Vastly Accelerated Dynamic Spiral MR Liver Imaging

大幅加速动态螺旋 MR 肝脏成像

• 批准号: 8323863
• 负责人: Pascal Spincemaille
• 金额: $ 21.13万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8323863
• 关键词: Acute; Biopsy; Calibration; Chronic; Cirrhosis; Concentration measurement; Contrast Media; Detection; Development; Diagnosis; Disease; Disease Progression; Early Diagnosis; Evaluation; Fibrosis; Goals; Gold; Hepatic; Image; Interobserver Variability; Intervention; Intraobserver Variability; Kinetics; Lead; Liver; Liver Cirrhosis; Liver Fibrosis; Liver diseases; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modeling; Monitor; Morphologic artifacts; Outcomes Research; Patients; Perfusion; Phase; Predisposition; Procedures; Public Health; Reliance; Reproducibility; Research; Resolution; Risk; Sampling; Sampling Errors; Signal Transduction; Staging; System; Techniques; Testing; Time; Tracer; Treatment Efficacy; base; chronic liver disease; data acquisition; imaging modality; improved; liver biopsy; liver function; liver imaging; uptake

DESCRIPTION (provided by applicant): Liver fibrosis and its most advanced stage, cirrhosis, are consequences of chronic and acute hepatic disease. Fibrosis leads to a loss of liver function and both regional and global perfusion changes. Currently, the gold standard for assessing fibrosis is liver biopsy, which is an invasive technique. The long-term goal is to develop a robust and accurate non-invasive method for detecting and staging liver fibrosis and cirrhosis. The objective of this research, as part of that goal, is to develop a dynamic contrast enhanced magnetic resonance imaging (DCE MRI) that is highly reproducible. Our hypothesis is that a high reproducibility of DCE-MRI perfusion parameter measurement can be achieved using by using a continuous MR data acquisition and a contrast concentration measurement based on susceptibility. The rationale for the proposed research is that the proposed perfusion method will enable the quantification of subtle and early changes in liver function induced by fibrosis to allow for intervention prior to progression to cirrhosis or malignancies at a later stage. To test the hypothesis, the following two specific aims are pursued: 1) the development a MR perfusion imaging method using a continuous high frame rate image acquisition and susceptibility based concentration measurement and 2) the evaluation of its test-retest reproducibility in a group of healthy subjects as well as a group of patients with biopsy proven cirrhoses. It is expected that this method will ultimately lead to the ability to distinguish intermediate from advanced stages of liver fibrosis. This is likely to have a positive impact, because it would provide the ability to monitor disease progression and treatment efficacy for chronic liver disease.

描述（由申请人提供）：肝纤维化及其最晚期的肝硬化是慢性和急性肝病的后果。纤维化导致肝功能丧失以及局部和整体灌注变化。目前，评估纤维化的金标准是肝活检，这是一种侵入性技术。长期目标是开发一种稳健且准确的非侵入性方法来检测肝纤维化和肝硬化并对其进行分期。作为该目标的一部分，本研究的目的是开发一种高度可重复的动态对比增强磁共振成像 (DCE MRI)。我们的假设是，通过使用连续 MR 数据采集和基于磁敏度的造影剂浓度测量，可以实现 DCE-MRI 灌注参数测量的高重复性。这项研究的基本原理是，所提出的灌注方法将能够量化纤维化引起的肝功能的微妙和早期变化，以便在后期进展为肝硬化或恶性肿瘤之前进行干预。为了检验这一假设，我们追求以下两个具体目标：1) 开发一种使用连续高帧率图像采集和基于磁敏度的浓度测量的 MR 灌注成像方法，2) 评估其在一组受试者中的重测再现性。健康受试者以及一组活检证实患有肝硬化的患者。预计该方法最终将能够区分肝纤维化的中期和晚期阶段。这可能会产生积极影响，因为它将提供监测慢性肝病疾病进展和治疗效果的能力。