Translational Analyses of Chronic Aberrant Behavior Across the Life Span

整个生命周期慢性异常行为的转化分析

• 批准号: 8299043
• 负责人: MICHAEL F CATALDO
• 金额: $ 93.37万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8299043
• 关键词: Adaptive Behaviors; Aggressive behavior; Behavior; Behavior Disorders; Behavioral; Caregivers; Chronic; Clinic; Clinical; Clinical Research; Computers; Developmental Disabilities; Disease; Economics; Environment; Healthcare Systems; Home environment; Incentives; Individual; Intellectual functioning disability; Intervention; Investigation; Laboratory Research; Lead; Learning; Longevity; Parents; Persons; Plague; Positive Reinforcements; Problem behavior; Procedures; Process; Research; Research Personnel; Resources; Role; Self-Injurious Behavior; Site; Stimulus; Technology; Telecommunications; Therapeutic; Translational Research; base; cost; design; improved; innovation; novel; programs; research study; response; theories; therapy development; translational study; treatment effect

DESCRIPTION (provided by applicant): Behavior disorders, including aggression and self-injury, can cause considerable suffering for individuals with intellectual and developmental disabilities (IDD) and their care givers, as well as result in significant added costs to an already overburdened health care system. Such disorders, here termed Chronic Aberrant Behavior (CAB), have been effectively treated using procedures, provided by the field of Behavior Analysis, that are based on translational studies of operant learning principles. The purposes of this proposed program of research are to extend both the conceptual basis and range of treatment options for CAB of persons with IDD. Among the noteworthy aspects of this proposed program of research are that studies will be carried out by investigators known for the study and treatment of CAB and at three separate centers of excellence (i.e., three current IDDR Centers recognized as leaders in innovation and outstanding accomplishments for several decades). Such an approach to multi-site research has only been practical in the past few years with the dramatic advances in computer technology and telecommunications. Selection of investigators and sites can thus now be based on matching the experimental resources. Investigations conducted across the three research centers and four sites will focus on: (1) Examining the role of incentive shifts in triggering CAB and the development of interventions based on this novel conceptual framework; (2) Applying principles of behavioral economics to influence the choice of alternative constructive activities rather than CAB; and (3) Promoting generalization of therapy gains across settings, people and circumstances. An Administrative Core and Methodological Integrity Core will support the proposed research. Evidence arising from this multi-site, multi-faceted approach to the treatment of CAB in IDD will make it possible to design better therapeutic individuals with IDD to lead better lives.

描述（由申请人提供）：行为障碍，包括攻击性和自伤，可能会给智力和发育障碍 (IDD) 患者及其护理人员带来相当大的痛苦，并导致本已不堪重负的医疗保健成本大幅增加系统。这种疾病，这里称为慢性异常行为（CAB），已经使用行为分析领域提供的基于操作性学习原理的转化研究的程序得到了有效的治疗。本拟议研究计划的目的是扩展 IDD 患者 CAB 的概念基础和治疗选择范围。该拟议研究计划的一个值得注意的方面是，研究将由以研究和治疗 CAB 闻名的研究人员在三个独立的卓越中心（即当前的三个 IDDR 中心被公认为创新和杰出成就的领导者）进行。几十年）。随着计算机技术和电信的巨大进步，这种多站点研究方法直到过去几年才变得实用。因此，现在可以根据实验资源的匹配来选择研究者和地点。在三个研究中心和四个研究中心进行的调查将重点关注：（1）研究激励转变在触发 CAB 中的作用以及基于这一新颖概念框架制定干预措施； (2) 应用行为经济学原理来影响替代性建设性活动而非 CAB 的选择； (3) 促进治疗效果在不同环境、人群和环境中的普遍化。行政核心和方法完整性核心将支持拟议的研究。这种多部位、多方面治疗 IDD 中的 CAB 方法所产生的证据将使得设计更好的 IDD 治疗个体以过上更好的生活成为可能。