Children's Oncology Group Statistics and Data Center Grant

儿童肿瘤学组统计和数据中心拨款

• 批准号: 8914171
• 负责人: Meenakshi Devidas
• 金额: $ 24.63万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-20 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8914171
• 关键词: Children; Oncology; Group; Statistics; Data

The COG SDC is responsible for all statistical and data operations within the COG. It also supports many of the administrative activities of the COG. The IT support required for all statistical and data center operations is also provided by the SDC grant. The specific aims of the SDC are to: 1. Collaborate on the development of the COG's scientific agenda, as full members of Disease and Modality Committees 2. Provide leadership in the design of COG research, collaborating on the development of study pre-concepts, concepts, and protocols and providing study statistical considerations, includingsample size calculations and interim monitoringplans 3. Collaborate on the development of study case report forms used to collect the minimal data required for the evaluation of the study aims 4. Maintain a centralized remote data entry system to collect study data from COG institutions,resource centers, and reference laboratories, and maintainquality control procedures to assure the accuracy of COG research data 5. Monitor study data submitted by participating COG institutions,monitor the timeliness of data submissionand provide institutionswith expectancy and delinquencyreports, review submitted data, coordinate the collection and review of materials collected for modality reviews (pathology, surgery, radiation therapy), and coordinate study committee review of study data 6. Monitor study conduct, includingaccrual, patient safety, and study outcome; prepare public protocol progress reports for the COG and confidential reports of interim outcome data for the COG's Data Monitoring Committees 7. Collaborate on the production of abstracts and manuscripts reporting the results of COG science 8. Conduct research on statistical methods that have direct relevance to COG's research goals and conduct special analyses (e.g., on prognostic factors, outcome for specific patient subsets, etc.), taking advantage of the wealth of information contained in the group's research databases 9. Provide statistical collaboration for the COG's correlative laboratory research agenda. 10. Collaborate with members of the Group Operations Center in the completion of various administrative activities, including institutional audits and institutional performance monitoring 11. Provide education and training to the Group membership, including collaboration on the trainingof new study chairs, collaboration on new and continuingeducation training for institutionalclinical research associates and presentations on statistical issues of interest to the Group membership.

COG SDC负责COG内的所有统计和数据操作。它还支持许多 齿轮的行政活动。所有统计和数据中心操作所需的IT支持也是 由SDC赠款提供。 SDC的具体目的是： 1。作为疾病和方式的正式成员而合作开发COG的科学议程 委员会 2。在齿轮研究设计方面提供领导地位，合作研究了研究前的研究， 概念和协议以及提供研究统计考虑因素，包括样本尺寸计算和 临时监测计划 3.合作开发研究案例报告表格，用于收集最低数据 研究目的的评估 4.维护一个集中式远程数据输入系统，以从COG机构，资源中心， 和参考实验室以及维护质量控制程序，以确保COG研究数据的准确性 5。通过参与COG机构提交的监视研究数据，监视数据提交和 提供具有预期和犯罪报告的机构，审核提交的数据，协调集合 并审查用于模态综述（病理，手术，放射治疗）和坐标的材料 研究委员会审查研究数据 6。监测研究行为，包括伴随，患者的安全和研究结果；准备公共协议进度 COG的报告和机密报告COG数据监视的临时结果数据 委员会 7。在报告cog科学结果的摘要和手稿的生产下合作 8.对与COG的研究目标有直接相关的统计方法进行研究并进行特殊 分析（例如，关于预后因素，特定患者子集的结果等），利用财富 小组研究数据库中包含的信息 9。为COG的相关实验室研究议程提供统计合作。 10。与小组运营中心成员合作完成各种管理 活动，包括机构审计和机构绩效监控 11。向小组成员提供教育和培训，包括在新研究的培训方面合作 椅子，关于机构研究伙伴的新的和持续教育培训的合作 有关小组成员感兴趣的统计问题的演讲。

项目成果

Considerations in the design of clinical trials for pediatric acute lymphoblastic leukemia.

• DOI: 10.4155/cli.13.71
• 发表时间: 2013-09
• 期刊: Clinical investigation
• 作者: Devidas M;Anderson JR
• 通讯作者: Anderson JR

Favorable survival maintained in children who have myeloid leukemia associated with Down syndrome using reduced-dose chemotherapy on Children's Oncology Group trial A2971: a report from the Children's Oncology Group.

• DOI: 10.1002/cncr.27484
• 发表时间: 2012-10-01
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Sorrell AD;Alonzo TA;Hilden JM;Gerbing RB;Loew TW;Hathaway L;Barnard D;Taub JW;Ravindranath Y;Smith FO;Arceci RJ;Woods WG;Gamis AS
• 通讯作者: Gamis AS

Mutational analysis of candidate tumor-associated genes in acute megakaryoblastic leukemia.

急性巨核细胞白血病候选肿瘤相关基因的突变分析。

• DOI: 10.1038/leu.2009.159
• 发表时间: 2009
• 期刊: Leukemia
• 影响因子: 11.4
• 作者: Bhat,R;Malinge,S;Gamis,AS;Sorrell,AD;Hilden,JM;Ketterling,RP;Paietta,E;Tallman,MS;Crispino,JD
• 通讯作者: Crispino,JD

The impact of surgical excision in chest wall rhabdomyosarcoma: a report from the Children's Oncology Group.

胸壁横纹肌肉瘤手术切除的影响：儿童肿瘤学组的报告。

• DOI: 10.1016/j.jpedsurg.2007.12.021
• 发表时间: 2008
• 期刊: Journal of pediatric surgery
• 影响因子: 2.4
• 作者: Hayes-Jordan,Andrea;Stoner,JulieA;Anderson,JamesR;Rodeberg,David;Weiner,Gene;Meyer,WilliamH;Hawkins,DougS;Arndt,CarolaAS;Paidas,Charles;Children'sOncologyGroup
• 通讯作者: Children'sOncologyGroup

Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children's Oncology Group Report.

• DOI: 10.1038/leu.2009.262
• 发表时间: 2010-02
• 期刊: Leukemia
• 影响因子: 11.4