Investigative Training in Hepatology

肝病学调查培训

• 批准号: 8301012
• 负责人: MICHAEL H NATHANSON
• 金额: $ 25.89万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8301012
• 关键词: Hepatology; Training

DESCRIPTION (provided by applicant): The goal of this training program is to provide basic laboratory, translational, or clinical research training for physicians who have completed clinical training in gastroenterology in preparation for careers as independent investigators in academic hepatology and to provide research training for recent Ph.D. graduates to prepare them for careers as independent investigators in basic liver-related research. Physicians will be supported for three years and Ph.D. trainees for two years. Selection of trainees will be based on strong prior research experience and commitment to liver-related research. This training program will use the combined resources of the Yale Section of Digestive Diseases, the NIH funded Yale Liver Center and facilities of the participating faculty including the Departments of Internal Medicine, Cell Biology, Cellular and Molecular Physiology, Human Genetics, Laboratory Medicine, Pediatrics, and Pharmacology. The major research areas represented include 1) cellular, molecular, developmental, and stem cell biology of the liver, 2) signal transduction mechanisms in the liver, 3) hepatic metabolism, 4) regulation and control of the splanchnic circulation, 5) infection, inflammation, immunity, and fibrosis in the liver and 6) genetic approaches to liver disease. A strong educational curriculum is provided by the Section of Digestive Diseases and the Medical School's Investigative Medicine Program as well as enrichment programs provided by the Liver Center. Trainees are encouraged to audit or enroll in specific courses in the School of Medicine or the School of Public Health, attend an annual laboratory and lecture course designed for physician trainees in the Department of Medicine, and are required to attend both the Hepatology and Basic Science Journal Clubs, and twice weekly research and path physiology seminars. Progress is monitored through several mechanisms including "Research in Progress" seminars and individual Progress Committees. PUBLIC HEALTH RELEVANCE: Liver disease is a leading cause of morbidity and mortality among Americans. There is a need to better understand the causes of liver diseases and develop improved treatments. This grant seeks funds to train physicians and scientists to investigate the causes of liver disease and to develop improved treatments.

描述（由申请人提供）： 该培训计划的目标是为已完成胃肠病学临床培训的医生提供基本的实验室、转化或临床研究培训，为学术肝病学独立研究者的职业生涯做好准备，并为最近的博士学位提供研究培训。毕业生为他们成为基础肝脏相关研究的独立调查员做好准备。医生将获得三年的支持，博士学位也将获得支持。实习生为期两年。学员的选择将基于丰富的先前研究经验和对肝脏相关研究的承诺。该培训计划将利用耶鲁大学消化疾病科、美国国立卫生研究院资助的耶鲁肝脏中心和参与教师的设施（包括内科、细胞生物学、细胞和分子生理学、人类遗传学、检验医学、儿科）的综合资源和药理学。主要研究领域包括 1) 肝脏的细胞、分子、发育和干细胞生物学，2) 肝脏的信号转导机制，3) 肝脏代谢，4) 内脏循环的调节和控制，5) 感染，肝脏的炎症、免疫和纤维化，以及 6) 肝脏疾病的遗传方法。消化疾病科和医学院的研究医学项目以及肝脏中心提供的强化项目提供了强大的教育课程。鼓励学员旁听或报名参加医学院或公共卫生学院的特定课程，参加为医学系实习医生设计的年度实验室和讲座课程，并要求参加肝病学和基础科学课程期刊俱乐部以及每周两次的研究和路径生理学研讨会。通过多种机制监测进展情况，包括“正在进行的研究”研讨会和单独的进展委员会。 公共卫生相关性：肝病是美国人发病和死亡的主要原因。需要更好地了解肝脏疾病的原因并开发改进的治疗方法。这笔赠款寻求资金来培训医生和科学家调查肝病的原因并开发改进的治疗方法。