Novel Dynamic Liver Imaging Method with Flexible Temporal and Spatial Resolution

具有灵活时间和空间分辨率的新型动态肝脏成像方法

• 批准号: 8247701
• 负责人: Pascal Spincemaille
• 金额: $ 18.38万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8247701
• 关键词: Affect; Bolus Infusion; Breathing; Carcinoma; Characteristics; Computer software; Contrast Media; Data; Data Set; Detection; Development; Diagnosis; Diagnostic; Disease; Four-dimensional; Gadolinium; Goals; Hepatic; Hybrids; Image; Imagery; Imaging technology; Injection of therapeutic agent; Ionizing radiation; Lead; Lesion; Liver; Liver Cirrhosis; Liver diseases; Liver parenchyma; Living Donor Liver Transplantation; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of liver; Methods; Motion; Outcomes Research; Patients; Pattern; Performance; Perfusion; Phase; Primary carcinoma of the liver cells; Process; Public Health; Radial; Reader; Reliance; Research; Resolution; Risk; Sampling; Sampling Errors; Scanning; Sensitivity and Specificity; Signal Transduction; Staging; Techniques; Technology; Testing; Time; Transplantation; Vascular blood supply; Venous; Waiting Lists; Work; X-Ray Computed Tomography; base; compliance behavior; diagnostic accuracy; flexibility; follow-up; gadolinium oxide; image reconstruction; image visualization; imaging modality; improved; interest; interstitial; liver biopsy; liver imaging; liver transplantation; navigation aid; novel; public health relevance; respiratory; skills; spatiotemporal; tool; treatment planning; uptake

DESCRIPTION (provided by applicant): Liver cancer presents an increasing burden on public health. Currently, a 3D multi-phase contrast-enhanced MR exam is used to separate the arterial from the venous blood supply to any lesion to determine whether it is malignant or not. It relies heavily on the ability of the patient to sustain a breath-hold, but in a considerable subset of patients, this ability is compromised, leading to a sharp decrease in image quality. It also relies on accurate bolus timing by the operator, such that the first so-called hepatic arterial phase is acquired at the right peak arterial enhancement. Bolus timing errors lead to a suboptimal view of the enhancement pattern, negatively affecting the ability to accurately diagnose liver disease. The long-term goal of this research is to improve the robustness and accuracy of MR imaging of the liver for the detection of hepatocellular carcinoma and other malignancies. The objective of this research, as part of that goal, is to develop a robust image acquisition and visualization technology. The hypothesis in this research is that this technology eliminates these requirements and optimally presents all available dynamic information to the reader. The rationale for the proposed research is that a robust and accurate dynamic imaging method enables the fast extraction of all necessary contrast uptake and washout information for the accurate diagnosis of liver lesions. To test the hypothesis, the following two specific aims are pursued: 1) develop a three-dimensional time-resolved contrast-enhanced free-breathing imaging sequence with high temporal and spatial resolution together with an interactive four-dimensional visualization and post-processing engine, and 2) evaluate the diagnostic performance of the developed free-breathing liver MRI sequence in a patient study. The expected outcome of this research is an interactive dynamic MR imaging method of the liver that will significantly improve the way liver lesions are detected and characterized. Such a technique is likely to have a positive impact, since it expected to increase the sensitivity and specificity of liver MRI and to reduce the need for liver biopsy and the reliance on patient cooperation and operator skill. . PUBLIC HEALTH RELEVANCE: The proposed research is relevant to public health because, if completed successfully, it is expected to increase the sensitivity and specificity of liver MRI. It will reduce the need for liver biopsy and the reliance on patient cooperation and operator skill. It is likely to lead to significant improvements in the staging of hepatocellular carcinomas and in the assignment of ranking scores for liver transplantation.

描述（由申请人提供）：肝癌给公共卫生带来了增加的负担。当前，使用3D多相对比增强的MR检查用于将动脉与静脉血液供应分开为任何病变，以确定其是否是恶性肿瘤。它严重依赖患者维持呼吸呼吸的能力，但是在大量患者中，这种能力受到损害，从而导致图像质量急剧下降。它还依赖于操作员的准确推注时机，以便在右峰动脉增强处获得了第一个所谓的肝动脉相。推注时误差导致增强模式的次优视力，对准确诊断肝病的能力产生负面影响。这项研究的长期目标是提高肝脏癌和其他恶性肿瘤检测肝脏MR成像的鲁棒性和准确性。作为该目标的一部分，这项研究的目的是开发强大的图像获取和可视化技术。这项研究的假设是，该技术消除了这些要求，并最佳地向读者提供了所有可用的动态信息。拟议的研究的基本原理是，一种可靠，准确的动态成像方法可以快速提取所有必要的对比度摄取和冲洗信息，以准确诊断出肝脏病变。 To test the hypothesis, the following two specific aims are pursued: 1) develop a three-dimensional time-resolved contrast-enhanced free-breathing imaging sequence with high temporal and spatial resolution together with an interactive four-dimensional visualization and post-processing engine, and 2) evaluate the diagnostic performance of the developed free-breathing liver MRI sequence in a patient study.这项研究的预期结果是一种肝脏的交互式动态MR成像方法，可显着改善检测和表征肝病的方式。这样的技术可能会产生积极的影响，因为它预计会提高肝脏MRI的敏感性和特异性，并减少对肝活检的需求以及对患者合作和操作员技能的依赖。 。 公共卫生相关性：拟议的研究与公共卫生有关，因为如果成功完成，预计将提高肝脏MRI的敏感性和特异性。它将减少对肝活检的需求，并依赖患者合作和操作员技能。它可能会导致肝细胞癌的分期以及肝移植的排名得分分配。