Predictors of Mammary Gland Development & Breast Fibroglandular Volume at puberty

乳腺发育的预测因子

基本信息

批准号：
8320454
负责人：
KARIN B MICHELS
金额：
$ 50.41万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-13 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8320454
关键词：
Accounting Address Affect Age Age at Menarche Animals Anthropometry Area Attention Birth Weight Birth length Blood Breast Breast Cancer Risk Factor C-reactive protein Cancer Susceptibility Pathway Consumption DNA Methylation Dairy Products Development Diet Dual-Energy X-Ray Absorptiometry Endocrine Disruptors Environment Event Exposure to Fatty acid glycerol esters Genes Goals Growth Growth and Development function Height Hispanics Incidence Inflammation Insulin-Like Growth Factor I Interleukin-6 International Length Lesion Life Link Malignant Neoplasms Mammary Gland Parenchyma Mammary gland Measures Meat Methylation National Institute of Environmental Health Sciences Obesity Pattern Predisposition Prospective Studies Puberty Research Risk Risk Factors Rodent Model Role Sexual Maturation Somatotropin Staging Time Variant Weight Woman bisphenol A breast cancer diagnosis breast density cancer risk cohort diaries early onset girls inflammatory marker lymphotoxin beta malignant breast neoplasm mammary gland development phthalates prepuberty programs promoter red meat consumption tumorigenesis

Accounting Address Affect Age Age at Menarche Animals Anthropometry Area Attention Birth Weight Birth length Blood Breast Breast Cancer Risk Factor C-reactive protein Cancer Susceptibility Pathway Consumption DNA Methylation Dairy Products Development Diet Dual-Energy X-Ray Absorptiometry Endocrine Disruptors Environment Event Exposure to Fatty acid glycerol esters Genes Goals Growth Growth and Development function Height Hispanics Incidence Inflammation Insulin-Like Growth Factor I Interleukin-6 International Length Lesion Life Link Malignant Neoplasms Mammary Gland Parenchyma Mammary gland Measures Meat Methylation National Institute of Environmental Health Sciences Obesity Pattern Predisposition Prospective Studies Puberty Research Risk Risk Factors Rodent Model Role Sexual Maturation Somatotropin Staging Time Variant Weight Woman bisphenol A breast cancer diagnosis breast density cancer risk cohort diaries early onset girls inflammatory marker lymphotoxin beta malignant breast neoplasm mammary gland development phthalates prepuberty programs promoter red meat consumption tumorigenesis

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项目摘要

DESCRIPTION (provided by applicant): The global burden of breast cancer is on the rise making it the malignancy with the highest incidence among women worldwide. Yet, much of the international variation of breast cancer incidence cannot be explained with known or suspected risk factors. Attention has shifted to earlier time periods of a women's life recognizing the specil susceptibility of the prepubertal mammary gland tissue to environmental influences. The considerable time lag between events prior to or at puberty and diagnosis of breast cancer spanning several decades have made prospective studies difficult to accomplish. Early onset of mammary gland development and high breast density have been associated with an increased risk of breast cancer and can serve as early putative markers of breast cancer risk. A high proportion of radiographically dense area of the breast is one of the strongest known risk factor for breast cancer and may be established at the time of breast development at puberty. We propose to use an existing cohort of about 515 prepubertal Chilean girls born in 2002 to address the relation between putative early markers of breast cancer risk, specifically onset of mammary gland development (Tanner stage 2) and volume of dense breast tissue measured by DXA at Tanner stage 4 and a number of antecedents: endocrine-disrupting chemicals, specifically bisphenol A and phthalates; frequent consumption of high fat dairy products and red meat; blood levels of inflammatory markers, specifically interleukin-6, tumor necrosis factor, and C-reactive protein; global DNA methylation, promoter methylation pattern, and methylation of the ER gene. PUBLIC HEALTH RELEVANCE: Assessing antecedents of the onset of mammary gland development and of breast density at puberty is of paramount importance for understanding determinants of breast cancer susceptibility and pathways through which early breast development and breast density affect breast cancer risk.

描述（由申请人提供）：乳腺癌的全球负担正在上升，使其成为全球女性发病率最高的恶性肿瘤。但是，无法用已知或怀疑的危险因素来解释乳腺癌发病率的许多国际变化。注意到妇女生活的较早时期，识别前乳腺组织对环境影响的特定敏感性。跨越几十年的乳腺癌之前或青春期诊断的事件之间的相当长的时间滞后使前瞻性研究难以完成。乳腺发育和高乳腺密度的早期发作与乳腺癌的风险增加有关，并可以作为乳腺癌风险的早期推定标记。乳腺的X线X射线密集面积很高是乳腺癌最强的危险因素之一，可以在青春期乳房发育时确定。 We propose to use an existing cohort of about 515 prepubertal Chilean girls born in 2002 to address the relation between putative early markers of breast cancer risk, specifically onset of mammary gland development (Tanner stage 2) and volume of dense breast tissue measured by DXA at Tanner stage 4 and a number of antecedents: endocrine-disrupting chemicals, specifically bisphenol A and phthalates;经常食用高脂乳制品和红肉；炎症标志物的血液水平，特别是白介素-6，肿瘤坏死因子和C反应蛋白； ER基因的全局DNA甲基化，启动子甲基化模式和甲基化。公共卫生相关性：评估乳腺发育发育和青春期乳腺密度发作的先例对于理解乳腺癌易感性的决定因素和早期乳房发育和乳房密度影响乳腺癌风险的途径至关重要。