Training Program in Investigative Gastroenterology and Hepatology

胃肠病学和肝病学研究培训计划

• 批准号: 10628499
• 负责人: SCOTT L. FRIEDMAN
• 金额: $ 26.83万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628499
• 关键词: Gastroenterology; Hepatology; Training Programs

The burden of digestive diseases in the United States is staggering, with annual costs exceeding $140 billion, based on National Institutes of Health (NIH) estimates. To meet this challenge, a key mission of the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) is to support the training of a talented, diverse pool of young investigators who will attack scientific unmet needs to improve the lives of patients with gastrointestinal and liver diseases. The Icahn School of Medicine at Mount Sinai (ISMMS) has been a center of excellence for care in gastrointestinal and liver diseases for decades, with clinical fellowship programs in these disciplines consistently ranked among the best in the country. Moreover, ISMMS offers a fertile environment from which a cadre of outstanding candidates have launched successful careers in academic gastroenterology and hepatology. The overarching goal of this Training Program proposal is to leverage this outstanding environment to support the training of M.D., M.D./Ph.D or Ph.D. postdoctoral fellows by providing exceptional research opportunities and mentorship in three broad areas: A) Gastrointestinal inflammation and the microbiome; B) Non-alcoholic steatohepatitis (NASH), hepatic inflammation and fibrosis; and C) Genetics of gastrointestinal and liver diseases. The highly structured training program provides a tailored curriculum that integrates clinico-epidemiologic-, genetic-, environmental- and cellular/molecular research excellence. The program is built upon a foundation of world class research faculty who have outstanding track records of academic achievement and successful mentorship. The curriculum focuses on cross-disciplinary training in order to prepare trainees for the current and future challenges of gastrointestinal and liver disease research, which now requires integration of complementary research skill sets. To address this need, a highly selected pool of mentors has been chosen not only from within the Divisions of GI and Liver Diseases and other clinical disciplines, but who also represent outstanding multi-disciplinary institutes at the ISMMS. Each year this program will support 3 trainees (PGY 4 - PGY 6), with 15 candidates entering the program over 5 years. Each trainee will pursue an individualized research project and tailored curriculum formulated together with their primary and secondary mentors, curriculum committee and the Program Directors. Trainees will dedicate at least 90% effort in either the laboratory or clinical setting, and their progress will be monitored through quarterly meetings with their advisory committee and program directors. Overall quality and adaptability of the program will be ensured through oversight by internal and external advisory boards, based on compliance with defined metrics of success for both individual trainees and the overall program. This rigorously structured and closely monitored program, committed to excellence and built upon a rich scientific environment and outstanding faculty, will yield superbly trained future leaders in investigative gastroenterology and hepatology.

美国消化疾病的负担令人震惊，每年成本超过1400亿美元， 根据国立卫生研究院（NIH）的估计。为了应对这一挑战，国家的关键使命 糖尿病，消化系统和肾脏疾病（NIDDK）的研究所是为了培训才华横溢的多样化 一群将攻击科学未满足的年轻调查员，以改善患者的生活 胃肠道和肝病。 西奈山（ISMMS）的伊坎医学院一直是胃肠道的卓越护理中心 数十年来，这些学科中的临床奖学金计划始终排名 该国最好的。此外，ISMM提供了一个肥沃的环境 候选人在学术胃肠病和肝病学方面启动了成功的职业。总体 该培训计划建议的目标是利用这个杰出的环境来支持训练 M.D.，M.D./PH.D或Ph.D。博士后研究员通过提供卓越的研究机会和指导 在三个广泛的区域：a）胃肠道炎症和微生物组； b）非酒精性脂肪性肝炎 （NASH），肝炎和纤维化； c）胃肠道和肝病的遗传学。高度 结构化培训计划提供了一个量身定制的课程，该课程整合了临床流行病学，遗传学 - 环境和细胞/分子研究卓越。该计划建立在世界一流的基础之上 具有出色的学术成就和成功指导的杰出记录的研究学院。这 课程专注于跨学科培训，以便为受训者准备当前和未来的挑战 胃肠道和肝病研究，现在需要整合补充研究技能 套。为了满足这一需求，不仅从部门中选择了高度选择的导师库 胃肠道和肝病和其他临床学科，但他们也代表了杰出的多学科 ISMM的机构。 该计划每年都会支持3名受训者（PGY 4- PGY 6），有15名候选人进入该计划 5年。每个学员将追求一个个性化的研究项目，并量身定制的课程 与他们的主要和次要导师，课程委员会和计划主管。学员会 在实验室或临床环境中奉献至少90％的努力，将通过 与他们的咨询委员会和计划主管的季度会议。总体质量和适应性 基于遵守的内部和外部咨询委员会将通过监督来确保计划 单个学员和整体计划的成功指标定义。这种严格的结构化和 密切监控的计划，致力于卓越，并建立在丰富的科学环境和杰出的基础上 教师将产生训练有素的胃肠病学和肝病学领导者。