Multi-Channel Electrochemical Measurement System

多通道电化学测量系统

基本信息

批准号：
7795013
负责人：
Martin Han
金额：
$ 15.35万
依托单位：
HUNTINGTON MEDICAL RESEARCH INSTITUTES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-25 至 2012-12-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): We are requesting funding for the purchase of a Multi-channel Electrochemical Measurement System. Neural stimulating and recording electrodes are a major component of many implantable devices. Examples include cochlear implants and central auditory prostheses which utilize electrical neural stimulations to overcome hearing loss, and deep brain stimulation to relieve the motor symptoms of Parkinson's disease. The properties of the electrodes are an important aspect of quality control both for clinical devices and in pre-clinical animal studies. Several principal investigators at Huntington Medical Research Institutes and their collaborators are conducting NIH-funded projects using implantable electrodes, in order to develop central auditory prosthesis, and advanced deep brain and spinal cord stimulators. The proposed, state-of-the-art, true multichannel measurement system allows for multiple channels of measurements to be conducted simultaneously and independently, with up to sixteen electrodes within one array or in separate arrays. The system is expected to reduce, by a factor of sixteen, the time and labor required for the electroplating of high-charge capacity electrode material, during the fabrication of recording and stimulation electrodes. When used to characterize electrodes implanted chronically into animals, the requested instrument will also reduce the duration of anesthesia by a factor of sixteen, and may sufficiently expedite these procedures such that in some instances anesthesia will not be required. This will reduce the risk of death or medical complication for these valuable animals.

描述（由申请人提供）：我们正在请求资助购买多通道电化学测量系统。神经刺激和记录电极是许多植入式设备的主要组成部分。例子包括人工耳蜗和中枢听觉假体，它们利用电神经刺激来克服听力损失，以及利用深部脑刺激来缓解帕金森病的运动症状。电极的特性是临床设备和临床前动物研究质量控制的一个重要方面。亨廷顿医学研究所的几位主要研究人员及其合作者正在使用植入式电极开展美国国立卫生研究院资助的项目，以开发中枢听觉假体以及先进的深部大脑和脊髓刺激器。所提出的最先进的真正多通道测量系统允许同时独立地进行多个通道的测量，在一个阵列或单独的阵列中最多有十六个电极。该系统预计可将记录电极和刺激电极制造过程中电镀高电荷容量电极材料所需的时间和劳动力减少十六倍。当用于表征长期植入动物体内的电极时，所需的仪器还将麻醉持续时间缩短十六倍，并且可以充分加快这些过程，以便在某些情况下不需要麻醉。这将降低这些珍贵动物的死亡或医疗并发症的风险。