, and (e) measures of autonomic nervous system activity. We hypothesize that when viewing others in pain, children with CD will exhibit greater neuro-hemodynamic response in areas of the pain matrix involved in both the sensory-discriminative and affective aspects of the first-hand experience of pain. The behavioral measures will indicate that children with CD experience a more positive affective response to seeing others in pain than comparison children. Furthermore, children with CD will exhibit both less anatomical connection and functional connectivity between the PFC and the amygdala, which would be consistent with diminished self-regulation of emotional aspects of empathic concern for others in distress. Environment and Investigators: Our experienced team of investigators and consultants includes experts on CD, functional neuroimaging and cognitive neuroscience, especially in the area of empathy, and psychophysiological measurement. The University of Chicago provides a strong environment and resources for this project.

项目概要拟议的研究将比较评估有关生物心理学机制的三种假设行为障碍（CD）中非典型同理心的基础。意义：整个生命周期的反社会行为造成巨大的公共卫生负担。尽管社会因素的重要性无可争议，但关于儿童 CD 所涉及的神经生物学因素仍有待了解。对他人的同理心关心被假设在抑制攻击性和其他形式的反社会行为和缺陷方面发挥关键作用缺乏同理心会导致社交互动中的严重干扰。因此，对非典型作用的研究移情关怀在儿童CD中非常重要。创新：拟议的研究将是第一个使用功能磁对青春期前 CD 儿童非典型共情进行神经生物学研究共振成像。它将为急需的综合生物心理学模型提供经验基础 CD 中同理心功能失调所涉及的基本大脑行为过程。多层次科学在解决 CD 等复杂现象时，分析至关重要。很多时候，对健康人群和精神病人群的同理心评估仅依赖于自我报告措施仅提供一种信息。方法：为了实现我们的科学目标，我们将从男性那里获得符合CD诊断标准的9-11岁女性儿童（N = 60）和一组非CD对照儿童（N = 60）对看到他人痛苦时的反应进行了一些神经生物学和行为测量。这些措施包括：(a) 大脑结构解剖学和功能连接性 (b) 神经血流动力学对通常引起共情关注的视觉刺激的反应，（c）对所引起的影响的主观评价观察他人的痛苦，(d) 接近描绘他人痛苦的刺激倾向的行为测量，以及 (e) 自主神经系统活动的测量。我们假设，当孩子们看到别人遭受痛苦时， CD 患者的疼痛基质区域会表现出更大的神经血流动力学反应，这些区域涉及疼痛的第一手经验的感觉辨别和情感方面。行为措施将表明患有 CD 的儿童在看到他人遭受痛苦时会产生更积极的情感反应比较的孩子。此外，患有 CD 的儿童会表现出较少的解剖学联系和功能性联系。 PFC 和杏仁核之间的连接，这与自我调节能力的减弱是一致的对处于困境中的他人的同情关怀的情感方面。环境和研究人员：我们的经验丰富的研究人员和顾问团队包括 CD、功能神经影像和认知神经科学，特别是同理心和心理生理学测量领域。这芝加哥大学为本项目提供了强大的环境和资源。