Hybrid Organic-Inorganic Composite Materials for Bone Repairs

用于骨修复的有机-无机杂化复合材料

• 批准号: 8016070
• 负责人: ADEREMI R OKI
• 金额: $ 10.65万
• 依托单位: PRAIRIE VIEW AGRI & MECH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8016070
• 关键词: 3-Dimensional; Affect; Allografting; Apatites; Area; Autologous Transplantation; Biocompatible; Bioglass; Biomedical Research; Body Fluids; Bone Diseases; Bone Regeneration; Bone Tissue; Carbon Nanotubes; Cells; Cellular biology; Ceramics; Chemicals; Collagen; Development; Engineering; Exhibits; Failure; Fracture; Funding; Gel; Glass; Human; Hybrids; Hydroxyapatites; Hydroxyl Radical; Individual; Lead; Mechanics; Mind; Minerals; Performance; Phase; Phosphonic Acids; Phosphoric Acids; Polyesters; Polyethylenes; Polymers; Porosity; Process; Productivity; Property; Publications; Research; Research Personnel; Scholarship; Science; Side; Silanes; Simulate; Sodium Chloride; Solutions; Stress; Structure; Students; Surface; Techniques; Tissue Engineering; Tube; Weight-Bearing state; Work; base; bone; bone repair material; carboapatite; carboxyl radical; clinical application; fetal; improved; interest; interfacial; light weight; nanoapatite; nanocomposite; particle; poly(propylene fumarate); repaired; scaffold; silane

DESCRIPTION (provided by applicant): Bioglass and Bioceramics have found clinical applications in bone repairs. However, because of their brittleness and poor mechanical properties, their applications are generally limited to non load bearing conditions. Polymer composites fabricated by shear mixing of bioactive inorganic phase (bioglass, ceramics, or hydroxyl apatite) with high mechanical performance biocompatible organic polymer phase are eliciting strong interest because of the similarity with natural bone, a composite of apatite and collagen matrix. The poor interfacial bonding between the organic polymer phase and the inorganic apatite or bioglass phase in synthetic composites generally give rise to lower stress transfer ability in applications as scaffolds for bone tissue engineering especially under load bearing condition. To achieve high stress transfer, chemical integration of the two phases would be required. The specific aims of the work proposed here are: 1. To fabricate by sol-gel techniques 3-D macroporous hybrid materials incorporating inorganic bioglass (CaO-SiO2-ZnO) with a variety of organic phases: a.Biocompatible organic polymers , poly(propylene fumarate) and poly(trimethoxysilyl)propylmethacrylate (PTPMA)-chemically integrated with bioglass. b.Silane functionalized carbon nanotubes integrated with bioglass by sol-gel processing. c.Nucleation of nano-apatite on side wall functionalized carbon nanotubes (-COO-, HO- and phosphonic acid groups) using hydrothermal technique. These fabricated composites are expected to show excellent bone bondind ability arising from bioglass with improved mechanical properties and thus find application, especially as scaffolds in bone tissue engineering. We shall also develop composition-property relationship to provide guidance for predicting how fabrication variables, (ratio of organic : inorganic matrix, porosity, type of polymer and polymer to co-polymer ratio) affect bioactivity (bone bonding ability) when compared to bulk bioglasses and mechanical properties compared to natural bone. The bioactivity will be conducted using simulated body fluid and cell studies using human fetal osteoblastic cells. Another aim of the proposed work is to bring together complementary expertise to support strong biomedical research at PVAMU and specifically, enhance research productivity and scholarship of respective investigators. This proposed study will fabricate hybrid composites materials with excellent bone bonding ability and improved mechanical properties without the problems associated with the use of autografts and allografts in repairing defective or diseased bone This project involves the fabrication of synthetic composite materials that can be utilized in bone repair or treatment of bone diseases. These lightweight composites are biocompatible and are able to stimulate bone mineral formation in body fluid.

描述（由申请人提供）：生物玻璃和生物陶瓷已在骨修复中得到临床应用。然而，由于其脆性和机械性能较差，其应用一般仅限于非承载条件。通过将生物活性无机相（生物玻璃、陶瓷或羟基磷灰石）与高机械性能生物相容性有机聚合物相剪切混合而制备的聚合物复合材料由于与天然骨（磷灰石和胶原基质的复合材料）相似而引起了人们的浓厚兴趣。合成复合材料中有机聚合物相与无机磷灰石或生物玻璃相之间较差的界面结合通常导致在骨组织工程支架应用中应力传递能力较低，特别是在承载条件下。为了实现高应力传递，需要将两相进行化学整合。这里提出的工作的具体目标是： 1.通过溶胶-凝胶技术制造将无机生物玻璃（CaO-SiO2-ZnO）与各种有机相相结合的3D大孔杂化材料：a.生物相容性有机聚合物，聚（富马酸丙烯酯）和聚（三甲氧基硅烷基）甲基丙烯酸丙酯（PTPMA）-与生物玻璃化学结合。 b.通过溶胶-凝胶处理将硅烷功能化的碳纳米管与生物玻璃集成。 c.使用水热技术在侧壁功能化碳纳米管（-COO-、HO-和膦酸基团）上成核纳米磷灰石。这些制造的复合材料预计将表现出由生物玻璃产生的优异的骨粘合能力，并具有改善的机械性能，从而得到应用，特别是作为骨组织工程中的支架。我们还应开发成分-性能关系，为预测与块状生物玻璃相比制造变量（有机：无机基质的比率、孔隙率、聚合物类型以及聚合物与共聚物的比率）如何影响生物活性（骨结合能力）提供指导与天然骨相比的机械性能。生物活性将通过模拟体液和使用人类胎儿成骨细胞的细胞研究进行。拟议工作的另一个目标是汇集互补的专业知识，以支持 PVAMU 强大的生物医学研究，特别是提高各自研究人员的研究生产力和学术水平。这项拟议的研究将制造具有优异骨粘合能力和改善机械性能的混合复合材料，而不会出现与使用自体移植物和同种异体移植物修复缺陷或患病骨骼相关的问题。该项目涉及制造可用于骨修复的合成复合材料或治疗骨骼疾病。这些轻质复合材料具有生物相容性，能够刺激体液中骨矿物质的形成。