Reduce Risk of Diabetes:Healthy Lifestyle for Chinese Immigrants

降低糖尿病风险：中国移民的健康生活方式

基本信息

批准号：
8239547
负责人：
JUDITH WYLIE-ROSETT
金额：
$ 21.23万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8239547
关键词：
Acculturation Adoption Affect Applications Grants Asians Biological Markers Blood Glucose Blood Pressure Body Weight Body Weight Changes Body Weight decreased Body fat Body mass index Cardiovascular Diseases Child China Chinese American Chinese People Clinical Trials Communities Counseling Diabetes Mellitus Diabetes prevention Dietary Practices Dietary intake Effectiveness Enrollment Evaluation Fasting Fatty acid glycerol esters Food Frequencies Future Generations Glycosylated hemoglobin A Goals Health High Density Lipoprotein Cholesterol Hip region structure Immigrant Incidence Individual Insulin Insulin Resistance Intake Intervention LDL Cholesterol Lipoproteins Life Style Lipids Long-Term Effects Maintenance Measures Mental Depression Non-Insulin-Dependent Diabetes Mellitus Outcome Outcome Measure Overweight Participant Patients Pattern Pharmaceutical Preparations Physical activity Pilot Projects Population Population Group Protocols documentation Questionnaires Randomized Clinical Trials Relative (related person)Reporting Risk Stress Testing Translating Triglycerides Underserved Population United States Weight arm base cardiovascular risk factor diabetes prevention program diabetes risk diabetic eligible participant fasting glucose follow-up high risk intervention effect lifestyle intervention programs psychologic randomized trial secondary outcome text searching

项目摘要

DESCRIPTION (provided by applicant): The goal of this R34 application is to create and formative evaluate an intervention that promotes healthful lifestyle for Chinese immigrants at risk for developing diabetes based on the principles of Diabetes Prevention Program intervention. The acceptability and feasibility of the intervention will be assessed in a two-arm pilot randomized trial (n=60) that will compare the effects of a lifestyle intervention (n=30) to a minimal control intervention (n=30). The R34 evaluation at the end of 6 months and at 12 months will examine changes in weight and biomarkers including fasting blood glucose and insulin, HbA1c, lipid profile (total, HDL and LDL cholesterol, and triglycerides), and blood pressure. Measures of lifestyle changes will include dietary intake and physical activity. The study will also assess change in psychological measures. The pilot study will use the RE-AIM evaluation framework to focus on: Reach - How many of the eligible participants actually enrolled in the study? Efficacy/Effectiveness -How did the intervention affect participant's weight and other measures? Adoption: How acceptable were the interventions to the participants? Implementation - How many of the intervention activities were provided as planned? Maintenance - How much of the intervention effect is sustainable? The longer term effects of the intervention will be evaluated in a subsequent R18 clinical trial. PUBLIC HEALTH RELEVANCE: Lifestyle change can reduce the risk of developing diabetes. This project will tailor the successful Diabetes Prevention Program lifestyle intervention to focus on the needs of high risk immigrants from China. The effects of the intervention will be evaluated in a pilot study assessing lifestyle and weight changes. The evaluation of the intervention will be used to plan a larger study to examine health outcomes.

描述（由申请人提供）：本 R34 申请的目标是根据糖尿病预防计划干预的原则，创建并形成性评估一项干预措施，以促进有糖尿病风险的中国移民的健康生活方式。干预措施的可接受性和可行性将在一项双组试点随机试验 (n=60) 中进行评估，该试验将比较生活方式干预 (n=30) 与最低限度控制干预 (n=30) 的效果。 6 个月末和 12 个月时的 R34 评估将检查体重和生物标志物的变化，包括空腹血糖和胰岛素、HbA1c、血脂（总胆固醇、HDL 和 LDL 胆固醇以及甘油三酯）和血压。生活方式改变的衡量标准包括饮食摄入和身体活动。该研究还将评估心理指标的变化。该试点研究将使用 RE-AIM 评估框架重点关注：覆盖范围 - 有多少符合条件的参与者实际参加了该研究？功效/效果 - 干预措施如何影响参与者的体重和其他指标？采用：参与者对干预措施的接受程度如何？实施 - 有多少干预活动按计划进行？维持——干预效果有多少是可持续的？干预措施的长期效果将在随后的 R18 临床试验中进行评估。公共卫生相关性：生活方式的改变可以降低患糖尿病的风险。该项目将量身定制成功的糖尿病预防计划生活方式干预措施，重点关注来自中国的高风险移民的需求。干预措施的效果将在一项评估生活方式和体重变化的试点研究中进行评估。对干预措施的评估将用于计划一项更大规模的研究来检查健康结果。