Aging Research at the 2010 through 2014 ASHEcon Biennial Conferences

2010 年至 2014 年 ASHEcon 双年度会议上的老龄化研究

基本信息

批准号：
8291259
负责人：
Jody L. Sindelar
金额：
$ 2.5万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8291259
关键词：
Achievement Affect Age Aging Aging-Related Process Alzheimer&apos s Disease American Amino Acids Area Attention Basic Science Biochemistry Biogenesis Biomedical Research Cell physiology Cells Commit Communicable Diseases Community Health Development Diabetes Mellitus Diffusion Discipline Disease Economics Educational process of instructing Elderly Ensure Environment Equilibrium Evolution Explosion Failure Fertilization Financial Support Funding Future Gender Generations Goals Growth Health Health Care Reform Health Insurance Health Policy Health behavior Hearing Heart Diseases Heat shock proteins Homeostasis Hospitals Humanities International Laboratories Life Long-Term Care Malignant Neoplasms Mediating Medicare Metabolic Diseases Methods Molecular Chaperones Neurodegenerative Disorders Oral Organism Outcome Paper Parkinson Disease Pathway interactions Physicians Policies Polymers Preventive Process Professional Organizations Proteins Proteolysis Quality Control Quality of Care Regulation Research Research Personnel Retirement Role Scientist Services Signal Transduction Pathway Societies Stress System Technology Time Training Translating Treatment outcome Underrepresented Minority Universities Wisconsin abstracting age related base biological adaptation to stress blind comparative effectiveness cost experience health economics high standard in vivo innovation interest lectures meetings next generation normal aging payment polyglutamine polypeptide posters protein folding protein function protein misfolding protein transport racial and ethnic response success symposium web site

项目摘要

ABSTRACT This proposal is a request for partial financial support for a meeting on Molecular Chaperones and Stress Responses to be held from May 4 - 8, 2010 at Cold Spring Harbor Laboratory. This meeting is the premier international format for presentation of new results in this area, and is attended by representatives from virtually every major laboratory in the field. The explosion of new information on how the folded state of proteins is acquired and maintained in vivo and the involvement of this process in an increasing number of disease states and in normal aging guarantees the excitement of this meeting. Among the highlights of the meeting will be sessions devoted to: (1) Protein misfolding and disease, emphasizing the role of alternative folding pathways in protein biogenesis and lifecycle and mounting evidence for chaperone involvement in Alzheimer's Disease, polyglutamine diseases and the aging process (2) new structural and mechanistic information on some intensively studied chaperones, (3) the role of chaperones in diverse cellular transactions and the signal transduction pathways that integrate them, (4) the crosstalk between protein folding and proteolysis mediated by chaperones, (5) how the various protein folding and quality control systems in a cell function together to provide a robust protein folding environment and how the breakdown of such protein homeostasis (proteostasis) contributes to disease and normal aging, (6) the diverse protein quality control strategies used by a cell to ensure the integrity of the secretory pathway during times of protein folding stress. The field of heat shock proteins and molecular chaperones has grown rapidly and draws interest not only from traditional scientific disciplines in the basic sciences but also from numerous areas of biomedical research including neurodegenerative disease, infectious diseases, cancer, heart disease and aging. The meeting will include seven lecture and three poster sessions. The proposed sessions include: I- Chaperone Biochemistry & Protein Folding, II- Chaperone Function in Disease and Development, III- Diseases of Protein Misfolding IV- Quality Control & Protein Trafficking V- Evolution and Regulation of Protein Folding Machines, VI- Chaperones and Proteolysis, and VII- Manipulating Chaperone Networks and Protein Folding Pathways. Each session will consist of eight to nine oral presentations and will be chaired by an invited speaker. A maximum of two additional speakers will be pre-invited per session and the remainder will be selected from submitted abstracts. This balance of talks allows the meeting to feature presentations by leading scientists, to be responsive to exciting new developments, to encourage diverse participation and to recognize new investigators. The subsequent meetings (2012 and 2014) will follow a similar format and will include topics highly relevant to the current research at the time of the meeting.

抽象的该提案是为了在2010年5月4日至8日在冷泉港实验室举行的有关分子伴侣的会议和压力反应的要求。这次会议是在该领域提出新结果的首要国际格式，几乎来自该领域的每个主要实验室的代表参加。关于如何在体内获取和维持蛋白质折叠状态的新信息的爆炸以及该过程参与越来越多的疾病状态，并且在正常衰老中保证了这次会议的兴奋。 Among the highlights of the meeting will be sessions devoted to: (1) Protein misfolding and disease, emphasizing the role of alternative folding pathways in protein biogenesis and lifecycle and mounting evidence for chaperone involvement in Alzheimer's Disease, polyglutamine diseases and the aging process (2) new structural and mechanistic information on some intensively studied chaperones, (3) the role of chaperones （4）蛋白质折叠和由伴侣介导的蛋白水解之间的串扰在多种细胞交易和信号转导途径中一个细胞，以确保在蛋白质折叠应力时期分泌途径的完整性。热休克蛋白和分子伴侣的领域迅速发展，不仅从基本科学中的传统科学学科中引起了人们的兴趣，而且还来自许多生物医学研究领域，包括神经退行性疾病，感染性疾病，癌症，心脏病，心脏病和衰老。会议将包括七个讲座和三个海报会议。提出的会话包括：I-伴侣生物化学和蛋白质折叠，II-伴侣在疾病和发育中的功能，蛋白质疾病的疾病，蛋白质疾病疾病 - 折叠式IV-质量控制和蛋白质运输V-蛋白质折叠机的进化以及蛋白质折叠机的调节，Vi-Chaperone，Vi-Chaperone，Vi-Chaperone，vi-chaperone and Proteeyssiss and Prote-I-I-I-II-Manipuling Chaperulate Chaperane网络和蛋白质折叠率。每个会议将由八到九个口头演讲组成，并由受邀发言人主持。每个会话最多将预先启动两个扬声器，其余的将从提交的摘要中选择。谈话平衡使会议能够通过领先的科学家进行演讲，对令人兴奋的新发展做出反应，以鼓励各种各样的参与并认可新的调查人员。随后的会议（2012年和2014年）将遵循类似的格式，并将包括与当前的会议时研究高度相关的主题。