Innate intelligence and prognostication for prevention of neurodegeneration

预防神经退行性变的先天智力和预测

基本信息

批准号：
8552366
负责人：
Stuart Maudsley
金额：
$ 24.39万
依托单位：
NATIONAL INSTITUTE ON AGING
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

项目摘要

Summary Cognitive impairment places a severe burden upon both the sufferers and their carers. While approximately 5-10% of patients displaying cognitive impairment possess a genetic predisposition, such as a Flemish or Swedish mutation in the amyloid pre-cursor protein, the majority of patients do not possess such an obvious cause of their malady. The causes of age-dependent cognitive decline in the general population are likely to extremely diverse and therefore multifactorial. However there is one phenomenon that is generally expressed in the population, cognitive performance in tasks, that appears to be positively correlated to a prophylactic action against age-dependent neurodegeneration. This underlies the anecdotal adage of the use it or lose it phenomenon. Hence in this study we are attempting to understand not only the natural basis for cognitive capacity but also hopefully elucidate signaling mechanisms that are linked to this capacity that possess an intrinsic neuroprotective action. We are already nearing the completion of the first phase of this study in which we have used a large genetically identical murine pool of both male and female animals. We are in the process of generating a semi-quantitative relationship between protein expression in the cortex and hippocampus of these animals and their maze solving capacity. We feel that the data derived from this study will illuminate the field of cognition and provide a novel insight into the molecular basis of individual intellectual variation.

概括认知障碍给患者及其护理人员带来了巨大负担。尽管大约5-10％的表现出认知障碍的患者具有遗传易感性，例如淀粉样蛋白蛋白质蛋白质中的佛兰德或瑞典突变，但大多数患者没有明显的原因导致其疾病。普通人群依赖年龄依赖性认知能力下降的原因可能非常多样化，因此多因素。但是，在人群中通常表达了一种现象，即任务中的认知表现，这似乎与针对年龄依赖性神经变性的预防作用呈正相关。这是用法的轶事格言或失去现象的轶事。因此，在这项研究中，我们不仅试图了解认知能力的自然基础，而且希望阐明与具有内在神经保护作用的能力相关的信号传导机制。我们已经接近了这项研究的第一阶段的完成，在该研究中，我们使用了大量的雄性和雌性动物的遗传鼠库。我们正在这些动物的皮质和海马中的蛋白质表达与它们的迷宫求解能力之间产生半定量关系。我们认为，从这项研究中得出的数据将阐明认知领域，并为个人智力变异的分子基础提供新的见解。