Hypertension in Pregnancy and Future Cardiovascular Disease

妊娠期高血压和未来的心血管疾病

基本信息

批准号：
8367407
负责人：
VIRGINIA M MILLER
金额：
$ 26.22万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8367407
关键词：
Address Affect Age Biological Blood Platelets Blood Vessels Brain Cardiovascular Diseases Cardiovascular system Caring Case-Control Studies Chronic Clinical Cognition Cognitive Cohort Studies County Data Dementia Diagnosis Diagnostic Disease Disease Outcome Educational workshop Epidemiologic Studies Epidemiology Female Frequencies Functional disorder Future Guidelines Health Heart Diseases Heart failure Hormones Hypertension Hypertension induced by pregnancy Impaired cognition Incidence Life Menopause Morbidity - disease rate Mothers National Heart, Lung, and Blood Institute Outcome Pathogenesis Patient Self-Report Patients Postpartum Period Pre-Eclampsia Pregnancy Prevention Proteinuria Publishing Recording of previous events Records Recruitment Activity Reporting Research Residual state Risk Risk Factors Sampling Series Sex Characteristics Stroke Subgroup System Testing Time Treatment Efficacy Variant Woman base cardiovascular risk factor cerebrovascular cognitive function fetal male men modifiable risk mortality neuroimaging normotensive outcome forecast population based pregnancy disorder sex treatment strategy

项目摘要

Cardiovascular epidemiologic research historically has focused on men, because male sex is one of the major risk factors for CVD. Consequently, numerous diagnostic and treatment strategies for CVD in women have been extrapolated from results of studies conducted in men, and sex-specific factors largely have been ignored. It became apparent in the 1980s that the decrease in cardiovascular mortality in men was not accompanied by a similar decrease in women. One of the reasons for this difference might be sex-based disparities in cardiovascular care; women have been both under evaluated for CVD and under treated for modifiable risk factors for CVD. In addition, female-specific conditions, such as hypertensive disorders of pregnancy, menopause, and hormone use, might affect the onset of CVD, its clinical course, the efficacy of therapy, and, ultimately, prognosis. This proposal responds to RFA-OD-11-003 by identifying complications of hypertensive pregnancy disorders as a major biological sex difference that may influence the future cardiovascular and cognitive health of the affected women. Results of the proposed research may open new venues for the prevention, diagnosis, and treatment of CVD and cognitive impairment in women.

从历史上看，心血管流行病学研究一直集中在男性上，因为男性是主要的男性 CVD的风险因素。因此，女性CVD的许多诊断和治疗策略从男性进行的研究结果中推断出来，并且在很大程度上被忽略了性别特异性因素。在1980年代显然，男性心血管死亡率的降低没有伴随女性类似下降。这种差异的原因之一可能是基于性别的差异在心血管护理中；妇女都对CVD进行了评估，并且对可修改的治疗不足 CVD的风险因素。此外，女性特异性疾病，例如怀孕的高血压疾病，更年期和激素的使用可能会影响CVD的开始，其临床过程，治疗的功效以及，最终，预后。该提案通过确定高血压妊娠疾病并发症来应对RFA-OD-11-003 作为可能影响未来心血管和认知健康的主要生物学差异受影响的妇女。拟议研究的结果可能为预防，诊断和治疗女性CVD和认知障碍。