Fully Compensated Dynamic Shim System for In Vivo MRI and MRS

用于体内 MRI 和 MRS 的完全补偿动态匀场系统

• 批准号: 8220721
• 负责人: Piotr M Starewicz
• 金额: $ 36.37万
• 依托单位: RESONANCE RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8220721
• 关键词: Accounting; Affect; Air; Amplifiers; Animal Experimentation; Animals; Bone Tissue; Brain; Calibration; Clinical; Communities; Computer software; Data; Data Quality; Databases; Dependence; Development; Diagnostic Errors; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Echo-Planar Imaging; Ensure; Environment; Financial compensation; Functional Magnetic Resonance Imaging; Grant; Health; Human; Image; Imagery; Injury; Institution; Knowledge; Label; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetism; Metabolic; Methods; Modification; Morphologic artifacts; Operative Surgical Procedures; Organ; Performance; Phase; Physics; Positioning Attribute; Predisposition; Process; Protocols documentation; Reporting; Research; Residual state; Resolution; Sampling; Signal Transduction; Slice; Small Business Technology Transfer Research; Spectrum Analysis; System; Techniques; Technology; Time; Tissues; Universities; Update; Variant; Vendor; Work; base; clinical application; commercialization; cost effective; design; disease diagnosis; flexibility; human tissue; imaging modality; improved; in vivo; interest; magnetic field; magnetic resonance spectroscopic imaging; method development; new technology; next generation; novel strategies; operation; prototype; quality assurance; soft tissue; software development; spectroscopic imaging; tool

DESCRIPTION (provided by applicant): Functional MRI, diffusion MRI and MR spectroscopy and spectroscopic imaging have great potential for the study and diagnosis of disease and injury, and guiding surgical therapy. All of these methods benefit greatly from the added sensitivity, resolution and contrast from high field strength magnets (3T and above). However, the advantages of higher magnetic fields have not been fully realized due to the increasingly confounding effects of magnetic field inhomogeneity (MFI) caused by magnetic susceptibility differences between air and tissue. MFI leads to signal loss and spatial distortion in MRI and loss in spectral resolution and sensitivity in MRS. The loss of reliability due to these artifacts is a major reason why these techniques have not seen wide use in clinical applications. Current methods of magnetic field homogenization (i.e. shimming) work well on small volumes but are inadequate over larger objects, like the entire human brain. Over the last decade, the MR group at Yale University has developed the technique of dynamic shim updating (DSU) which allows greatly improved magnetic field homogeneity over extended regions. DSU divides a global 3D problem into a number of slices over which adequate magnetic field homogeneity can be achieved. Dynamically updating the pre-determined slice shims in sync with the multi-slice MRI sequence ensures optimal homogeneity for all slices. Following a successful completion of the Phase I STTR grant, the current Phase II application continues the work towards commercialization of DSU. Specifically, DSU hardware will be further improved and combined with professional software to automatically set up the unit. Since DSU is significantly more complicated than regular shimming, additional software will be provided for the every day operation of the unit by standard MR users. Since MFI affects almost all facets of in vivo NMR, the successful commercialization of DSU will have major impacts on the clinical application of MRI and MRS and can thus be labeled as highly significant. PUBLIC HEALTH RELEVANCE: Magnetic resonance imaging (MRI) and spectroscopy (MRS) are the leading techniques to obtain high-quality images and metabolic profiles of intact human tissues in health and disease. Unfortunately, spatial variations in magnetic field strength introduced by the sample can severely degrade the quality of MRI and MRS data, such that distinction of normal from diseased tissues may be compromised. Current technology is not able to completely cancel the spatial magnetic field variations. The current project focuses on the development of novel technology that can significantly reduce spatial magnetic field variations, thus leading to greatly increased MRI and MRS data quality.

描述（由申请人提供）：功能性MRI，扩散MRI和MR光谱和光谱成像具有巨大的研究和诊断疾病和损伤的潜力，以及指导手术治疗。所有这些方法都从高磁场强度磁铁（3T及以上）的增加的灵敏度，分辨率和对比度中受益匪浅。然而，由于磁场不均匀性（MFI）的越来越混杂的影响，由于空气和组织之间的磁敏感性差异，较高的磁场的优势尚未完全实现。 MFI导致MRI的信号丢失和空间失真，以及MRS中光谱分辨率和灵敏度的损失。由于这些技术而导致的可靠性丧失是这些技术在临床应用中没有广泛使用的主要原因。当前的磁场均匀化方法（即圆形）在少量体积上很好地工作，但在较大的物体上（如整个人类大脑）不足。在过去的十年中，耶鲁大学的MR组开发了动态垫片更新技术（DSU），该技术允许在扩展区域大大改善磁场均匀性。 DSU将一个全局的3D问题分为许多切片，在这些切片上可以实现足够的磁场同质性。动态更新预定的切片垫片与多片MRI序列同步可确保所有切片的最佳同质性。在成功完成I期STTR赠款之后，当前的II期应用程序继续致力于DSU的商业化。具体而言，DSU硬件将得到进一步改进，并与专业软件结合使用，以自动设置该设备。由于DSU比常规光盘要复杂得多，因此标准MR用户将为设备的每日操作提供其他软件。由于MFI几乎影响了体内NMR的所有方面，因此DSU的成功商业化将对MRI和MRS的临床应用产生重大影响，因此可以将其标记为非常重要。公共卫生相关性：磁共振成像（MRI）和光谱学（MRS）是获得健康和疾病中完整人体组织的高质量图像和代谢谱的领先技术。不幸的是，样品引入的磁场强度的空间变化会严重降低MRI和MRS数据的质量，从而使正常组织与患病组织的区别可能受到损害。当前的技术无法完全取消空间磁场变化。当前的项目着重于可以显着减少空间磁场变化的新技术的开发，从而大大提高了MRI和MRS数据质量。