TRAINING PROGRAM IN MACROMOLECULAR STRUCTURE AND MECHANISM

大分子结构与机理培训项目

• 批准号: 8291301
• 负责人: David L. Stokes
• 金额: $ 17.86万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8291301
• 关键词: Molecular Structure; Training Programs

DESCRIPTION (provided by applicant): This application seeks to establish a graduate training program in Macromolecular Structure and Mechanism at New York University School of Medicine (NYUSOM) leading to a Ph.D. degree. In this post-genomic era, detailed knowledge of macromolecules will lead to a fundamental understanding of information transfer, energy transduction and other basic mechanisms required of all biological systems. The proposed training program will combine early didactic course work, continuous mentorship from thesis committees and advisors with four years of hands-on research to prepare students for independent careers as biomedical scientists. The proposed program would represent a reconfiguration of an existing program in Structural Biology that was initiated 7 years ago with NYUSOM institutional support, namely from the Sackler Institute which oversees all graduate education at NYUSOM. To date, our existing program has graduated five students and currently contains 23 active students at various stages in their graduate studies. Four of these Students are from underrepresented minorities, reflecting the consistently high efforts by the Sackler Institute to increase the numbers and quality of minority applicants to NYUSOM. For the proposed program, we have identified 16 faculty that investigate macromolecular mechanisms using a variety of biophysical, biochemical and structural methods. These faculty can be grouped into four categories based on their research: signal transduction, membrane transport, regulation and assembly of nucleic acids, protein folding and design. These faculty have appointments in several different basic research departments at the School of Medicine and, in addition, in the Biology and Chemistry departments in the Faculty of Arts and Sciences, thus providing a highly interdisciplinary training environment. The proposed curriculum includes 1. specialized courses in the principles and methods of structural and molecular biology, 2. three research rotations, 3. formulation and defense of a research proposal, 4. continuous training and practice in research presentations, 5. discussions and lectures on ethical conduct in science and postgraduate career options, and 6. a rigorous research experience in a participating faculty member's laboratory. RELEVANCE: Detailed information about macromolecules is highly relevant to current trends in healthcare as the genome- wide sequencing gives way to investigations of the mechanisms by which biological systems function. Disease generally results from defects in or attacks on individual macromolecules; given detailed structural information, specific therapeutic agents can be designed to interfere with or ameliorate the consequences.

描述（由申请人提供）：本申请旨在在纽约大学医学院（NYUSOM）建立一项大分子结构和机制的研究生培训计划，导致博士学位。程度。在这个后期的时代，对大分子的详细知识将导致对所有生物系统所需的信息传递，能量转导和其他基本机制的基本了解。拟议的培训计划将结合早期的教学课程工作，论文委员会的持续指导以及四年的动手研究，以使学生成为生物医学科学家的独立职业。拟议的计划将代表对结构生物学现有计划的重新配置，该计划是7年前在Nyusom机构支持的情况下启动的，即来自萨克勒研究所（Sackler Institute），该研究所负责监督Nyusom的所有研究生教育。迄今为止，我们现有的课程已毕业了5名学生，目前在研究生学习的各个阶段中包含23名活跃的学生。这些学生中有四名来自代表性不足的少数群体，这反映了萨克勒学院（Sackler Institute）始终如一地提高少数民族申请人对Nyusom的数量和质量的努力。对于拟议的计划，我们已经确定了16位教职员工，这些教师使用多种生物物理，生化和结构方法研究大分子机制。这些教师可以根据其研究分为四类：信号转导，膜运输，核酸的调节和组装，蛋白质折叠和设计。这些教师在医学院的几个不同基础研究部门任命，此外，在艺术与科学学院的生物学和化学部门中，也提供了高度的跨学科培训环境。拟议的课程包括结构和分子生物学原理和方法的1个专业课程，2。三项研究轮换，3。研究建议的制定和辩护，4。研究演讲中的持续培训和实践，5。讨论和对科学生涯和研究生职业的道德行为和6。参与成员的伦理行为和演讲。相关性：有关大分子的详细信息与医疗保健的当前趋势高度相关，因为基因组广泛的测序让位于研究生物系统功能的机制。疾病通常是由于对单个大分子的缺陷或攻击而导致的；给定详细的结构信息，可以设计特定的治疗剂来干扰或改善后果。